The DOI matches its Crossref record; 2 of the 53 references it cites were found in a registry or an index, and 51 are not checked yet.
Exercise in Huntington’s Disease: Current State and Clinical Significance
Open accessAbstract
Background: Huntington’s disease (HD) is a rare, progressive neurodegenerative disease. Currently, there is no cure for the disease, but treatment may alleviate HD symptoms. In recent years, several exercise training interventions have been conducted in HD patients. In the current article, we review previous studies investigating targeted exercise training interventions in HD patients. Methods: We performed a literature search using the PubMed, Scopus, Web of Science, and Google Scholar databases on exercise training interventions in HD patients. Six publications fulfilled the criteria and were included in the review. Results: Exercise training resulted in beneficial effects on cardiovascular and mitochondrial function. Training effects on cognition, motor function, and body composition were less congruent, but a positive effect seems likely. Health-related quality of life during the training interventions was stable. Most studies reported no related adverse events in response to training. Discussion: Exercise training seems to be safe and feasible in HD patients. However, current knowledge is mainly based on short, small-scale studies and it cannot be transferred to all HD patients. Therefore, longer-term interventions with larger HD patient cohorts are necessary to draw firm conclusions about the potentially positive effects of exercise training in HD patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These beneficial changes underscore the importance of exercise in preventing and slowing the progression of ageing as well as neurodegenerative diseases.504–508”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [507]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The publisher hasn’t deposited this paper’s reference list.
Research works printed but not linked: 10
- Lavers, A (1981). An account of a weekly activity group with Huntington’s chorea patients on a ling stay ward Occup Ther 44: 387–392, DOI: https://doi.org/10.1177/030802268104401209 · DOI
- Ciancarelli, I, Tozzi Ciancarelli, MG and Carolei, A (2013). Effectiveness of intensive neurorehabilitation in patients with Huntington’s disease Eur J Phys Rehabil Med 49: 189–195. [PubMed]
- Ciancarelli, I De Amicis, D Di Massimo, C Sandrini, G Pistarini, C Carolei, A et al. (2015). Influence of intensive multifunctional neurorehabilitation on neuronal oxidative damage in patients with Huntington’s disease Funct Neurol 30: 47–52. [PubMed]
- Lodi, R Schapira, AH Manners, D Styles, P Wood, NW Taylor, DJ et al. (2000). Abnormal in vivo skeletal muscle energy metabolism in Huntington's disease and dentatorubropallidoluysian atrophy Ann Neurol 48: 72–76, DOI: https://doi.org/10.1002/1531-8249(200007)48:1<72::AID-ANA11>3.0.CO;2-I [PubMed] · doi:10.1002/1531-8249(200007)48:1
- Cubo, E, Rivadeneyra, J, Gil-Polo, C, Armesto, D, Mateos, A and Mariscal-Pérez, N (2015). Body composition analysis as an indirect marker of skeletal muscle mass in Huntington’s disease J Neurol Sci 358: 335–338, DOI: https://doi.org/10.1016/j.jns.2015.09.351 [PubMed] · DOI
- Pratley, RE, Salbe, AD, Ravussin, E and Caviness, JN (2000). Higher sedentary energy expenditure in patients with Huntington’s disease Ann Neurol 47: 64–70, DOI: https://doi.org/10.1002/1531-8249(200001)47:1<64::AID-ANA11>3.0.CO;2-S [PubMed] · doi:10.1002/1531-8249(200001)47:1
- Hart, EP Marinus, J Burgunder, JM Bentivoglio, AR Craufurd, D Reilmann, R et al. (2013). Better global and cognitive functioning in choreatic versus hypokinetic-rigid Huntington’s disease Mov Disord 28: 1142–1145, DOI: https://doi.org/10.1002/mds.25422 [PubMed] · DOI
- Read, J, Jones, R and Owen, G (2013). Quality of life in Huntington’s disease: a comparative study investigating the impact for those with pre-manifest and early manifest disease, and their partners J Huntingtons Dis 2: 159–175. [PubMed]
- Boileau, NR Stout, JC Paulsen, JS Cella, D McCormack, MK Nance, MA et al. (2017). Reliability and validity of the HD-PRO-TriadTM, a health-related quality of life measure designed to assess the symptom triad of Huntington’s disease J Huntingtons Dis 6: 201–215, DOI: https://doi.org/10.3233/JHD-170238 [PubMed] · DOI
