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Clinical Effects of Chlorella in Hypertensive Men.
Open accessAbstract
非薬物療法で経過観察可能と判断された軽症ないし境界域一次性高血圧患者23名を対象にした, クロレラの投与試験を実施した。患者のうちクロレラの摂取を理解し積極的に協力してくれた13名に, 他養的に純粋培養したクロレラを毎日1.5g, 6カ月間投与した (クロレラ群)。他の10名は生活指導のみによる経過観察とした (対照群)。両群の高血圧症関連の諸臨床症候の推移を観察し, 以下の結果を得た。1) クロレラ群は, 摂取3カ月後から収縮期血圧および拡張期血圧が有意に低下した。試験前値に比べ6カ月後の血圧下降度は, 収縮期血圧が14.1±1.9mmHg, 拡張期血圧が6.3±1.8mmHgであった。「降圧薬の臨床評価方法に関するガイドライン」に示された降圧度判定基準によると, クロレラ群13例中3例が「下降」, 5例が「下降傾向」, 5例が「不変」であった。一方, 対照群では, 試験期間中血圧の有意な変化は見られなかった。2) クロレラ摂取の前後に行ったアンケート調査から, 高血圧症関連の愁訴の減少と全体的な体調の改善が見られた。3) クロレラの摂取による副作用は, アンケート調査, 臨床検査から認められなかった。以上の結果から, クロレラの摂取は軽症の高血圧症の改善に有効であることが示唆された。
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Long-term supplementation with Chlorella (approximately 1.5 g/day for up to six months) reduces blood pressure in hypertensive and borderline hypertensive adults, with enhanced effects reported for GABA-enriched formulations.
“Similarly, long-term supplementation with Chlorella (approximately 1.5 g/day for up to six months) has been shown to reduce blood pressure in hypertensive and borderline hypertensive adults, with enhanced effects reported for GABA-enriched formulations [77,78].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [77]
The study summary and results report that 1.5 g/day of Chlorella for six months lowered blood pressure in men with mild or borderline hypertension. The paper does not report an enhanced effect from GABA-enriched formulations, and its findings do not establish the effect in adults generally. (LLM, conf=0.88)
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Citations
Cited by
Sorted by citations
Suetsuna, K., & Chen, J. (2001) · Marine Biotechnology · doi:10.1007/s10126-001-0012-7 · Cited by 219
“Inoue et al. (1995) reported that ingestion of Chlorella decreases blood pressure in humans.”
BackgroundAntioxidant and Anti-Cataract Effects of Chlorella on Rats with Streptozotocin-Induced Diabetes
Shibata, S., NATORI, Y., NISHIHARA, T., Tomisaka, K., Matsumoto, K., Sansawa, H., & Nguyễn, V. C. (2003) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.49.334 · Cited by 96
Self-citationFallah, A. A., Sarmast, E., Saied, H. D., Engardeh, J., Mahmoodnia, L., Khaledifar, A., & Jafari, T. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.09.019 · Cited by 80
Zhao, C., Wu, Y., Yang, C., Liu, B., & Huang, Y. (2015) · International Journal of Food Science & Technology · doi:10.1111/ijfs.12860 · Cited by 69
Nakano, S., Takekoshi, H., & Nakano, M. (2009) · Plant Foods for Human Nutrition · doi:10.1007/s11130-009-0145-9 · Cited by 56
“In addition, several studies have demonstrated that Chlorella intake improved iron deficiency anemia in rats [13], and suppressed elevation of blood pressure in rat models or human subjects [14].”
BackgroundShibata, S., HAYAKAWA, K., Egashira, Y., & Sanada, H. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.60566 · Cited by 54
Medicinal Effects of Peptides from Marine Microalgae
Kim, S., & Kang, K. (2011) · Advances in food and nutrition research · doi:10.1016/b978-0-12-387669-0.00025-9 · Cited by 47
Hypocholesterolemic Effect of Indigestible Fraction of Chlorella regularis in Cholesterol-Fed Rats.
Shibata, S., Kuniaki, O. D. A., Masuoka, N., MATSUBARA, S., KIKUCHI-HAYAKAWA, H., Ishikawa, F., Iwabuchi, A., & Sansawa, H. (2001) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.47.373 · Cited by 46
Self-citationJiang, Q., Chen, Q., Zhang, T., Liu, M., Duan, S., & Sun, X. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084068 · Cited by 47
“Chlorella was also shown to decrease human blood pressure after ingestion [48].”
