Periodontal treatment on patients with cardiovascular disease: Systematic review and meta-analysis
Open accessAbstract
BACKGROUND: Atherosclerotic cardiovascular disease is the main cause of mortality in developed countries. It is a chronic and systemic inflammatory disease with a multifactorial etiology. Periodontal disease is one of the many factors that contribute to its development. OBJECTIVE: To analyze the effects of periodontal treatment on cardiovascular risk parameters in patients with atherosclerotic cardiovascular disease. METHODS: A systematic research was conducted in the Pubmed/Medline databases for clinical trials published up to and including the year 2017. RESULTS: Ten articles were included for analysis. Periodontal treatment reduced C-reactive protein levels (77.8% of clinical trials), tumor necrosis factor-alpha (66.7%), interleukin-6 (100%) and leukocytes (50%). Fibrinogen levels also improved considerably (66.7%). Effects on lipid parameters were more limited, whereby only oxidized low density lipoprotein and very low density lipoprotein cholesterol decreased significantly. Meta-analysis showed a statistically significant decreased in C-reactive protein and leukocytes values when patients were submitted to non-surgical periodontal treatment in contrast to receiving no treatment at all (mean difference 1.199 mg/L, 95% confidence interval: 1.100-1.299, p<0.001; and mean difference 0,79 g/L, 95% confidence interval: 0.717-0.879, p<0.001, respectively). CONCLUSIONS: Periodontal treatment has a beneficial effect on some of the biochemical parameters considered to represent cardiovascular risk. Further randomized clinical trials are necessary, with longer follow-up periods including regular periodic monitoring, in order to determine the extent of the impact of periodontal treatment.
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A previous meta-analysis found NSPT unrelated to improvements in LDL, HDL-C, TC, and TG levels.
“A previous meta-analysis [75, 77] found that, NSPT would appear unrelated to improvements in LDL, HDL-C, TC, and TG levels, consistent with our findings.”
From Effect of non-surgical periodontal therapy on risk markers of cardiovascular disease: a systematic review and meta-analysis (2024) · cites this paper as [75]
The Discussion reports no significant improvement in total cholesterol, HDL-C or triglycerides after periodontal treatment, but says LDL-C decreased significantly in one study. The lipid findings come from the review of included studies; the paper's pooled meta-analysis addressed CRP and leukocytes, not these lipid measures. The claim therefore overstates both the LDL-C finding and what the meta-analysis tested. (LLM, conf=0.91)
Experimental — accuracy not yet measuredThe majority of previously relevant meta-analyses only included periodontitis patients with specific systemic health conditions, such as CVD, CAD, hypertension and diabetes.
“In contrast, the majority of previously relevant meta analyses only included periodontitis patients with specific systemic health conditions, such as CVD [75], CAD [76], hypertension [77] and diabetes [78].”
From Effect of non-surgical periodontal therapy on risk markers of cardiovascular disease: a systematic review and meta-analysis (2024) · cites this paper as [75]
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- Authors
- Roca-Millan, E., Gonzalez-Navarro, B., Sabater-Recolons, M., Mari-Roig, A., Jane-Salas, E., & Lopez-Lopez, J.
- Affiliations
- Universitat de Barcelona (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Corresponding author
- Lopez-Lopez, J
- Venue
- Medicina Oral Patología Oral y Cirugia Bucal
- Publisher
- Medicina Oral, S.L.
- Published
- 2018
- Volume
- 23
- Issue
- 6
- Pages
- 0-0
- ISSN
- 1698-4447 (ISSN-L)
- 1698-6946
- PMC
- PMC6261003
- OpenAlex
- W2897565315
- Cited by
- 54
- References
- 39
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 10 · 2023: 4 · 2022: 16 · 2021: 9 · 2020: 5 · 2019: 4
- FWCI
- 0.66
- Type
- journal article
- Language
- es
- Open access
- diamond
- doi.org
- Locations
- Medicina oral, patología oral y cirugía bucal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, public-domain)
- Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
- Keywords
- periodontal treatment, atherosclerotic cardiovascular disease, cardiovascular risk factors, C-reactive protein, TNF-α, interleukin-6, fibrinogen, leukocytes, oxidized LDL, VLDL cholesterol, systemic inflammation, non-surgical periodontal therapy
- MeSH terms
- Cardiovascular Diseases, Humans, Periodontal Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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