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Cited by 11Oral microbiology and periodontitis researchPeriodontal Regeneration and TreatmentsDental Research and COVID-19

Efficacy of non-surgical periodontal treatment on patients with coronary artery disease: a meta-analysis of randomized controlled trials

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Liu, C., Shi, F., Li, W., Chen, J.·2022·Medicina Oral Patología Oral y Cirugia Bucal
DOI 10.4317/medoral.25514PMC PMC9648645
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Abstract

BACKGROUND: Coronary artery disease (CAD) is defined as one of the most common cardiovascular diseases (CVDs). Periodontitis is one of the risk factors for CAD. MATERIAL AND METHODS: PubMed, Embase and Cochrane Library databases were carefully and thoroughly retrieved until October 2021. On the basis of the inclusion and exclusion criteria, eligible articles were selected strictly to identify randomized controlled trials (RCTs). Using Cochran's Q statistic, Review Manager 5.4 and Stata 16, data were extracted, and a comprehensive analysis was carried out. RESULTS: Six RCTs of 619 patients were included in this study, including 360 in the intervention group (IG) and 259 in the control group (CG). Meta-analysis showed significant difference for C-reactive protein (CRP) (1.20mg/L, 95% CI: 1.13 to 1.27, p < 0.00001) after non-surgical periodontal therapy (NSPT), but showed no significant difference for interleukin-6 (IL-6) (1.19mg/L, 95% CI: -1.03 to 3.40, p=0.29), flow-mediated dilation (FMD) (-1.64%, 95% CI: -4.95 to 1.67, p=0.33), triacylglycerol (TG) (-0.02mg/dL, 95% CI: -0.31 to 0.27, p=0.90), total cholesterol (TC) (0.04mg/dL, 95% CI: -0.25 to 0.33, p=0.90), low-density lipoprotein cholesterol (LDL-C) (0.00mg/dL, 95% CI: -0.29 to 0.29, p=0.99) and high-density lipoprotein cholesterol (HDL-C) (0.11mg/dL, 95% CI: -0.18 to 0.40, p=0.46). CONCLUSIONS: The impact of NSPT on the reduction of CRP in patients of CAD with periodontitis is significant. NSPT can be considered as an important preventive strategy for major cardiovascular events in CAD.

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Cited by

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Authors
Liu, C., Shi, F., Li, W., & Chen, J.
Affiliations
Central South University (CN)
Corresponding author
Chen, J.
Venue
Medicina Oral Patología Oral y Cirugia Bucal
Publisher
Medicina Oral, S.L.
Published
2022
Volume
27
Issue
6
Pages
e578-e587
ISSN
  • 1698-4447 (ISSN-L)
  • 1698-6946
DOI
10.4317/medoral.25514
PMC
PMC9648645
OpenAlex
W4306362031
Cited by
11
References
2
Citations by year
2025: 3 · 2024: 7 · 2023: 1
FWCI
0.51
Type
journal article
Language
en
Open access
Locations
  • Medicina oral, patología oral y cirugía bucal (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, cc-by-nc)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
  • Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
Keywords
non-surgical periodontal therapy, coronary artery disease, periodontitis, C-reactive protein, interleukin-6, flow-mediated dilation, lipid profile, cardiovascular risk factors, cardiovascular event prevention, inflammatory markers, endothelial function, LDL cholesterol, HDL cholesterol, triglycerides, total cholesterol, dyslipidemia
MeSH terms
C-Reactive Protein, Coronary Artery Disease, Humans, Cholesterol, HDL, Cholesterol, LDL, Triglycerides, Randomized Controlled Trials as Topic

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