Cited by 15Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsAdvancements in Transdermal Drug Delivery

Preparation of N, N, N-trimethyl chitosan-functionalized retinoic acid-loaded lipid nanoparticles for enhanced drug delivery to glioblastoma

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Liu, Jian-Li, Li, Jie, Zhang, Ling-Yan, Zhang, Pei-Li, Zhou, Jun-Lin, Liu, Bin·2017·Tropical Journal of Pharmaceutical Research

Abstract

Purpose: To formulate trimethyl chitosan-functionalized retinoic acid-encapsulated solid lipid nanoparticles for the effective treatment of glioma.Methods: Retinoic acid-loaded solid lipid nanoparticles (R-SLNs) were prepared using homogenization followed by sonication. R-SLN surfaces were functionalized electrostatically with trimethyl chitosan as a nanocarrier (TR-SLNs) with enhanced anti-cancer activity. They were evaluated by dynamic light scattering (DLS), scanning electron microscopy, in vitro drug release, and cell cytotoxicity and apoptosis studies.Results: Morphological images showed spherical and uniformly dispersed nanoparticles. A sustained monophasic release pattern was observed throughout the study period. Furthermore, the anti-cancer effect of TR-SLNs was demonstrated by increased cell killing activity compared with the free drug (p < 0.01); negligible cytotoxicity was observed with blank carriers. Apoptosis assay showed increased cell populations in early/late apoptotic and necrotic phases.Conclusion: This study showed the potential application of surface-modified solid lipid nanoparticles for the effective treatment of brain cancer.Keywords: Lipid nanoparticles, Trimethyl chitosan, Retinoic acid, Glioma, Anti-cancer, Cytotoxicity, Apoptosis

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  1. Rajadhyaksha M, Boyden T, Liras J, El-Kattan A, and Brodfuehrer J. Current advances in delivery of biotherapeutics across the blood-brain barrier. Curr. Drug Discovery Technol. 2011; 8: 87-101.
  2. Fang J, Chen SJ, Tong JH, Wang ZG. Treatment of acute promyelocytic Leukemia with ATRA and As2O3: a model of molecular. Cancer Biol Ther 2002; 1: 614-620.
  3. Ruttala HB, Ramasamy T, Shin BS, Choi HG, Yong CS, Kim JO. Layer-by-Layer Assembly of Hierarchical Nanoarchitectures to Enhance the Systemic Performance of Nanoparticle Albumin-bound Paclitaxel Int. J. Pharm 2017; 519: 11-21.

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Authors
Liu, J.-L., Li, J., Zhang, L.-Y., Zhang, P.-L., Zhou, J.-L., & Liu, B.
Affiliations
  • Lanzhou University (CN)
  • Lanzhou University Second Hospital (CN)
Venue
Tropical Journal of Pharmaceutical Research
Published
2017-09-06
Volume
16
Issue
8
Pages
1765
ISSN
  • 1596-5996 (ISSN-L)
  • 1596-9827
OpenAlex
W2752704617
Cited by
15
References
19
Citations by year
2026: 1 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 1 · 2020: 4 · 2019: 1
FWCI
0.49
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
Tropical Journal of Pharmaceutical Research (publishedVersion, cc-by)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords
retinoic acid, solid lipid nanoparticles, trimethyl chitosan, glioblastoma, glioma, drug delivery, sustained drug release, apoptosis, cytotoxicity, brain cancer

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