The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
Alcohol-induced hypertension: Mechanism and prevention
Open accessAbstract
Epidemiological, preclinical and clinical studies established the association between high alcohol consumption and hypertension. However the mechanism through which alcohol raises blood pressure remains elusive. Several possible mechanisms have been proposed such as an imbalance of the central nervous system, impairment of the baroreceptors, enhanced sympathetic activity, stimulation of the renin-angiotensin-aldosterone system, increased cortisol levels, increased vascular reactivity due to increase in intracellular calcium levels, stimulation of the endothelium to release vasoconstrictors and loss of relaxation due to inflammation and oxidative injury of the endothelium leading to inhibition of endothelium-dependent nitric oxide production. Loss of relaxation due to inflammation and oxidative injury of the endothelium by angiotensin II leading to inhibition of endothelium-dependent nitric oxide production is the major contributors of the alcohol-induced hypertension. For the prevention of alcohol-induced hypertension is to reduce the amount of alcohol intake. Physical conditioning/exercise training is one of the most important strategies to prevent/treat chronic alcohol-induced hypertension on physiological basis. The efficacious pharmacologic treatment includes the angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type 1 receptor blockers (ARBs) which have antioxidant activity and calcium channel blockers. The most effective prevention and treatment of alcohol-induced hypertension is physical exercise and the use of ACE inhibitors or ARBs in the clinic.
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“Nonetheless, heavy alcohol intake (>30–50 g/d) is a well-established risk factor for hypertension.165”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [165]
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Alcohol Abstinence in Drinkers with Atrial Fibrillation
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Metadata
- Authors
- Husain, K., Ansari, R. A., & Ferder, L.
- Affiliations
- Ponce Health Sciences University (PR)
- ORCID
- Ansari, Rais A
- Venue
- World Journal of Cardiology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 6
- Issue
- 5
- Pages
- 245
- ISSN
- 1949-8462 (ISSN-L)
- PMC
- PMC4038773
- OpenAlex
- W2147275838
- Cited by
- 345
- References
- 114
- Citations by year
- 2026: 25 · 2025: 41 · 2024: 42 · 2023: 36 · 2022: 33 · 2021: 35 · 2020: 38 · 2019: 33 · 2018: 18 · 2017: 19 · 2016: 17 · 2015: 7 · 2014: 1
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Cardiology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- NSUWorks (Nova Southeastern University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- alcohol-induced hypertension, alcohol consumption, blood pressure regulation, endothelial dysfunction, nitric oxide, oxidative stress, angiotensin II, renin-angiotensin-aldosterone system, sympathetic nervous system, baroreceptors, exercise training, ACE inhibitors, angiotensin receptor blockers, calcium channel blockers, hypertension prevention
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