A COMPARISON OF SULFADOXINE-PYRIMETHAMINE WITH CHLOROQUINE AND PYRIMETHAMINE FOR PREVENTION OF MALARIA IN PREGNANT NIGERIAN WOMEN
Abstract
Few studies have documented the effectiveness in west Africa of intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine (SP) in pregnancy. Pregnant Nigerian women were assigned to receive either SP given twice or presumptive chloroquine (CQ) treatment followed by weekly pyrimethamine (CQ + P); 250 were enrolled in each group. Of those completing follow-up, 4 (1.8%) in the SP group and 22 (9.8%) in the CQ + P groups had a febrile illness (P = 0.005). None in the SP group but 11 (4.9%) in the CQ + P group had peripheral parasitemia prior to or during delivery (P = 0.002). Two (1.2%) in the SP group and 9 (5.0%) in the CQ + P group were anemic at delivery (P = 0.04). There were six low birth weight infants in the SP group and eight in the CQ + P group (P = 0.21). Intermittent preventive treatment with SP is superior to CQ + P for prevention of malaria and anemia in pregnant women in Nigeria.
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In stable transmission settings, many trials have shown that SP given as IPTp is efficacious in preventing the adverse consequences of malaria during pregnancy.
“In stable transmission settings, many trials have shown that SP given as IPTp is efficacious in preventing the adverse consequences of malaria during pregnancy (Table 3).100–104”
From Malaria in pregnancy. (2013) · cites this paper as [103]
Cites
Kayentao, K., Kodio, M., Newman, R. D., Maiga, H., Doumtabe, D., Ongoiba, A., Coulibaly, D., Keita, A. S., Maiga, B., Mungai, M., et al. (2005) · The Journal of Infectious Diseases · doi:10.1086/426400 · Cited by 162 · see citing works
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Takem, E. N., & D'Alessandro, U. (2013) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2013.010 · Cited by 185 · see citing works
- Authors
- TUKUR, I. U., THACHER, T. D., SAGAY, A. S., & MADAKI, J. K. A.
- Affiliations
- Jos University Teaching Hospital (NG)
- Corresponding author
- THACHER, TOM D.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2007-06
- Volume
- 76
- Issue
- 6
- Pages
- 1019-1023
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2795602188
- Cited by
- 21
- References
- 1
- Citations by year
- 2021: 2 · 2020: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 2
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Travel-related health issues
- Keywords
- sulfadoxine-pyrimethamine, chloroquine, pyrimethamine, intermittent preventive treatment, malaria in pregnancy, febrile illness, anemia in pregnancy, low birth weight, Nigerian women
- MeSH terms
- Adult, Animals, Antimalarials, Birth Weight, Chloroquine, Drug Combinations, Female, Hematocrit, Humans, Infant, Newborn, Nigeria, Plasmodium falciparum, Pregnancy, Pyrimethamine, Sulfadoxine, Pregnancy Complications, Parasitic, Malaria, Falciparum, Parasitemia
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