A population-based screening for gestational diabetes mellitus in non-diabetic women in Bahrain
Open accessAbstract
BACKGROUND: Maternal hyperglycemia is considered a risk factor for fetal morbidity. Since there is a high prevalence of diabetes mellitus among the population of Bahrain, we conducted a prospective population-based study of gestational diabetes mellitus (GDM) in non-diabetic pregnant women. SUBJECTS AND METHODS: All non-diabetic pregnant women attending antenatal clinics during January 2001 to December 2002 (n=10,495) were screened for GDM during the 24th to 28th weeks of gestation. All positive subjects based on a 50-g glucose challenge test (GCT) were further evaluated by a diagnostic 75-g oral glucose tolerance test (OGTT). The birth weight of the child and post-delivery insulin resistance were monitored. The homeostasis model of insulin resistance (HOMA-IR) was used to assess insulin resistance. RESULTS: Of 10,495 non-diabetic pregnant women screened, 32.8% (n=3443) had plasma glucose > or = 7.8 mmol/L (140 mg/dL) in the GCT. The 75-g OGTT found a prevalence of GDM of 13.5%. There were twice as many Bahrainis as expatriates. Of children born to women with GDM, 6.5% had a birth weight > 4000 g. Post-delivery evaluation of insulin resistance indicated that 33% of women with GDM had a HOMA-IR value > 2. CONCLUSION: The population of Bahrain is a high-risk ethnic group for GDM. The association of insulin resistance in the post-gravid state with GDM among 33% of the study population suggests that insulin resistance, the possible cause of the pathophysiological mechanism underlying the development of gestational diabetes, continues in the post gravid state.
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In Bahrain in 2012, GDM was assessed at 10.1%.
“In 2012, GDM was assessed at 10.1%.”
From Evolution of Gestational Diabetes Mellitus across Continents in 21st Century (2022) · cites this paper as [239]
The Methods describe screening in Bahrain from January 2001 to December 2002, not in 2012. The Results report GDM in 13.3% of the screened non-diabetic pregnant women, rather than 10.1%. The supplied copy gives no page numbers for these sections. (LLM, conf=0.89)
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Experimental — accuracy not yet measuredIn Bahrain, main risk factors for GDM are weight and maternal age.
“The main risk factors are weight and maternal age [239].”
From Evolution of Gestational Diabetes Mellitus across Continents in 21st Century (2022) · cites this paper as [239]
The Discussion lists pre-pregnancy weight and age among several risk factors for GDM, so it supports identifying both as risk factors. It does not identify them as the main risk factors in Bahrain; instead, it emphasizes the Bahraini population’s high-risk ethnic status. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIn Bahrain between 2002 and 2010, GDM detection increased from 7.2% to 12.5%.
“Between 2002 and 2010, there was an increase in GDM detection from 7.2% to 12.5%.”
From Evolution of Gestational Diabetes Mellitus across Continents in 21st Century (2022) · cites this paper as [239]
The Subjects and Methods section describes screening in Bahrain from January 2001 through December 2002, and the Results report a GDM prevalence of 13.3%. Our copy does not report a 2002–2010 trend or detection rates of 7.2% and 12.5% (searched for those figures and the date range). (LLM, conf=0.78)
Experimental — accuracy not yet measured
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Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Jang, H. C., Cho, N. H., Min, Y.-K., Han, I. K., Jung, K. B., & Metzger, B. E. (1997) · Diabetes Care · doi:10.2337/diacare.20.10.1582 · Cited by 86 · see citing works
Flagged first, then by citations
Research works printed but not linked: 21
- [1]Metzer BE Coustan DM Organizing committee Summary and recommendations of Fourth international Workshop. Conference on Gestational diabetes mellitus Diabetes Care 1998 21 suppl 2 B161 B167 9704245
- [2]Catalano PM Kirwan JP Haugel-de Mouzon S King J Gestational diabetes and insulin resistance: role in short- and long-term implications for mother and fetus J Nutr 2003 133 5 Suppl 2 1674S 1683S 12730484
- [3]Kjos SL Buchanan TA Gestational diabetes NEJM 1999 341 1749 56 10580075
- [4]Kuhl C Aetiology of gestational diabetes Baillieres Clin Obstet Gynaecol 1991 6 5 2 279 92 1954714
- [5]National Diabetes Data group Classification and diagnosis of Diabetes mellitus and other categories of glucose intolerance Diabetes 1979 28 1039 57 510803
- [6]Naylor CD Serner M Chen E Sykora K Caesarian delivery in relation to birth weight and gestational glucose tolerance: pathophysiology or practice style JAMA 1996 275 1165 70 8609683
