Telomerase activity as a marker for differential diagnosis of pancreatic adenocarcinoma: A systematic review and meta-analysis
Open accessAbstract
Background: Studies evaluating the role of telomerase activity in pancreatic adenocarcinoma are inconsistent and a systemic review of the available literature may shed new light on this issue. Objective: To systematically review the usefulness of telomerase activity in distinguishing pancreatic cancer from other pancreatic diseases. Methods: A comprehensive search of the PubMed and Embase databases was conducted to identify eligible studies. Only studies evaluating telomerase activity in patients with suspected or previously diagnosed pancreatic adenocarcinomas versus nonpancreatic adenocarcinomas and published in English with a sufficient number of cases were included. The hierarchical summary receiver operating characteristic (HSROC) model was used to establish the potential value of telomerase activity in the diagnosis of pancreatic adenocarcinoma. Results: A total of 19 studies qualified for this meta-analysis. In distinguishing pancreatic adenocarcinoma from benign diseases, the pooled sensitivity and specificity of telomerase activity were 0.81 (95% CI, 0.68-0.90) and 0.97 (95% CI, 0.93-0.98), respectively; the diagnostic odds ratio (DOR) was 126.62 (95% CI, 49.94-320.99); beta was −1.16 (95% CI, −3.62-1.29), Z was −0.93, p was 0.35>0.1, and lambda was 6.86 (95% CI, 1.01-12.70). In distinguishing pancreatic adenocarcinoma from chronic pancreatitis, the pooled sensitivity and specificity of telomerase activity were 0.77 (95% CI, 0.61-0.88) and 0.97 (95% CI, 0.91-0.99), respectively; DOR was 117.28 (95% CI, 32.25-426.53); beta was −0.38 (95% CI, −1.89-1.13), Z was −0.49, p was 0.62>0.1, and lambda was 5.30 (95% CI, 3.37-7.24). Conclusions: The present meta-analysis demonstrates that telomerase activity could be a useful biomarker for the differential diagnosis of pancreatic adenocarcinoma and benign pancreatic diseases.
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Telomerase activity in CRC has been detected in a significant percentage of tumor samples, ranging from 80% to 100%, highlighting its role as a pivotal step in CRC carcinogenesis.
“TA in CRC has been detected in a significant percentage of tumor samples, ranging from 80% to 100% [201], highlighting its role as a pivotal step in CRC carcinogenesis [202].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [202]
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Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy
Nikolouzakis, T. K., Chrysos, E., Docea, A. O., Fragkiadaki, P., Souglakos, J., Tsiaoussis, J., & Tsatsakis, A. (2024) · Cancers · doi:10.3390/cancers16111995 · Cited by 37 · see citing works
- Authors
- Gu, H., Xin, X., Pan, Y., Zhang, H., Tian, S., & Sun, C.
- Affiliations
- Guiyang Medical University (CN)
- Wuhan Union Hospital (CN)
- Corresponding author
- Sun, Chengyi
- Venue
- The International Journal of Biological Markers
- Publisher
- SAGE Publications
- Published
- 2016-04
- Volume
- 31
- Issue
- 2
- Pages
- 126-137
- ISSN
- 0393-6155 (ISSN-L)
- 1724-6008
- OpenAlex
- W2244153511
- Cited by
- 5
- References
- 64
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2020: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Locations
- The International Journal of Biological Markers (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Keywords
- pancreatic ductal adenocarcinoma, differential diagnosis, diagnostic biomarkers, chronic pancreatitis, sensitivity and specificity, diagnostic accuracy, pancreatic diseases, tumor markers, diagnostic odds ratio, pancreatic cancer diagnosis, benign pancreatic disease, prognosis, recurrence, metastasis, protein expression, telomerase reverse transcriptase
- MeSH terms
- Adenocarcinoma, Diagnosis, Differential, Humans, Pancreatic Neoplasms, Telomerase
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