Associations among Gastric Juice pH, Atrophic Gastritis, Intestinal Metaplasia and Helicobacter pylori Infection
Open accessAbstract
Background/Aims: Gastric juice plays a crucial role in the physiology of the stomach.The aim of this study is to evaluate associations among the pH of gastric juice, atrophic gastritis (AG), intestinal metaplasia (IM), pepsinogen, and Helicobacter pylori infection.Methods: Gastric biopsies and juice were collected from 46 subjects who underwent endoscopies at Seoul National University Bundang Hospital between November 2011 and March 2013.H. pylori, AG and IM were evaluated, and pepsinogen I or II, I/II ratio, and interleukin (IL)-1β levels were measured.Results: The mean pH of gastric juice was higher in the H. pylori-positive group (n=17) than that in the H. pylori-negative group (n=29) (4.54 vs 2.46, p=0.002).When patients were divided into pH <3 (n=28) and pH ≥3 (n=18) groups, H. pylori was lower in the pH <3 group (21.4%) than in the pH ≥3 group (61.1%) (p=0.007).The pH ≥3 group demonstrated AG and IM more frequently than the pH <3 group in the body (p=0.047 and p=0.051, respectively) but not in the antrum.There were no differences in pepsinogen I or II, I/II ratio, and IL-1β levels between the two groups.Conclusions: There is a relationship between chronic H. pylori infection and gastric juice pH ≥3, which may originate from AG and IM in the body.(Gut Liver 2018;12:158-164)
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When H. pylori infection spreads to the oxyntic mucosa, it causes pangastritis, which is associated with hypochloridria, and is responsible for the development of chronic atrophic gastritis, intestinal metaplasia and, finally, dysplasia and GC.
“In addition, when the infection does spread to the oxyntic mucosa, it causes pangastritis, which is associated with hypochloridria, and is responsible for the development of chronic atrophic gastritis, intestinal metaplasia and, finally, dysplasia and GC[69,70].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [69]
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Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified
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- Authors
- Sung, J., Kim, N., Lee, J., Hwang, Y.-J., Kim, H. W., Chung, J. W., Kim, J.-W., & Lee, D. H.
- Affiliations
- Seoul National University Bundang Hospital (KR)
- Seoul National University (KR)
- Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
- Corresponding author
- Kim, Nayoung
- Venue
- Gut and Liver
- Published
- 2018-03-15
- Volume
- 12
- Issue
- 2
- Pages
- 158-164
- ISSN
- 1976-2283 (ISSN-L)
- 2005-1212
- PMC
- PMC5832340
- OpenAlex
- W2755418138
- Cited by
- 39
- References
- 27
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 8 · 2021: 10 · 2020: 4 · 2019: 2 · 2018: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Gut and Liver (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Research Foundation of Korea(NRF) (2012R1A1B5002680)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gastric Cancer Management and Outcomes
- Keywords
- gastric juice pH, atrophic gastritis, intestinal metaplasia, Helicobacter pylori infection, pepsinogen I/II ratio, IL-1β, gastric body, gastric antrum
- MeSH terms
- Adult, Aged, Female, Gastric Juice, Gastritis, Atrophic, Humans, Hydrogen-Ion Concentration, Intestinal Mucosa, Male, Metaplasia, Middle Aged, Precancerous Conditions, Statistics as Topic, Stomach Neoplasms, Helicobacter pylori, Helicobacter Infections, Pepsinogen A, Republic of Korea
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