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Anti-Aging Effects Of Retinol And Alpha Hydroxy Acid On Elastin Fibers Of Artificially Photo-Aged Human Dermal Fibroblast Cell Lines
Open accessAbstract
Skin aging is a slow multifactorial process influenced by both internal as well as external factors. Ultra-violet radiations (UV), diet, smoking and personal habits are the most common environmental factors that affect skin aging. Fat contents and fibrous proteins as collagen and elastin are core internal structural components. The direct influence of UV on elastin integrity and health is central on aging of skin especially by time. The deposition of abnormal elastic material is a major marker in a photo-aged skin. Searching for compounds that may protect against cutaneous photodamage is exceedingly valued. Retinoids and alpha hydroxy acids have been endorsed by some researchers as possible candidates for protecting and or repairing the effect of UV damaged skin. For consolidating a better system of anti- and protective effects of such anti-aging agents, we evaluated the combinatory effects of various dosages of lactic acid and retinol on the dermal fibroblast’s elastin levels exposed to UV. The UV exposed cells showed significant reduction in the elastin levels. A combination of drugs with a higher concentration of lactic acid (30 -35 mM) and a lower concentration of retinol (10-15mg/mL) showed to work better in maintaining elastin concentration in UV exposed cells. We assume this preservation could be the result of increased tropo-elastin gene expression stimulated by retinol whereas lactic acid probably repaired the UV irradiated damage by enhancing the amount and integrity of the elastin fibers.
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“It is proposed to increase elastin protein levels and elastin fibres density in cultured dermal fibroblasts [17].”
From Elastin structure and its involvement in skin photoageing (2017) · cites this paper as [17]
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“Moreover, it is known that rays from sunlight account for the majority of the symptoms of premature skin ageing so the simple fact of using products that prevent sun exposure and its effects already indicate that it is a way to avoid skin photoageing [17].”
From Elastin structure and its involvement in skin photoageing (2017) · cites this paper as [17]
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Research works printed but not linked: 7
- A. Hayashi, T. Suzuki, and S. Tajima, "Modulations of elastin expression and cell proliferation by retinoids in cultured vascular smooth muscle cells," J. Biochem., vol. 117, pp. 132-136G. Jan 1995.
- J. William, B. Timothy, "Diseases of the Skin: clinical Dermatology", Saunders Elsevier. ISBN 0-7216-2921-0, 2006.
- L. D. Muiznieks, A. S. Weiss and F.W. Keeley, "Structural disorder and dynamics of elastin", Biochem Cell Biol 88 (2): 239-50, 2010.
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Cited by
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Elastin structure and its involvement in skin photoageing
Weihermann, A. C., Lorencini, M., Brohem, C. A., & de Carvalho, C. M. (2017) · International Journal of Cosmetic Science · doi:10.1111/ics.12372 · Cited by 195
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Ahmed, I. A., Mikail, M. A., Zamakshshari, N. H., & Abdullah, A.-S. H. (2020) · Biogerontology · doi:10.1007/s10522-020-09865-z · Cited by 188
Xiao, Y., Zhou, L. Y., Hao, H., Bao, Y., Yin, Q., & Xie, C. (2021) · Crystal Growth & Design · doi:10.1021/acs.cgd.0c01519 · Cited by 61
Zhong, J., Zhao, N., Song, Q., Du, Z., & Shu, P. (2024) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16415 · Cited by 65
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Metadata
- Authors
- Jarrar, M., Behl, S., Shaheen, N., Fatima, A., & Nasab, R.
- ORCID
- Venue
- Zenodo
- Publisher
- Zenodo
- Published
- 2015-03-05
- OpenAlex
- W1513798627
- Cited by
- 5
- References
- 0
- Citations by year
- 2024: 1 · 2021: 2 · 2020: 1 · 2016: 1
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- Locations
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by)
- Zenodo (CERN European Organization for Nuclear Research) (cc-by)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- skin aging, photoaging, retinol, α-hydroxy acids, lactic acid, elastin, dermal fibroblasts, ultraviolet radiation, combination therapy, anti-aging agents
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- CoChat. (2026). Citation check: Anti-Aging Effects Of Retinol And Alpha Hydroxy Acid On Elastin Fibers Of Artificially Photo-Aged Human Dermal Fibroblast Cell Lines. https://app.cochat.ai/papers/10.5281/zenodo.1100101
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- Jarrar, M., Behl, S., Shaheen, N., Fatima, A., & Nasab, R. (2015). Anti-Aging Effects Of Retinol And Alpha Hydroxy Acid On Elastin Fibers Of Artificially Photo-Aged Human Dermal Fibroblast Cell Lines. Zenodo. https://doi.org/10.5281/zenodo.1100101
