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Cited by 63Skin Protection and AgingPhytochemistry and biological activity of medicinal plantsFacial Rejuvenation and Surgery Techniques

Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo

Open access
Cho, Soyun, Lee, Serah, Lee, Min-Jung, Lee, Dong Hun, Won, Chong-Hyun, Kim, Sang Min, Chung, Jin Ho·2009·Annals of Dermatology
DOI 10.5021/ad.2009.21.1.6PMC PMC2883372
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Abstract

BACKGROUND: No studies have yet been undertaken to determine the effect of aloe gel on the clinical signs and biochemical changes of aging skin. OBJECTIVE: We wanted to determine whether dietary aloe vera gel has anti-aging properties on the skin. METHODS: Thirty healthy female subjects over the age of 45 were recruited and they received 2 different doses (low-dose: 1,200 mg/d, high-dose: 3,600 mg/d) of aloe vera gel supplementation for 90 days. Their baseline status was used as a control. At baseline and at completion of the study, facial wrinkles were measured using a skin replica, and facial elasticity was measured by an in vivo suction skin elasticity meter. Skin samples were taken before and after aloe intake to compare the type I procollagen and matrix metalloproteinase 1 (MMP-1) mRNA levels by performing real-time RT-PCR. RESULTS: After aloe gel intake, the facial wrinkles improved significantly (p<0.05) in both groups, and facial elasticity improved in the lower-dose group. In the photoprotected skin, the type I procollagen mRNA levels were increased in both groups, albeit without significance; the MMP-1 mRNA levels were significantly decreased in the higher-dose group. Type I procollagen immunostaining was substantially increased throughout the dermis in both groups. CONCLUSION: Aloe gel significantly improves wrinkles and elasticity in photoaged human skin, with an increase in collagen production in the photoprotected skin and a decrease in the collagen-degrading MMP-1 gene expression. However, no dose-response relationship was found between the low-dose and high-dose groups.

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  • Cho et al. study on oral aloe vera for photoaged skin was uncontrolled and provided Level IV evidence.

    “It was an uncontrolled study using objective measurements on reverse transcription PCR of matrix metalloproteinase 1 mRNA and type 1 procollagen, skin elasticity meter, and skin replica. The authors showed that all the above measures improved with the supplementation of oral aloe vera (Level IV evidence).”

    From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [4]

    The Abstract and Discussion (pages not provided) describe a before-and-after oral aloe study and explicitly acknowledge the lack of a control group, consistent with the citing paper’s Level IV characterization. The Abstract reports improved wrinkles in both dose groups, but improved elasticity only in the lower-dose group; procollagen mRNA increases were not statistically significant, and MMP-1 mRNA decreased significantly only in the higher-dose group. Thus, the citing sentence overstates the results by saying all the measures improved. (LLM, conf=0.87)

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Research works printed but not linked: 3

  1. Shelton RM. Aloe vera. Its chemical and therapeutic pro- perties. Int J Dermatol 1991;30:679-683.
  2. Klein AD, Penneys NS. Aloe vera. J Am Acad Dermatol 1988;18:714-720.
  3. Lindblad WJ, Thul J. Sustained increase in collagen bio- synthesis in acemannan impregnated PVA implants in the rat [abstract]. Wound Repair Regen 1994;2:84.

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Related

Authors
Cho, S., Lee, S., Lee, M.-J., Lee, D. H., Won, C.-H., Kim, S. M., & Chung, J. H.
Affiliations
Seoul National University (KR)
ORCID
Venue
Annals of Dermatology
Publisher
XMLink
Published
2009
Volume
21
Issue
1
Pages
6
ISSN
  • 1013-9087 (ISSN-L)
  • 2005-3894
DOI
10.5021/ad.2009.21.1.6
PMC
PMC2883372
OpenAlex
W2164007823
Cited by
63
References
25
Citations by year
2026: 1 · 2025: 1 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 3
FWCI
1.67
Type
journal article
Language
en
Open access
Licence
Locations
  • Annals of Dermatology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Korea Food and Drug Administration
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
  • Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
Keywords
Aloe vera gel, dietary supplementation, skin aging, facial wrinkles, skin elasticity, type I procollagen, MMP-1, collagen synthesis, dermis, anti-aging

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