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Cited by 3Skin Protection and AgingAdvancements in Transdermal Drug Deliverymelanin and skin pigmentation

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Ameliorative effect of transfersome gel of kepok banana peel extract (Musa balbisiana) against photoaging in Wistar rat skin

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Mayangsari, Elly, Mustika, Arifa, Nurdiana, Nurdiana, Samad, Nozlena·2024·Open Veterinary Journal
DOI 10.5455/ovj.2024.v14.i8.28PMC PMC11415925
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Abstract

Background: Repeated acute exposure to UVB rays can cause photoaging. Musa balbisiana peel contains flavonoid compounds which act as antioxidants. But, the physicochemical of flavonoids are unstable, high molecular weight and easily oxidized, causing its use is still limited and transdermal delivery to be inefficient. Aim: To investigate the ameliorative effect of transfersome gel of Musa balbisiana peel against photoaging in Wistar rat skin. Methods: Transfersome gel was characterized by TEM. In vivo research was used to determine ameliorative effects of Musa balbisiana peel. The composition of transfersome consist of ethanol extracts of Musa balbisiana peel, SPC, and tween 80. The gel was applied three times a week for four weeks with a total UVB radiation dose of 840 mJ/cm2. To evaluate the repair mechanism by measuring the degree of wrinkles, epidermal thickening, dermal thinning, collagen fiber irregularity, matrix metalloproteinase 1 and TGF-β expression, MDA and TNFα levels. Results: TEM results show that gel transfersome Musa balbisiana peel has a round morphology with a diameter of ± 50 nm and no aggregation, which are defined as nanoparticles. Transfersome gel ameliorated degree of wrinkle, epidermal thickening, dermal thinning and irregularity of collagen fibers caused by UVB exposure, suppresses lipid peroxidation by decreasing MDA and TNFα level, also collagen imbalance by inhibiting MMP-1 expression and activating TGF-β expression, which were found statistically significantly different from non transfersome gel group. Conclusion: Transfersome gel of Musa balbisiana peel can act as an alternative medicine to ameliorate clinical photoaging due to exposure UVB.

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Crossref · 10.5455/ovj.2024.v14.i8.28

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Figures

Fig. 1. Characterization of gel transfersome M. balbisiana peel using a TEM HT7700. The scale bar is 50 μm. Yellow arrow : morphology of transfersome gel of M. balbisiana peel.
Fig. 1. Characterization of gel transfersome M. balbisiana peel using a TEM HT7700. The scale bar is 50 μm. Yellow arrow : morphology of transfersome gel of M. balbisiana peel.CC BY-NC · PubMed Central
Fig. 2. Effect of transfersome gel of M. balbisiana peel. (A) Wrinkle formation on rat skin exposed to UVB (red arrow), p value <. (B) Assessment of epidermal thickness with HE staining; microscope magnification 100×; scale bar is 50 μm. SC: stratum corneum; EP: epidermis; D: dermis; yellow arrow: epidermal thickness. Data are presented as mean ± SD (n = 5). Statistical analysis was done by oneway ANOVA followed by post hoc test analysis using the SPSS software. Data with notation (*) implied a significant difference (p < 0.05).
Fig. 2. Effect of transfersome gel of M. balbisiana peel. (A) Wrinkle formation on rat skin exposed to UVB (red arrow), p value <. (B) Assessment of epidermal thickness with HE staining; microscope magnification 100×; scale bar is 50 μm. SC: stratum corneum; EP: epidermis; D: dermis; yellow arrow: epidermal thickness. Data are presented as mean ± SD (n = 5). Statistical analysis was done by oneway ANOVA followed by post hoc test analysis using the SPSS software. Data with notation (*) implied a significant difference (p < 0.05).CC BY-NC · PubMed Central
Fig. 3. Effect of transfersome gel of M. balbisiana peel. (A) Assessment of dermal thickness with HE staining (yellow line). (B) Assessment of collagen density with Masson trichrome staining (red arrow); microscope magnification 40×; scale bar is 50 μm. Data are presented as mean ± SD (n = 5). Statistical analysis was done by oneway ANOVA followed by post hoc test analysis using the SPSS software. Data with notation (*) implied a significant difference (p < 0.05).
Fig. 3. Effect of transfersome gel of M. balbisiana peel. (A) Assessment of dermal thickness with HE staining (yellow line). (B) Assessment of collagen density with Masson trichrome staining (red arrow); microscope magnification 40×; scale bar is 50 μm. Data are presented as mean ± SD (n = 5). Statistical analysis was done by oneway ANOVA followed by post hoc test analysis using the SPSS software. Data with notation (*) implied a significant difference (p < 0.05).CC BY-NC · PubMed Central
Fig. 4. Effect of transfersome gel of M. balbisiana peel on MMP-1 expressions. Immunohistochemistry sections of MMP-1; microscope magnification 100×; scale bar is 50 μm; brown staining indicates positive cells (yellow arrow). Quantitative analysis of expression intensity was performed using ImageJ 1.53e software. Data are presented as mean ± SD (n = 5). Statistical analysis was done by oneway ANOVA followed by post hoc test analysis using the SPSS software. Data with notation (*) implied a significant difference (p < 0.05).
Fig. 4. Effect of transfersome gel of M. balbisiana peel on MMP-1 expressions. Immunohistochemistry sections of MMP-1; microscope magnification 100×; scale bar is 50 μm; brown staining indicates positive cells (yellow arrow). Quantitative analysis of expression intensity was performed using ImageJ 1.53e software. Data are presented as mean ± SD (n = 5). Statistical analysis was done by oneway ANOVA followed by post hoc test analysis using the SPSS software. Data with notation (*) implied a significant difference (p < 0.05).CC BY-NC · PubMed Central
Fig. 5. Effect of transfersome gel of M. balbisiana peel on TGF-β expressions. Immunohistochemistry sections of TGF-β; microscope magnification 100×; scale bar is 50 μm; brown staining indicates positive cells (red arrow). Quantitative analysis of expression intensity was performed by ImageJ 1.53e software. Data are presented as mean ± SD (n = 5). Statistical analysis was done by oneway ANOVA followed by post hoc test analysis using the SPSS software. Data with notation (*) implied a significant difference (p < 0.05).
Fig. 5. Effect of transfersome gel of M. balbisiana peel on TGF-β expressions. Immunohistochemistry sections of TGF-β; microscope magnification 100×; scale bar is 50 μm; brown staining indicates positive cells (red arrow). Quantitative analysis of expression intensity was performed by ImageJ 1.53e software. Data are presented as mean ± SD (n = 5). Statistical analysis was done by oneway ANOVA followed by post hoc test analysis using the SPSS software. Data with notation (*) implied a significant difference (p < 0.05).CC BY-NC · PubMed Central

