The DOI matches its Crossref record; 13 of the 14 references it cites were found in a registry or an index.
A Clinicopathological Study of Fine Needle Aspirates of Lymph Nodes from Patients with Suspected Tubercular Lymphadenopathy: Analysis of 640 Cases from a Tertiary Health Care Centre in North India
Open accessAbstract
Introduction: Fine needle aspiration cytology (FNAC) of lymph nodes is an out-patient, simple and, quick, cost-effective procedure that helps in the diagnosis of tubercular lymphadenopathy. This technique has high sensitivity and specificity which in addition to the establishment of cytological diagnosis, also helps to perform ancillary tests like ZN staining for AFB Bacilli and GeneXpert MTB/RIF Assay. Aims: To study the clinical and cytopathological features of fine-needle aspirates of lymph nodes from patients with suspected tubercular lymphadenopathy along with the role of ZN staining And GeneXpert assay in diagnosis. Materials and Methods: In this study 1123 patients presenting with lymphadenitis presenting to the cytopathology lab for FNAC of lymph nodes between May 2018 to May 2021 were included. Out of 1123 patients presenting with lymphadenopathies, there were 640 cases of tuberculous lymphadenitis. The clinical and cytopathological findings of these 640 cases were analyzed. Results: Most cases of tubercular lymphadenopathy were of the adult age group (20-59 years) and showed a female predominance. The most commonly involved lymph node was the cervical group. The most common clinical feature observed was cough (68.5%). Among the four cytomorphological patterns observed, maximum cases showed epithelioid cell granuloma with necrosis. Ziehl- Neelsen staining showed overall AFB positivity of 40.3%. Smear showing necrosis without epithelioid cell granuloma showed maximum AFB positivity among the four patterns.GeneXpert MTB/RIF Assay showed an overall detection rate of 84%. Conclusion: FNAC is a simple, cost-effective, outpatient technique with high diagnostic accuracy in cases of tubercular lymphadenopathy which can be coupled by Ziehl Staining for Acid-fast bacilli and GeneXpert MTB/RIF Assay. However, in smear-negative cases, it poses a diagnostic dilemma, thus in a developing country like India with a high prevalence rate of tuberculosis, FNAC coupled with Z.N. staining and new molecular tests like GeneXpert MTB/RIF assay should be included in the first-line investigation in cases with tubercular lymphadenopathy. Key words: Tuberculosis, Fine Needle Aspirate Cytology(FNAC), Necrosis, Epithelioid cells, Cytopathological pattern, Ziehl–Neelsen Staining, GeneXpert Mycobacterium/Rifampicin(MTB/RIF) Assay
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Global tuberculosis report (2014)
Gabbasova, L. A., & Who, E. R. E. (2014) · Cited by 12,702
Denkinger, C. M., Schumacher, S. G., Boehme, C. C., Dendukuri, N., Pai, M., & Steingart, K. R. (2014) · European Respiratory Journal · doi:10.1183/09031936.00007814 · Cited by 527
Ligthelm, L. J., Nicol, M. P., Hoek, K. G. P., Jacobson, R., van Helden, P. D., Marais, B. J., Warren, R. M., & Wright, C. A. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.01310-11 · Cited by 123
Mittal, P., Handa, U., Mohan, H., & Gupta, V. (2011) · Diagnostic Cytopathology · doi:10.1002/dc.21472 · Cited by 80 · cited 1×
“However, it has variable sensitivity, ranging from 20% to 43% (5).”
