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Cited by 10Moringa oleifera research and applicationsPhytochemicals and Antioxidant ActivitiesMangiferin and Mango Extracts

Effect of geographical and agroclimatic location on phytocompounds and antioxidant activity of Moringa oleifera leaves

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Sukmawaty, Eka, Ahmad, Ahyar, Karim, Abdul, Dwyana, Zaraswati, Karim, Harningsih, Larekeng, Siti, Masriany, Masriany, Zulkarnain, Zulkarnain, Armita, Devi, Alir, Rahmat·2024·Journal of Advanced Biotechnology and Experimental Therapeutics
DOI 10.5455/jabet.2024.d48
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Abstract

Moringa oleifera is known has high phytochemical content and biological activity. Differences in geographic and agroclimate can influence the phytochemical content and bioactivity of plants. This study aims to analyze differences in phytochemical content, antioxidant and antibacterial activity of Moringa oleifera leaves obtained from two different environments. Phytochemical content was analyzed qualitatively and quantitatively, bioactivity analysis was carried out by testing antioxidant activity and testing antibacterial activity. Molecular docking predictions for the 3 dominant compounds in both samples as antioxidants was also carried out to Cytochrome c peroxidase. The research results showed that both samples from both locations contained alkaloids, terpenoids, steroids, tannins, saponins, phenols, flavonoids, coumarins, quinones and glycosides. The total phenol and flavonoid content, and antioxidant of sample M1 showed higher than sample M2. From the FTIR analysis, it was confirmed that there were OH, C=O, CO, aliphatic and aromatic carbons functional groups. The most dominant compound in sample M1 based on GC-MS analysis is Levoglucosan (13.6%), while the dominant compound found in sample M2 was 9,12,15-Octadecatrienoic acid, (Z,Z,Z) (16.38%). Molecular docking analysis exhibited that the compound on both sample have promising antioxidant and antibacteria activity. Based on the results, it was revealed that differences in geographical location and agro-climatic conditions influence the phytochemical and bioactivity in Moringa oleifera leaves. These results can be used as a reference in selecting sources of active compounds for pharmacological purposes.

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  • The higher total flavonoid content (TFC) and iron-reducing power (FRPA) in the extracts from the North Zone could reflect better-developed protective mechanisms in plants from this region, possibly related to the increased production of secondary metabolites in response to environmental stressors, such as varying temperatures and soil types.

    “Also, the higher total flavonoid content (TFC) and iron-reducing power (FRPA) in the extracts from the North Zone could reflect better-developed protective mechanisms in plants from this region, possibly related to the increased production of secondary metabolites in response to environmental stressors, such as varying temperatures and soil types [58].”

    From Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity (2024) · cites this paper as [58]

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Authors
Sukmawaty, E., Ahmad, A., Karim, A., Dwyana, Z., Karim, H., Larekeng, S., Masriany, M., Zulkarnain, Z., Armita, D., & Alir, R.
Affiliations
  • Universitas Islam Negeri Alauddin Makassar (ID)
  • Hasanuddin University (ID)
  • Akademi Farmasi Yamasi Makassar (ID)
ORCID
Venue
Journal of Advanced Biotechnology and Experimental Therapeutics
Publisher
ScopeMed
Published
2024
Volume
7
Issue
3
Pages
556
ISSN
2616-4760 (ISSN-L)
DOI
10.5455/jabet.2024.d48
OpenAlex
W4402732538
Cited by
10
References
0
Citations by year
2026: 6 · 2025: 3 · 2024: 1
FWCI
2.44
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Advanced Biotechnology and Experimental Therapeutics (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Moringa oleifera research and applications
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
Keywords
Moringa oleifera, leaves, geographical origin, agroclimatic conditions, phytochemical composition, antioxidant activity, antibacterial activity, total phenolic content, flavonoids, levoglucosan, octadecatrienoic acid, cytochrome c peroxidase, molecular docking, plant bioactivity

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