The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Artemisinin-Based Combination Treatment of Falciparum Malaria
Abstract
Artemisinin-based combination treatments (ACTs) are now generally accepted as the best treatments for uncomplicated falciparum malaria. They are rapidly and reliably effective. Efficacy is determined by the drug partnering the artemisinin derivative and, for artesunate–mefloquine, artemether–lumefantrine, and dihydroartemisinin–piperaquine, this usually exceeds 95%. Artesunate–sulfadoxine–pyrimethamine and artesunate–amodiaquine are effective in some areas, but in other areas resistance to the partner precludes their use. There is still uncertainty over the safety of artemisinin derivatives in the first trimester of pregnancy, when they should not be used unless there are no effective alternatives. Otherwise, except for occasional hypersensitivity reactions, the artemisinin derivatives are safe and remarkably well tolerated. The adverse effect profiles of the artemisinin-based combination treatments are determined by the partner drug. Most malaria endemic countries have now adopted artemisinin-based combination treatments as first-line treatment of falciparum malaria, but in most of these only a minority of the patients that need artemisinin-based combination treatments actually receive them.
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White, N. J. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421682 · Cited by 1,248
Self-citationAssessment of the pharmacodynamic properties of antimalarial drugs in vivo
White, N. J. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.7.1413 · Cited by 575
Self-citationArtesunate combinations for treatment of malaria: meta-analysis
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Self-citationAntimalarial Drug Toxicity: A Review
Taylor, W. R. J., & White, N. J. (2004) · Drug Safety · doi:10.2165/00002018-200427010-00003 · Cited by 482
Self-citationAntimalarial drug resistance and combination chemotherapy
White, N. (1999) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1999.0426 · Cited by 477
Self-citationEffects of artemisinin derivatives on malaria transmissibility
Price, R. N., Nosten, F., Luxemburger, C., ter Kuile, F. O., Paiphun, L., Price, R. N., Luxemburger, C., Chongsuphajaisiddhi, T., White, N. J., Price, R. N., et al. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91488-9 · Cited by 462
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Clinical Pharmacokinetics and Pharmacodynamics of Artemether-Lumefantrine
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Worthington, R. J., & Melander, C. (2013) · Trends in Biotechnology · doi:10.1016/j.tibtech.2012.12.006 · Cited by 625
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Kirby, J., & Keasling, J. D. (2009) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.043008.091955 · Cited by 478
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Efficacy of RTS,S/AS01E Vaccine against Malaria in Children 5 to 17 Months of Age
Bejon, P., Lusingu, J., Olotu, A., Leach, A., Lievens, M., Vekemans, J., Mshamu, S., Lang, T., Gould, J., Dubois, M.-C., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807381 · Cited by 417
Delves, M., Plouffe, D., Scheurer, C., Meister, S., Wittlin, S., Winzeler, E. A., Sinden, R. E., & Leroy, D. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001169 · Cited by 377
Metadata
- Authors
- Nosten, F., & White, N. J.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2007-12
- Volume
- 77
- Issue
- 6_Suppl
- Pages
- 181-192
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2111813303
- Cited by
- 673
- References
- 82
- FWCI
- 36.49
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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