Effect of soy protein-rich diet on renal function in young adults with insulin-dependent diabetes mellitus
Abstract
BACKGROUND: Diabetic nephropathy is the most frequent cause of end-stage renal disease in the Western world. Dietary intake, including protein amount and type, seems to affect the progression of renal disease. This pilot study tested the hypothesis that substituting soy protein for animal protein in the diets of diabetics would help correct glomerular hyperfiltration. METHODS: Twelve young adults (aged 29.9 +/- 2.4 years) with type 1 diabetes mellitus (duration of diabetes 15.1 +/- 2.3 years) and hyperfiltration (glomerular filtration rate, GFR > 120 ml/min/1.73 m2) completed a crossover, dietary intervention trial. After a four-week assessment of baseline characteristics and dietary habits, subjects were assigned to either a control or soy diet for eight weeks after which each subject was crossed over to the alternative diet for another eight-week period. RESULTS: Mean GFR was significantly reduced (p < 0.02) after eight weeks on the soy diet (143 +/- 7.4 ml/min/1.73 m2) compared with baseline (159 +/- 7.7 ml/min/ 1.73 m2) and control diets (161 +/- 10.0 ml/min/1.73 m2). Urinary excretion of the soy isoflavones was significantly higher (p < 0.01) at the end of the soy diet (genistein 1,014.6 +/- 274.1 nmol/h, daidzein 2,645.1 +/- 989.6 nmol/h) compared with baseline (genistein 53.7 +/- 31.1 nmol/h, daidzein 151.1 +/- 74.1 nmol/h) and control diets (genistein 41.1 +/- 13.3 nmol/h, daidzein 127.5 +/- 54.0 nmol/h). The soy diet significantly reduced total and LDL cholesterol by 7% and 9%, respectively. CONCLUSIONS: Implementation of a soy-based diet appears to reduce the GFR and total and LDL cholesterol of young adults with type 1 diabetes and glomerular hyperfiltration, thus affecting positively their clinical profile.
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A soy protein-rich diet was found to reduce glomerular hyperfiltration in a study of patients with type 1 diabetes with early stage nephropathy.
“A soy protein-rich diet was found to reduce glomerular hyperfiltration in a study of patients with type 1 diabetes with early stage nephropathy [98].”
From Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function (2020) · cites this paper as [98]
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- Authors
- Stephenson, T. J., Setchell, K. D. R., Kendall, C. W. C., Jenkins, D. J. A., Anderson, J. W., & Fanti, P.
- Affiliations
- University of Kentucky (US)
- Cincinnati Children's Hospital Medical Center (US)
- University of Toronto (CA)
- Venue
- Clinical Nephrology
- Publisher
- Dustri-Verlgag Dr. Karl Feistle
- Published
- 2005-07-01
- Volume
- 64
- Issue
- 07
- Pages
- 1-11
- ISSN
- 0301-0430 (ISSN-L)
- OpenAlex
- W2086504051
- Cited by
- 56
- References
- 0
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r21at000323-02)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK07778-02, T32DK007778)
- National Center for Complementary and Integrative Health (AT00323-01)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- soy protein, type 1 diabetes, diabetic nephropathy, glomerular hyperfiltration, glomerular filtration rate, dietary protein substitution, soy isoflavones, genistein, daidzein, LDL cholesterol, total cholesterol, renal function
- MeSH terms
- Adolescent, Adult, Analysis of Variance, Diabetes Mellitus, Type 1, Diabetic Nephropathies, Female, Glomerular Filtration Rate, Humans, Cholesterol, LDL, Male, Middle Aged, Pilot Projects, Radionuclide Imaging, Treatment Outcome, Cross-Over Studies, Soybean Proteins
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