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Exercise in Huntington’s Disease: Current State and Clinical Significance
Open accessAbstract
Background: Huntington’s disease (HD) is a rare, progressive neurodegenerative disease. Currently, there is no cure for the disease, but treatment may alleviate HD symptoms. In recent years, several exercise training interventions have been conducted in HD patients. In the current article, we review previous studies investigating targeted exercise training interventions in HD patients. Methods: We performed a literature search using the PubMed, Scopus, Web of Science, and Google Scholar databases on exercise training interventions in HD patients. Six publications fulfilled the criteria and were included in the review. Results: Exercise training resulted in beneficial effects on cardiovascular and mitochondrial function. Training effects on cognition, motor function, and body composition were less congruent, but a positive effect seems likely. Health-related quality of life during the training interventions was stable. Most studies reported no related adverse events in response to training. Discussion: Exercise training seems to be safe and feasible in HD patients. However, current knowledge is mainly based on short, small-scale studies and it cannot be transferred to all HD patients. Therefore, longer-term interventions with larger HD patient cohorts are necessary to draw firm conclusions about the potentially positive effects of exercise training in HD patients.
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“These beneficial changes underscore the importance of exercise in preventing and slowing the progression of ageing as well as neurodegenerative diseases.504–508”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [507]
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- Cubo, E, Rivadeneyra, J, Gil-Polo, C, Armesto, D, Mateos, A and Mariscal-Pérez, N (2015). Body composition analysis as an indirect marker of skeletal muscle mass in Huntington’s disease J Neurol Sci 358: 335–338, DOI: https://doi.org/10.1016/j.jns.2015.09.351 [PubMed] · DOI
- Pratley, RE, Salbe, AD, Ravussin, E and Caviness, JN (2000). Higher sedentary energy expenditure in patients with Huntington’s disease Ann Neurol 47: 64–70, DOI: https://doi.org/10.1002/1531-8249(200001)47:1<64::AID-ANA11>3.0.CO;2-S [PubMed] · doi:10.1002/1531-8249(200001)47:1
- Hart, EP Marinus, J Burgunder, JM Bentivoglio, AR Craufurd, D Reilmann, R et al. (2013). Better global and cognitive functioning in choreatic versus hypokinetic-rigid Huntington’s disease Mov Disord 28: 1142–1145, DOI: https://doi.org/10.1002/mds.25422 [PubMed] · DOI
- Read, J, Jones, R and Owen, G (2013). Quality of life in Huntington’s disease: a comparative study investigating the impact for those with pre-manifest and early manifest disease, and their partners J Huntingtons Dis 2: 159–175. [PubMed]
- Boileau, NR Stout, JC Paulsen, JS Cella, D McCormack, MK Nance, MA et al. (2017). Reliability and validity of the HD-PRO-TriadTM, a health-related quality of life measure designed to assess the symptom triad of Huntington’s disease J Huntingtons Dis 6: 201–215, DOI: https://doi.org/10.3233/JHD-170238 [PubMed] · DOI
- (self.__next_s=self.__next_s||[]).push([0,{"children":"window.__ENV__ = {\"RECAPTCHA_SITE_KEY\":\"6Le0hRwlAAAAAITIRbvt3u-Wt6RC5wmUUb_jefX3\",\"SERVICE_CODE\":\"up-j-tohm\",\"FRONTEND_URL\":\"https://tremorjournal.org\",\"FRONTEND_DOMAIN\":\"tremorjournal.org\",\"OJS_API_URL\":\"https://api.account.up-j-tohm.ubiquityjournal.website/api/journal/1\"};","id":"public-env"}])This page is for printing. If you wish to read this article, please visit its full version.Exercise in Huntington’s Disease: Current State and Clinical SignificanceSandro Manuel MuellerJens A. PetersenHans H. JungAbstractBackground: Huntington’s disease (HD) is a rare, progressive neurodegenerative disease. Currently, there is no cure for the disease, but treatment may alleviate HD symptoms. In recent years, several exercise training interventions have been conducted in HD patients. In the current article, we review previous studies investigating targeted exercise training interventions in HD patients.Methods: We performed a literature search using the PubMed, Scopus, Web of Science, and Google Scholar databases on exercise training interventions in HD patients. Six publications fulfilled the criteria and were included in the review.Results: Exercise training resulted in beneficial effects on cardiovascular and mitochondrial function. Training effects on cognition, motor function, and body composition were less congruent, but a positive effect seems likely. Health-related quality of life during the training interventions was stable. Most studies reported no related adverse events in response to training.Discussion: Exercise training seems to be safe and feasible in HD patients. However, current knowledge is mainly based on short, small-scale studies and it cannot be transferred to all HD patients. Therefore, longer-term interventions with larger HD patient cohorts are necessary to draw firm conclusions about the potentially positive effects of exercise training in HD patients.Year: 2019Volume 9Page/Article: 601DOI: 10.5334/tohm.515Accepted on Jan 2, 2019Published on Feb 4, 2019Peer ReviewedCC BY-NC-ND 3.0 · DOI
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Metadata
- Authors
- Mueller, S. M., Petersen, J. A., & Jung, H. H.
- Affiliations
- University Hospital Zurich (CH)
- Corresponding author
- Jung, Hans H.
- ORCID
- Petersen, Jens A.
- Venue
- Tremor and Other Hyperkinetic Movements
- Publisher
- Ubiquity Press, Ltd.
- Published
- 2019-02-04
- Volume
- 9
- Issue
- 0
- Pages
- 601
- ISSN
- 2160-8288 (ISSN-L)
- OpenAlex
- W4237937685
- Cited by
- 40
- References
- 0
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 4
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- creativecommons.org/licenses/by/4.0 (vor)
- Locations
- Tremor and Other Hyperkinetic Movements (publishedVersion, cc-by-nc-nd)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Columbia Academic Commons (Columbia University)
- Funders
- National Science Foundation
- Jacques und Gloria Gossweiler-Stiftung
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (135539)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- Huntington's disease, exercise training, neurodegenerative diseases, cardiovascular function, mitochondrial function, cognition, motor function, body composition, health-related quality of life, exercise safety, feasibility
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