BackgroundAssessment of possible tuberculous lymphadenopathy by PCR compared to non-molecular methods
Pahwa, R., Hedau, S., Jain, S., Jain, N., Arora, V. M., Kumar, N., & Das, B. C. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.45904-0 · Cited by 76
Singh, U. B., Pandey, P., Mehta, G., Bhatnagar, A. K., Mohan, A., Goyal, V., Ahuja, V., Ramachandran, R., Sachdeva, K. S., & Samantaray, J. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149258 · Cited by 68
Cervical tuberculous lymphadenitis: clinical profile and diagnostic modalities
Singh, U., Gautam, H., Agrawal, S., & Verma, S. (2018) · International Journal of Mycobacteriology · doi:10.4103/ijmy.ijmy_99_18 · Cited by 67
Prevalence of tuberculous lymphadenitis in Gondar University Hospital, Northwest Ethiopia
Muluye, D., Biadgo, B., Woldegerima, E., & Ambachew, A. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-435 · Cited by 43
Khan, R. A., Wahab, S., Chana, R., Naseem, S. N., & Siddique, S. (2008) · Jornal de Pediatria · doi:10.2223/jped.1840 · Cited by 43
Lakhey, M., Bhatta, C. P., & Mishra, S. K. (2009) · Journal of Nepal Medical Association · doi:10.31729/jnma.188 · Cited by 18
EVALUATION OF GRANULOMATOUS LYMPHADENITIS ON FINE NEEDLE ASPIRATION CYTOLOGY - DIAGNOSTIC DILEMMA
Archana, B., Angali, V., Vimal, S. S., Sushama, K., Vijay, S., & Patil, D. Y. (2012) · Cited by 13
Diagnostic Accuracy of Fine Needle Aspiration Cytology in Diagnosis of Tuberculous Lymphadenitis
Nur, T.-E., Shirin, A., & Saha, M. M. (2019) · Journal of Enam Medical College · doi:10.3329/jemc.v9i1.39901 · Cited by 13
Associate Professor, D. O. P., Vimal, D. S., Dharwadkar, D. A., Associate Professor, D. O. P., S Chandanwale, D. S., Professor, D. O. P., Verma, D. V., Consultant, P. H., Khandelwal, D. A., & Post graduate student, D. O. P. (2016) · International Journal of Medical Research and Review · doi:10.17511/ijmrr.2016.i08.30 · Cited by 11 · cited 2×
“The diagnosis of tubercular lymphadenopathy can be made by fineneedle aspiration cytology combined with staining for acid-fast bacilli and newer methods like PCR- based amplification of mycobacterium DNA (3).”
Method
Flagged first, then by citations
1 of the 14 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- [6]6. Lawn SD, Nicol MP. Xpert(R) MTB/RIF assay: development, evaluation, and implementation of a new rapid molecular diagnostic for tuberculosis and rifampicin resistance. Future Microbiol. 2011;6:1067- 1082.
- [9]9. H. Jasim et al.Tuberculous lymphadenitis in Baghdad city: A review of 188 cases international Journal of Surgery Open 16 (2019) 40-47.
- [14]14. Chand, Dogra R. Chauhan N. Cytopathological Pattern of Tubercular Lymphadenopathy on FNAC: Analysis of 550 Consecutive Cases. J Clin Diagn Res.2014; 8(9): 16-19.
- [15]15. Balaji J. Sundaram SS, Rathinam SN Fine needle aspiration cytology in childhood TB lymphadenitis. Indian J Pediatr. 2009 Dec;76(12):1241-6.
Cited by
Sorted by citations
Chand, V., Katara, A., Chand, S., Vishwakarma, S., Chaudhry, V., & Chandra, H. (2025) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2025.108125 · Cited by 2
Pretracheal tuberculous lymph node: an uncommon differential of a midline neck swelling
Nagi, K., Lakshmanan, J., & Saxena, S. K. (2022) · BMJ Case Reports · doi:10.1136/bcr-2022-249894
Metadata
- Authors
- Ahmed, S., Ansari, H. A., & Fatima, N.
- Affiliations
- Aligarh Muslim University (IN)
- Venue
- International Journal of Health Sciences and Research
- Published
- 2022-01-20
- Volume
- 12
- Issue
- 1
- Pages
- 201-208
- ISSN
- 2249-9571 (ISSN-L)
- OpenAlex
- W4206899883
- Cited by
- 3
- References
- 14
- Citations by year
- 2025: 1 · 2022: 2
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Health Sciences and Research (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphadenopathy Diagnosis and Analysis
- Health Sciences › Medicine › Infectious Diseases › Diagnosis and treatment of tuberculosis
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Keywords
- fine needle aspiration cytology, lymph node cytology, Ziehl-Neelsen staining, Xpert MTB/RIF, acid-fast bacilli, epithelioid granulomas, smear-negative tuberculosis, tuberculosis diagnosis, lymphadenitis, cervical lymph nodes, molecular tuberculosis diagnosis, North India
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