BackgroundSherafati, N., Bideshki, M. V., Behzadi, M., Mobarak, S., Asadi, M., & Sadeghi, O. (2022) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2022.102822 · Cited by 32
Sansawa, H., Takahashi, M., Tsuchikura, S., & Endô, H. (2006) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.52.457 · Cited by 30
Self-citationCheng, F., Lin, A., Feng, J.-J., et al. (2004) · Journal of Medicinal Food · doi:10.1089/1096620041224076 · Cited by 25
Son, Y. A., Shim, J. A., Hong, S., & Kim, M. K. (2009) · Annals of Nutrition and Metabolism · doi:10.1159/000199453 · Cited by 17
Cheng, F., Feng, J.-J., Chen, K.-H., et al. (2009) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637480802225512 · Cited by 9
“…and Chlorella extracts have been documented to have a variety of pharmacological effects, including improving hypertension (Murakami et al. 1987; Inoue et al. 1995), lipid metabolism (Shibata et al. 1998), enhancing anti-tumor (Tanaka et al. 1984; Konishi et al. 1985; Miyazawa et al. 1988),…”
BackgroundKhaliq, M., Noor, Z., Moazzam, M., Saeed, F., Tul-Zohra, K., Tariq, E., Muhammad Shahbaz, H., & Khaliq, K. (2026) · Annals of Medicine · doi:10.1080/07853890.2026.2637282 · Cited by 4
“Similarly, long-term supplementation with Chlorella (approximately 1.5 g/day for up to six months) has been shown to reduce blood pressure in hypertensive and borderline hypertensive adults, with enhanced effects reported for GABA-enriched formulations [77,78].”
InfluentialCheng, F., Feng, J.-J., Chen, K., Imanishi, H., Fujishima, M., Takekoshi, H., Naoki, Y., & Shimoda, M. (2009) · Phytotherapy Research · doi:10.1002/ptr.2864 · Cited by 5
“As the subject of numerous studies, Chlorella and Chlorella extracts have been documented to have a variety of pharmacological effects, including improving hypertension (Inoue et al., 1995; Murakami et al., 1987), lipid metabolism (Shibata et al.”
BackgroundDifferential Handling of Toxic Chemicals by Stress Shock Algae
Yu, H.-Y., Wang, S., Cai, Z., & Poon, K. (2012) · International Journal of Environmental Pollution and Remediation · doi:10.11159/ijepr.2012.016 · Cited by 2
“Other functions included antihypertension (Inoue et al 1995), immunemodulation (Itoh et al 1993).”
Shiri, H., Taheri, A. T., Soleimani, A. A., Nematollahi, M. H., Meshkani, R., Panahi, G., Tabatabaei‐Malazy, O., & Larijani, B. (2025) · Algal Research · doi:10.1016/j.algal.2025.104281 · Cited by 1
Jafari, A., Mardani, H., Mahmoudinezhad, M., Karimi, M. A., Musazadeh, V., & Sharifi, M. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71715
“Additional inaccuracies, including misreporting of sample sizes (Inoue et al. 1995) and erroneous classification of study durations (Nakano et al. 2010), further compromised the statistical validity of their conclusions.”
Metadata
- Authors
- INOUE, K., MUKAIYAMA, Y., OKA, H., & SANSAWA, H.
- Affiliations
- Yakult Central Institute (JP)
- Venue
- Nippon Eiyo Shokuryo Gakkaishi
- Published
- 1995
- Volume
- 48
- Issue
- 6
- Pages
- 485-489
- ISSN
- 0287-3516 (ISSN-L)
- 1883-2849
- OpenAlex
- W2328408082
- Cited by
- 20
- References
- 0
- Citations by year
- 2026: 3 · 2025: 1 · 2022: 1 · 2021: 1 · 2017: 1 · 2015: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- ja
- Open access
- diamond
- doi.org
- Locations
- Nippon Eiyo Shokuryo Gakkaishi (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- Chlorella, hypertension, essential hypertension, dietary supplementation, blood pressure reduction, non-pharmacological treatment, men, lifestyle advice, adverse effects
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