Cited by 126Nerve injury and regenerationNerve Injury and RehabilitationReconstructive Surgery and Microvascular Techniques

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Nerve Conduits for Nerve Repair or Reconstruction

Deal, Nicole D., Griffin, Justin W., Hogan, MaCalus V.·2012·Journal of the American Academy of Orthopaedic Surgeons

DOI 10.5435/jaaos-20-02-063

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Abstract

Advances in treating peripheral nerve lesions have resulted from research in nerve regeneration and the use biomaterials as well as synthetic materials. When direct tensionless repair of peripheral nerve lesions is not possible, nerve conduits may be used to bridge digital sensory nerve gaps of ≤3 cm. Nerve autograft is the benchmark for larger, longer, mixed, or motor nerve defects. Biologic, autogenous conduits-typically veins or, rarely, arteries-have demonstrated their utility in nerve gaps <3 cm in length. Three types of bioabsorbable conduit have been approved by the US Food and Drug Administration, constructed of collagen, polyglycolic acid, or caprolactone. Caprolactone conduits have been found to be equivalent in results to autograft. Collagen conduits are next best, and polyglycolic acid conduits are functionally inferior. Further research and prospective, multicenter, large-scale trials are needed to help establish the role of synthetic, bioabsorbable conduits in peripheral nerve reconstruction.

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Authors: Deal, N. D., Griffin, J. W., & Hogan, M. V.
Affiliations: University of Virginia (US)
ORCID: Griffin, Justin W.
Hogan, MaCalus V.
Venue: Journal of the American Academy of Orthopaedic Surgeons
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-02
Volume: 20
Issue: 2
Pages: 63-68
ISSN: 1067-151X (ISSN-L)
DOI: 10.5435/jaaos-20-02-063
OpenAlex: W2313709378
Cited by: 126
References: 21
Citations by year: 2026: 7 · 2025: 7 · 2024: 10 · 2023: 8 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 13 · 2015: 9 · 2014: 21 · 2013: 9 · 2012: 3
FWCI: 5.51
Type: journal article
Language: en
Open access: closed
Locations: Journal of the American Academy of Orthopaedic Surgeons (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Surgery › Nerve Injury and Rehabilitation
Health Sciences › Medicine › Surgery › Reconstructive Surgery and Microvascular Techniques
Keywords: nerve conduits, peripheral nerve repair, peripheral nerve reconstruction, nerve regeneration, nerve autograft, peripheral nerve injury
MeSH terms: Animals, Biocompatible Materials, Caproates, Collagen, Humans, Lactones, Nerve Regeneration, Polyglycolic Acid, Plastic Surgery Procedures, Peripheral Nerve Injuries

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Nerve Conduits for Nerve Repair or Reconstruction

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