- [7]Davis CL Gutt M Llabre MM Marks JB O’Sullivan MJ Potter JE Landel JL Kumar M Schneiderman N Gellman M Skyler JS History of gestational diabetes, insulin resistance and coronary risk J Diabetes Complications 1999 13 4 216 23 10616862
- [8]Bartha JL Comino-Delgado R Martinez-Del-Fresno P Fernandez-Barrios M Bethencourt I Moreno-Corral L Insulin-sensitivity index, carbohydrate and lipid metabolism in gestational diabetes J Reprod Med 2000 45 3 185 9 10756494
- [9]Tamas G Kerenyi Z Current controversies in the mechanisms and treatment of gestational diabetes Curr Diab Rep 2002 2 4 337 46 12643194
- [10]Vambergue A Valat AS Dufour P Cazaubiel M Fontaine P Puech F Pathophysiology of gestational diabetes J Gynecol Obstet Biol Reprod (Paris) 2002 31 6 Suppl 4S3 4S10 12451352
- [11]Gunton JE Hitchman R McElduff A Effects of ethnicity on glucose tolerance, insulin resistance and beta cell function in 223 women with an abnormal glucose challenge test during pregnancy Aust N Z J Obstet Gynaecol 2001 41 2 182 6 11453268
- [12]Csorba TR Edwards AL The genetics and pathophysiology of type II and gestational diabetes Crit Rev Clin Lab Sci 1995 32 5–6 509 50 8561892
- [13]Schaefer UM Songster G Xiang A Berkowitz K Buchanan TA Kjos SI Congenital malformations in off spring of women with hyperglycemia first detected during pregnancy Am J Obstet Gynaecol 1997 177 1165 71 9396914
- [14]O’Sullivan JB Charles D Mahan CM Dandrow RV Gestational Diabetes and perinatal mortality rate Am J Obstet Gynaecol 1973 116 901 4 4718217
- [16]Persson B Hanson U Neonatal morbidities in gestational diabetes mellitus Diabetes Care 1998 21 Suppl 2 B79 B84 9704232
- [19]Sermer M Naylor CD Gare DJ Impact of increasing carbohydrate intolerance on maternal fetal outcomes in 3637 without gestational diabetes: the Toronto Tri Hospital gestational diabetes project Am J Obstet Gynecol 1995 173 146 156 7631672
- [20]Tsutomu K Akira K Keiko S Tsutomu H Gen Y Young men with high normal blood pressure have lower serum adiponectin, smaller LDL, size and higher elevated heart rate than those optimal blood pressure Diabetes Care 2002 25 971 12032101
- [21]Harris SB Caulfield LE Sugamori ME Whalen EA Henning B The epidemiology of diabetes in pregnant Native Canadians. A risk profile Diabetes Care 1997 20 9 1422 5 9283790
- [22]Tamas G Kerenyi Z Gestational diabetes: current aspects on pathogenesis and treatment Exp Clin Endocrinal Diabetes 2001 109 Suppl 2 S400 11 11460587
- [23]Ben-Haroush A Yogev Y Hod M Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetes Diabet Med 2004 21 2 103 13 14984444
- [24]Dornhorst A Rossi M Risk and prevention of type11 diabetes in women with gestational diabetes Diabetes Care 1998 21 Suppl 2 B43 9 9704226
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Behboudi-Gandevani, S., Amiri, M., Bidhendi Yarandi, R., & Ramezani Tehrani, F. (2019) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-019-0406-1 · Cited by 321 · see citing works
Al-Rifai, R. H., Abdo, N. M., Paulo, M. S., Saha, S., & Ahmed, L. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.668447 · Cited by 78 · see citing works
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Chen, L., Mayo, R., Chatry, A., & Hu, G. (2016) · Current Epidemiology Reports · doi:10.1007/s40471-016-0063-y · Cited by 52 · see citing works
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Dłuski, D. F., Ruszała, M., Rudziński, G., Pożarowska, K., Brzuszkiewicz, K., & Leszczyńska-Gorzelak, B. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192315804 · Cited by 41 · see citing works
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- Authors
- Al Mahroos, S., Nagalla, D. S., Yousif, W., & Sanad, H.
- Affiliations
- Department of Medicine, Salmaniya Medical Complex, Manama Kingdom of Bahrain
- Salmaniya Medical Complex (BH)
- Corresponding author
- Nagalla, Das S.
- Venue
- Annals of Saudi Medicine
- Published
- 2005-03
- Volume
- 25
- Issue
- 2
- Pages
- 129-133
- ISSN
- 0256-4947 (ISSN-L)
- 0975-4466
- PMC
- PMC6147961
- OpenAlex
- W2186417899
- Cited by
- 29
- References
- 2
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2016: 1 · 2014: 1 · 2013: 1
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Annals of Saudi Medicine (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- gestational diabetes mellitus, prenatal screening, glucose challenge test, oral glucose tolerance test, insulin resistance, HOMA-IR, birth weight, expatriates, maternal hyperglycemia
- MeSH terms
- Bahrain, Birth Weight, Female, Fetal Macrosomia, Glucose Tolerance Test, Humans, Insulin Resistance, Pregnancy, Prospective Studies, Diabetes, Gestational
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