Liver biochemical abnormalities in adolescent patients with Turner syndrome
Open accessAbstract
Objective: Elevated liver function tests (LFTs) are common in adult Turner syndrome (TS) patients. Data regarding children and adolescents are lacking. To investigate the prevalence of abnormal LFTs in children and adolescents with TS during several years of observation; to evaluate the potential impact of increased body mass index (BMI) and sex hormone replacement therapy (HRT) on LFTs. Methods: The analysis included 100 girls with TS, aged 4-16 years, all of whom were receiving recombinant human growth hormone therapy. A longitudinal study was conducted which included 81 patients. Results: Mean BMI-standard deviation (SD) score of the subjects was 0.63 (SD: 1.53). Forty-four were being treated with HRT. Elevated LFTs were found in 34% of the patients overall (32% not receiving HRT vs 36% on HRT). The relative risk of increased LFTs was not higher in obese vs normal weight [odds ratio (OR): 0.2; 95% confidence interval (CI): 0.1-0.36, p=0.38 vs OR: 0.16; 95% CI: 0.08-0.3, p=0.1]. HRT did not increase the risk of abnormal LFTs activity (OR: 0.8; 95% CI: 0.5-1.2, p=0.37 vs OR: 0.7; 95% CI: 0.4-1.1, p=0.27). During the follow-up period (mean±SD=4.31±0.82 years), no patient developed overt liver disease. There was no significant increase nor decrease of abnormal LFT frequency in the subsequent years of follow up. Conclusion: Constantly elevated LFTs in TS are common in children and adolescents with TS. However the causes and clinical significance remain unclear. This study suggests that obesity and HRT do not increase the risk of elevated LFTs.
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There is no evidence of liver toxicity from E2 treatment.
“No evidence of liver toxicity”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [350]
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- Authors
- Wójcik, M., Ruszała, A., Januś, D., & Starzyk, J. B.
- Affiliations
- Jagiellonian University (PL)
- Corresponding author
- Wójcik, Małgorzata
- Venue
- Journal of Clinical Research in Pediatric Endocrinology
- Publisher
- Galenos Yayinevi
- Published
- 2019-12-01
- Volume
- 11
- Issue
- 4
- Pages
- 395-399
- ISSN
- 1308-5727 (ISSN-L)
- 1308-5735
- PMC
- PMC6878342
- OpenAlex
- W2945658325
- Cited by
- 13
- References
- 45
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 1
- FWCI
- 0.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Journal of Clinical Research in Pediatric Endocrinology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- Turner syndrome, liver function tests, adolescents, sex hormone replacement therapy, body mass index, obesity, recombinant human growth hormone, longitudinal follow-up
- MeSH terms
- Adolescent, Alanine Transaminase, Aspartate Aminotransferases, Child, Child, Preschool, Female, Humans, Liver, Liver Diseases, Liver Function Tests, Longitudinal Studies, Predictive Value of Tests, Progestins, Prospective Studies, Recombinant Proteins, Retrospective Studies, Risk Factors, Time Factors, Turner Syndrome, Biomarkers, Up-Regulation, Estrogen Replacement Therapy, Body Mass Index, Prevalence, Treatment Outcome, Human Growth Hormone, Pediatric Obesity
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