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Cited by 162Malaria Research and ControlGlobal Maternal and Child HealthHemoglobinopathies and Related Disorders

Comparison of Intermittent Preventive Treatment with Chemoprophylaxis for the Prevention of Malaria during Pregnancy in Mali

Kayentao, Kassoum, Kodio, Mamoudou, Newman, Robert D., Maiga, Hamma, Doumtabe, Didier, Ongoiba, Aissata, Coulibaly, Drissa, Keita, Abdoul Salam +4 more·2005·The Journal of Infectious Diseases
DOI 10.1086/426400
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Abstract

BACKGROUND: Malaria during pregnancy contributes to maternal anemia and low birth weight. In East Africa, several studies have demonstrated that intermittent preventive treatment (IPT) with sulfadoxine-pyrimethamine (SP) is more efficacious than weekly chloroquine (CQ) chemoprophylaxis in preventing these adverse consequences. To our knowledge, there are no published trials evaluating IPT in West Africa. METHODS: We undertook a randomized controlled trial of weekly CQ chemoprophylaxis, 2-dose IPT with CQ, and 2-dose IPT with SP; 1163 women were enrolled. RESULTS: In multivariate analyses, when compared with weekly CQ, IPT/SP was associated with a reduction in third-trimester anemia (adjusted odds ratio [AOR], 0.49; P<.001), placental parasitemia (AOR, 0.69; P=.04), and low birth weight (<2500 g) (AOR, 0.69; P=.04). The prevalence of placental infection remained unexpectedly high, even in the IPT/SP group (24.5%), possibly because of the intensity of seasonal transmission. There were no significant differences in stillbirths, spontaneous abortions, or neonatal deaths among the 3 groups. CONCLUSIONS: In Mali, IPT with SP appears more efficacious than weekly chloroquine chemoprophylaxis in preventing malaria during pregnancy. These data support World Health Organization recommendations to administer at least 2 doses of IPT during pregnancy. In intensely seasonal transmission settings in Mali, >2 doses may be required to prevent placental reinfection prior to delivery.

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Crossref · 10.1086/426400

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  • Preventing malaria infection by intermittent preventive treatment during pregnancy reduces the risk of anaemia.

    “Preventing malaria infection by intermittent preventive treatment during pregnancy (IPTp) reduces the risk of anaemia.27,37–38”

    From Malaria in pregnancy. (2013) · cites this paper as [38]

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Authors
Kayentao, K., Kodio, M., Newman, R. D., Maiga, H., Doumtabe, D., Ongoiba, A., Coulibaly, D., Keita, A. S., Maiga, B., Mungai, M., Parise, M. E., & Doumbo, O.
Affiliations
  • University of Bamako (ML)
  • Centers for Disease Control and Prevention (US)
Corresponding author
Newman, Robert D.
ORCID
Venue
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2005-01
Volume
191
Issue
1
Pages
109-116
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1086/426400
OpenAlex
W2153401529
Cited by
162
References
30
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 8 · 2018: 2 · 2017: 3 · 2016: 8 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 14
FWCI
11.36
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • United States Agency for International Development
  • Centers for Disease Control and Prevention
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Global Maternal and Child Health
  • Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
Keywords
malaria in pregnancy, intermittent preventive treatment, sulfadoxine-pyrimethamine, anemia in pregnancy, low birth weight, seasonal malaria transmission, Mali
MeSH terms
Abortion, Spontaneous, Adolescent, Adult, Anemia, Birth Weight, Chloroquine, Drug Administration Schedule, Drug Combinations, Female, Humans, Infant, Infant, Newborn, Malaria, Mali, Placenta Diseases, Pregnancy, Pregnancy Outcome, Pyrimethamine, Sulfadoxine, Pregnancy Complications, Parasitic, Multivariate Analysis, Parasitemia, Chemoprevention

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