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Citations

Cites

Research works printed but not linked: 8

  1. Cheng Y.C Li T.S Su H.L Lee P.C Wang H.D Transdermal delivery systems of natural products applied to skin therapy and care Molecules (Basel, Switzerland) 2020 25 21 5051 33143260 PMC7662758
  2. Khan A Bai H Khan A Bai Z Neferine prevents ultraviolet radiationinduced skin photoaging Exp. Ther. Med 2020 31 89 96 PMC7132255 32266014
  3. Mayangsari E Mustika A Nurdiana N Samad N.A Comparison of UVA vs UVB photoaging rat models in short-term exposure Med. Arch 2024 78 2 88 91 38566862 PMC10983087
  4. Rahmi D Purnomo D Films B.P Chodijah S Husaini A Microemulgel formulation of Kepok banana peel extract (Musa paradisiaca L) as an antioxidant J. Phys. Conf. Ser 2019 1402 055090
  5. Rajabi M Mousa S.A Lipid nanoparticles and their application in nanomedicine Curr. Pharma. Biotechnol 2016 17 8 662 672 27087491
  6. Respati R.A Yusharyahya S.N Wibawa L.P Widaty S The dermoscopic features of photoaging and its association with Sun Index Score in the coastal population at Cilincing, Jakarta: a cross-sectional study Clin. Cosmet. Investing. Dermatol 2022 15 939 946 PMC9148576 35642176
  7. Surini S Leonyza A Suh C.W Formulation and in vitro penetration study of recombinant human epidermal growth factor-loaded transfersomal Emulgel Adv. Pharm. Bull 2020 10 4 586 594 33072536 PMC7539322
  8. Zhang Z Zhu H Zheng Y Zhang L Wang X Luo Z Tang J Lin L Du Z Dong C The effects and mechanism of collagen peptide and elastin peptide on skin aging induced by D-galactose combined with ultraviolet radiation J. Photochem. Photobiol. Biol 2020 210 111964 32717457

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Metadata

Authors
Mayangsari, E., Mustika, A., Nurdiana, N., & Samad, N.
Affiliations
  • University of Brawijaya (ID)
  • Universitas Airlangga (ID)
  • Universiti Sains Malaysia (MY)
Corresponding author
Mustika, Arifa
ORCID
Venue
Open Veterinary Journal
Publisher
ScopeMed
Published
2024
Volume
14
Issue
8
Pages
1990
ISSN
  • 2218-6050 (ISSN-L)
  • 2226-4485
DOI
10.5455/ovj.2024.v14.i8.28
PMC
PMC11415925
OpenAlex
W4402333951
Cited by
2
References
1
Citations by year
2025: 1 · 2024: 1
FWCI
0.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Open Veterinary Journal (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Universiti Sains Malaysia
  • Universitas Brawijaya
  • Universitas Airlangga
  • Lembaga Pengelola Dana Pendidikan
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords
photoaging, kepok banana peel, Musa balbisiana, UV-B radiation, transdermal drug delivery, flavonoids, antioxidant activity, collagen degradation, MMP-1, TGF-beta, lipid peroxidation, wrinkles, epidermal thickening, dermal thinning, topical gel formulation
MeSH terms
Animals, Female, Gels, Plant Extracts, Skin, Ultraviolet Rays, Skin Aging, Rats, Wistar, Musa, Rats

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