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DISTINGUISHING RECRUDESCENCE FROM REINFECTION IN A LONGITUDINAL ANTIMALARIAL DRUG EFFICACY STUDY: COMPARISON OF RESULTS BASED ON GENOTYPING OF MSP-1, MSP-2, AND GLURP
Abstract
Genotyping frequently is used to distinguish recrudescent from new infections in antimalarial drug efficacy trials, but methodology and interpretation of results have not been standardized. We compared the utility of polymorphisms within 3 Plasmodium falciparum genes during a longitudinal trial in Kampala, Uganda. Merozoite surface protein-1 (msp-1) and merozoite surface protein-2 (msp-2) revealed greater diversity than glutamate-rich protein. Genotypes based on msp-1, msp-2, and all 3 genes combined were compared for 394 initial and subsequent isolates. Classification of most episodes as due to recrudescence or reinfection was straightforward. In 24% (msp-1), 16% (msp-2), and 62% (3 genes combined) of samples, subsequent episodes contained identical and new alleles, however. Our analysis suggested that such episodes should be classified as reinfections and not recrudescence. Comparing the 3 studied genes, msp-2 results were most accurate, and analysis of this single gene effectively distinguished recrudescence from reinfection in our study population.
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Cited by
Relapses of Plasmodium vivax Infection Usually Result from Activation of Heterologous Hypnozoites
Imwong, M., Snounou, G., Pukrittayakamee, S., Tanomsing, N., Kim, J. R., Nandy, A., Guthmann, J., Nosten, F., Carlton, J., Looareesuwan, S., et al. (2007) · The Journal of Infectious Diseases · doi:10.1086/512241 · Cited by 294
Ghanchi, N. K., Mårtensson, A., Ursing, J., Jafri, S., Bereczky, S., Hussain, R., & Beg, M. A. (2010) · Malaria Journal · doi:10.1186/1475-2875-9-1 · Cited by 162
Kyabayinze, D. J., Tibenderana, J. K., Nassali, M., Tumwine, L. K., Riches, C., Montague, M., Counihan, H., Hamade, P., Van Geertruyden, J.-P., & Meek, S. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-306 · Cited by 42
Self-citationRatsimbasoa, A., Ravony, H., Vonimpaisomihanta, J.-A., Raherinjafy, R., Jahevitra, M., Rapelanoro, R., Rakotomanga, J. D. D. M., Malvy, D., Millet, P., & Ménard, D. (2012) · The American Society of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2012.11-0047 · Cited by 22
Metadata
- Authors
- CATTAMANCHI, A., KYABAYINZE, D., HUBBARD, A., ROSENTHAL, P. J., & DORSEY, G.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2003-02
- Volume
- 68
- Issue
- 2
- Pages
- 133-139
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2163924699
- Cited by
- 166
- References
- 0
- FWCI
- 16.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- CATTAMANCHI, A., KYABAYINZE, D., HUBBARD, A., ROSENTHAL, P. J., & DORSEY, G. (2003). DISTINGUISHING RECRUDESCENCE FROM REINFECTION IN A LONGITUDINAL ANTIMALARIAL DRUG EFFICACY STUDY: COMPARISON OF RESULTS BASED ON GENOTYPING OF MSP-1, MSP-2, AND GLURP. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.2003.68.133
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