Cited by 345Alcohol Consumption and Health EffectsBlood Pressure and Hypertension StudiesNitric Oxide and Endothelin Effects

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Alcohol-induced hypertension: Mechanism and prevention

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Husain, Kazim, Ansari, Rais A, Ferder, Leon·2014·World Journal of Cardiology

DOI 10.4330/wjc.v6.i5.245PMC PMC4038773

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Abstract

Epidemiological, preclinical and clinical studies established the association between high alcohol consumption and hypertension. However the mechanism through which alcohol raises blood pressure remains elusive. Several possible mechanisms have been proposed such as an imbalance of the central nervous system, impairment of the baroreceptors, enhanced sympathetic activity, stimulation of the renin-angiotensin-aldosterone system, increased cortisol levels, increased vascular reactivity due to increase in intracellular calcium levels, stimulation of the endothelium to release vasoconstrictors and loss of relaxation due to inflammation and oxidative injury of the endothelium leading to inhibition of endothelium-dependent nitric oxide production. Loss of relaxation due to inflammation and oxidative injury of the endothelium by angiotensin II leading to inhibition of endothelium-dependent nitric oxide production is the major contributors of the alcohol-induced hypertension. For the prevention of alcohol-induced hypertension is to reduce the amount of alcohol intake. Physical conditioning/exercise training is one of the most important strategies to prevent/treat chronic alcohol-induced hypertension on physiological basis. The efficacious pharmacologic treatment includes the angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type 1 receptor blockers (ARBs) which have antioxidant activity and calcium channel blockers. The most effective prevention and treatment of alcohol-induced hypertension is physical exercise and the use of ACE inhibitors or ARBs in the clinic.

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See all 345

Authors: Husain, K., Ansari, R. A., & Ferder, L.
Affiliations: Ponce Health Sciences University (PR)
ORCID: Ansari, Rais A
Venue: World Journal of Cardiology
Publisher: Baishideng Publishing Group Inc.
Published: 2014
Volume: 6
Issue: 5
Pages: 245
ISSN: 1949-8462 (ISSN-L)
DOI: 10.4330/wjc.v6.i5.245
PMC: PMC4038773
OpenAlex: W2147275838
Cited by: 345
References: 114
Citations by year: 2026: 25 · 2025: 41 · 2024: 42 · 2023: 36 · 2022: 33 · 2021: 35 · 2020: 38 · 2019: 33 · 2018: 18 · 2017: 19 · 2016: 17 · 2015: 7 · 2014: 1
FWCI: 2.07
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: World Journal of Cardiology (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
NSUWorks (Nova Southeastern University) (submittedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: alcohol-induced hypertension, alcohol consumption, blood pressure regulation, endothelial dysfunction, nitric oxide, oxidative stress, angiotensin II, renin-angiotensin-aldosterone system, sympathetic nervous system, baroreceptors, exercise training, ACE inhibitors, angiotensin receptor blockers, calcium channel blockers, hypertension prevention

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