The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Relapses of Plasmodium vivax Infection Usually Result from Activation of Heterologous Hypnozoites
Open accessAbstract
BACKGROUND: Relapses originating from hypnozoites are characteristic of Plasmodium vivax infections. Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection. It has been assumed that parasites causing relapse would be a subset of the parasites that caused the primary infection. METHODS: Paired samples were collected before initiation of antimalarial treatment and at recurrence of parasitemia from 149 patients with vivax malaria in Thailand (n=36), where reinfection could be excluded, and during field studies in Myanmar (n=75) and India (n=38). RESULTS: Combined genetic data from 2 genotyping approaches showed that novel P. vivax populations were present in the majority of patients with recurrent infection (107 [72%] of 149 patients overall [78% of patients in Thailand, 75% of patients in Myanmar {Burma}, and 63% of patients in India]). In 61% of the Thai and Burmese patients and in 55% of the Indian patients, the recurrent infections contained none of the parasite genotypes that caused the acute infection. CONCLUSIONS: The P. vivax populations emerging from hypnozoites commonly differ from the populations that caused the acute episode. Activation of heterologous hypnozoite populations is the most common cause of first relapse in patients with vivax malaria.
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Cites
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Self-citationResistance to Chloroquine by Plasmodium vivax in Irian Jaya, Indonesia
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Self-citationVivax malaria resistant to treatment and prophylaxis with chloroquine
Murphy, G. S., Basri, H., Andersen, E. M., Bangs, M. J., Gorden, J., Sorensen, K., Mount, D. L., Lal, A. A., Purwokusumo, A. R., Harjosuwarno, S., et al. (1993) · The Lancet · doi:10.1016/0140-6736(93)92568-e · Cited by 209
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Self-citationTherapeutic Responses to Different Antimalarial Drugs in Vivax Malaria
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Comparative genomics of the neglected human malaria parasite Plasmodium vivax
Carlton, J. M., Adams, J. H., Silva, J. C., Bidwell, S. L., Lorenzi, H., Caler, E., Crabtree, J., Angiuoli, S. V., Merino, E. F., Amedeo, P., et al. (2008) · Nature · doi:10.1038/nature07327 · Cited by 835
Self-citationAntimalarial Drug Resistance: A Threat to Malaria Elimination
Menard, D., & Dondorp, A. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025619 · Cited by 499
Plasmodium—a brief introduction to the parasites causing human malaria and their basic biology
Sato, S. (2021) · Journal of Physiological Anthropology · doi:10.1186/s40101-020-00251-9 · Cited by 404
Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis
Price, R. N., von Seidlein, L., Valecha, N., Nosten, F., Baird, J. K., & White, N. J. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70855-2 · Cited by 388
Self-citationResistance to Therapies for Infection by Plasmodium vivax
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Metadata
- Authors
- Imwong, M., Snounou, G., Pukrittayakamee, S., Tanomsing, N., Kim, J. R., Nandy, A., Guthmann, J., Nosten, F., Carlton, J., Looareesuwan, S., Nair, S., Sudimack, D., Day, N. P. J., Anderson, T. J. C., & White, N. J.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04
- Volume
- 195
- Issue
- 7
- Pages
- 927-933
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2124740902
- Cited by
- 294
- References
- 20
- FWCI
- 16.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Imwong, M., Snounou, G., Pukrittayakamee, S., Tanomsing, N., Kim, J. R., Nandy, A., Guthmann, J., Nosten, F., Carlton, J., Looareesuwan, S., Nair, S., Sudimack, D., Day, N. P. J., Anderson, T. J. C., & White, N. J. (2007). Relapses of Plasmodium vivax Infection Usually Result from Activation of Heterologous Hypnozoites. The Journal of Infectious Diseases. https://doi.org/10.1086/512241
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