- (self.__next_s=self.__next_s||[]).push([0,{"children":"window.__ENV__ = {\"RECAPTCHA_SITE_KEY\":\"6Le0hRwlAAAAAITIRbvt3u-Wt6RC5wmUUb_jefX3\",\"SERVICE_CODE\":\"up-j-tohm\",\"FRONTEND_URL\":\"https://tremorjournal.org\",\"FRONTEND_DOMAIN\":\"tremorjournal.org\",\"OJS_API_URL\":\"https://api.account.up-j-tohm.ubiquityjournal.website/api/journal/1\"};","id":"public-env"}])This page is for printing. If you wish to read this article, please visit its full version.Exercise in Huntington’s Disease: Current State and Clinical SignificanceSandro Manuel MuellerJens A. PetersenHans H. JungAbstractBackground: Huntington’s disease (HD) is a rare, progressive neurodegenerative disease. Currently, there is no cure for the disease, but treatment may alleviate HD symptoms. In recent years, several exercise training interventions have been conducted in HD patients. In the current article, we review previous studies investigating targeted exercise training interventions in HD patients.Methods: We performed a literature search using the PubMed, Scopus, Web of Science, and Google Scholar databases on exercise training interventions in HD patients. Six publications fulfilled the criteria and were included in the review.Results: Exercise training resulted in beneficial effects on cardiovascular and mitochondrial function. Training effects on cognition, motor function, and body composition were less congruent, but a positive effect seems likely. Health-related quality of life during the training interventions was stable. Most studies reported no related adverse events in response to training.Discussion: Exercise training seems to be safe and feasible in HD patients. However, current knowledge is mainly based on short, small-scale studies and it cannot be transferred to all HD patients. Therefore, longer-term interventions with larger HD patient cohorts are necessary to draw firm conclusions about the potentially positive effects of exercise training in HD patients.Year: 2019Volume 9Page/Article: 601DOI: 10.5334/tohm.515Accepted on Jan 2, 2019Published on Feb 4, 2019Peer ReviewedCC BY-NC-ND 3.0 · DOI
Cited by
Physical Activity and Brain Health
Di Liegro, C. M., Schiera, G., Proia, P., & Di Liegro, I. (2019) · Genes · doi:10.3390/genes10090720 · Cited by 370
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165
The protective role of exercise against age-related neurodegeneration
Sujkowski, A. L., Hong, L., Wessells, R. J., & Todi, S. V. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101543 · Cited by 143
Steele, T. A., Louis, E. K. S., Videnović, A., & Auger, R. R. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01031-8 · Cited by 129
The neuroprotective potential of carotenoids in vitro and in vivo
Manochkumar, J., Doss, C. G. P., El-Seedi, H. R., Efferth, T., & Ramamoorthy, S. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153676 · Cited by 119
Metadata
- Authors
- Mueller, S. M., Petersen, J. A., & Jung, H. H.
- Affiliations
- University Hospital Zurich (CH)
- Corresponding author
- Jung, Hans H.
- ORCID
- Petersen, Jens A.
- Venue
- Tremor and Other Hyperkinetic Movements
- Publisher
- Ubiquity Press, Ltd.
- Published
- 2019-02-04
- Volume
- 9
- Issue
- 0
- Pages
- 601
- ISSN
- 2160-8288 (ISSN-L)
- OpenAlex
- W4237937685
- Cited by
- 40
- References
- 0
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 4
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- creativecommons.org/licenses/by/4.0 (vor)
- Locations
- Tremor and Other Hyperkinetic Movements (publishedVersion, cc-by-nc-nd)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Columbia Academic Commons (Columbia University)
- Funders
- National Science Foundation
- Jacques und Gloria Gossweiler-Stiftung
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (135539)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- Huntington's disease, exercise training, neurodegenerative diseases, cardiovascular function, mitochondrial function, cognition, motor function, body composition, health-related quality of life, exercise safety, feasibility
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
