The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Nerve Conduits for Nerve Repair or Reconstruction
Abstract
Advances in treating peripheral nerve lesions have resulted from research in nerve regeneration and the use biomaterials as well as synthetic materials. When direct tensionless repair of peripheral nerve lesions is not possible, nerve conduits may be used to bridge digital sensory nerve gaps of ≤3 cm. Nerve autograft is the benchmark for larger, longer, mixed, or motor nerve defects. Biologic, autogenous conduits-typically veins or, rarely, arteries-have demonstrated their utility in nerve gaps <3 cm in length. Three types of bioabsorbable conduit have been approved by the US Food and Drug Administration, constructed of collagen, polyglycolic acid, or caprolactone. Caprolactone conduits have been found to be equivalent in results to autograft. Collagen conduits are next best, and polyglycolic acid conduits are functionally inferior. Further research and prospective, multicenter, large-scale trials are needed to help establish the role of synthetic, bioabsorbable conduits in peripheral nerve reconstruction.
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“Microchannel devices exploit the fact that fully transected nerves are capable of regenerating across up to centimeter-long gaps left between the nerve stumps (Deal et al., 2012).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Deal et al., 2012
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Cites
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Limitations of Conduits in Peripheral Nerve Repairs
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Grand, Z., Greer, K., Brutti, J. A., Ciesla, C. D., Rockwell, M., Shae, J., Rasmussen, J., & Frye, P. (2025) · Cureus · doi:10.7759/cureus.88733 · Cited by 1
Identification of proteins in fluid collected from nerve regeneration chambers
Ye, Y., Li, L., & Li, Q. (2014) · Archives of Biological Sciences · doi:10.2298/abs1403035y · Cited by 1
Surgical Treatment of Nerve Entrapment Syndromes
Gulati, A., Krashin, D. L., & Karl, H. W. (2016) · Springer eBooks · doi:10.1007/978-3-319-27482-9_10 · Cited by 1
Yano, T., Akita, K., Yamaguchi, K., & Sawaizumi, M. (2017) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000001188 · Cited by 1
Nerve Anastomosis-our Experience of Thirteen Cases
Haroon, K., Taher, T., Alam, S., Alamgir, A., Reza, M. A., & Hossain, S. S. (2019) · Bangladesh Journal of Neurosurgery · doi:10.3329/bjns.v9i1.42922 · Cited by 1
Collagen Biomaterials for Nerve Tissue Engineering
Eleftheriadou, D., & Phillips, J. B. (2022) · Reference series in biomedical engineering · doi:10.1007/978-3-030-21052-6_20 · Cited by 2
AlHamdi, A., Bukamal, Z., & Leung, B. C. S. (2014) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1
Cellular Therapies in Nerve Regeneration
Cwykiel, J. M., Tfaily, E. B., & Siemionow, M. (2014) · Springer eBooks · doi:10.1007/978-1-4471-6335-0_76
Liard, O., & Moyse, E. (2013) · InTech eBooks · doi:10.5772/55726
Peljovich, A. E., & Fishman, F. G. L. (2014) · Springer eBooks · doi:10.1007/978-1-4614-8758-6_25-1
Cirugía de reparación del plexo braquial del adulto
Durandeau, A., & Fabre, T. (2014) · EMC - Técnicas Quirúrgicas - Ortopedia y Traumatología · doi:10.1016/s2211-033x(14)69193-3
Management of extensive nerve gaps of more than 5 cm by vein graft in three cases
Singh, S. (2020) · International Surgery Journal · doi:10.18203/2349-2902.isj20202439
Peripheral nervous system responses to biomaterials
Murphy, R., Faroni, A., & Reid, A. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102967-1.00024-4
Management of Nerve Trauma in the Mangled Extremity
Hu, J., Bruce, J. G., & Moore, A. M. (2020) · Current Trauma Reports · doi:10.1007/s40719-020-00195-6
Collagen Biomaterials for Nerve Tissue Engineering
Eleftheriadou, D., & Phillips, J. B. (2020) · Springer eBooks · doi:10.1007/978-3-030-06217-0_20-1
The Role of Perineurial Glia in Peripheral Nerve Regeneration
Lewis, G. M. (2015) · doi:10.18130/v3gv9p
Peljovich, A. E., & Fishman, F. G. L. (2014) · Springer eBooks · doi:10.1007/978-1-4614-8515-5_25
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Komplexe Schnittverletzung der Hand im Kindesalter – Herausforderungen und Chancen
Kupczyk, E. K., Jakubietz, R. G., Paul, M. M., Schäfer, S., & Hölscher-Doht, S. (2024) · Handchirurgie · Mikrochirurgie · Plastische Chirurgie · doi:10.1055/a-2234-0049
Surgery (Techniques, Spasticity and Neuroplasticity)
Hobitsch, K. (2025) · Springer eBooks · doi:10.1007/978-3-032-03409-0_6
Optimal Treatment of Digital Nerve Injury
Alelyani, R. H., Maniya, M. T., Althobaiti, M., Aljuaid, A. S., Alfarej, Z. M., Shakoor, M., Almenhali, A. A., Alghamdi, T. Z., Althbaiti, M. A., Alshehri, M. A., et al. (2026) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000004599
Górecki, M., Wiertel-Krawczuk, A., Huber, J., & Czarnecki, P. (2026) · Issues of Rehabilitation Orthopaedics Neurophysiology and Sport Promotion – IRONS · doi:10.5114/irons/216354
The Role of Collagen in Peripheral Nerve Regeneration and Emerging Repair Strategies
Hoang, A., Gutama, B. W., Okundia, S., Guntaka, R., Johnson, J., Giannas, E. (., Gergoudis, F. R., Torres‐Guzman, R. A., Thayer, W. P., Lineweaver, W., et al. (2026) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000004785
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Metadata
- Authors
- Deal, N. D., Griffin, J. W., & Hogan, M. V.
- Affiliations
- University of Virginia (US)
- Venue
- Journal of the American Academy of Orthopaedic Surgeons
- Published
- 2012-02
- Volume
- 20
- Issue
- 2
- Pages
- 63-68
- ISSN
- 1067-151X (ISSN-L)
- OpenAlex
- W2313709378
- Cited by
- 126
- References
- 21
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 10 · 2023: 8 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 13 · 2015: 9 · 2014: 21 · 2013: 9 · 2012: 3
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Orthopaedic Surgeons (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Surgery › Nerve Injury and Rehabilitation
- Health Sciences › Medicine › Surgery › Reconstructive Surgery and Microvascular Techniques
- Keywords
- nerve conduits, peripheral nerve repair, peripheral nerve reconstruction, nerve regeneration, nerve autograft, peripheral nerve injury
- MeSH terms
- Animals, Biocompatible Materials, Caproates, Collagen, Humans, Lactones, Nerve Regeneration, Polyglycolic Acid, Plastic Surgery Procedures, Peripheral Nerve Injuries
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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