The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Prostaglandin E Synthase, a Terminal Enzyme for Prostaglandin E2 Biosynthesis
Open accessAbstract
Biosynthesis of prostanoids is regulated by three sequential enzymatic steps, namely phospholipase A2 enzymes, cyclooxygenase (COX) enzymes, and various lineagespecific terminal prostanoid synthases. Prostaglandin E synthase (PGES), which isomerizes COX-derived PGH2 specifically to PGE2, occurs in multiple forms with distinct enzymatic properties, expressions, localizations and functions. Two of them are membrane-bound enzymes and have been designated as mPGES-1 and mPGES-2. mPGES-1 is a perinuclear protein that is markedly induced by proinflammatory stimuli, is down-regulated by antiinflammatory glucocorticoids, and is functionally coupled with COX-2 in marked preference to COX-1. Recent gene targeting studies of mPGES-1 have revealed that this enzyme represents a novel target for anti-inflammatory and anti-cancer drugs. mPGES-2 is synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme. This enzyme is rather constitutively expressed in various cells and tissues and is functionally coupled with both COX-1 and COX-2. Cytosolic PGES (cPGES) is constitutively expressed in a wide variety of cells and is functionally linked to COX-1 to promote immediate PGE2 production. This review highlights the latest understanding of the expression, regulation and functions of these three PGES enzymes.
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Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh-ishi, S., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003505200 · Cited by 964
Self-citationTanioka, T., Nakatani, Y., Semmyo, N., Murakami, M., & Kudo, I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003504200 · Cited by 708 · cited 3×
“, 2002), and cytosolic PGES (cPGES) (Tanioka et al., 2000).”
BackgroundSelf-citationLi, S., Wang, Y., Matsumura, K., Ballou, L. R., Morham, S. G., & Blatteis, C. M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01225-1 · Cited by 270
Saha, S., Engström, L., Mackerlova, L., Jakobsson, P.-J., & Blomqvist, A. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00872.2004 · Cited by 108
Cited by
Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target
Samuelsson, B., Morgenstern, R., & Jakobsson, P.-J. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.3.1 · Cited by 538
Candelario-Jalil, E., de Oliveira, A. C. P., Gräf, S., Bhatia, H. S., Hüll, M., Muñoz, E., & Fiebich, B. L. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-25 · Cited by 223
Gawda, A., Majka, G., Nowak, B., Śróttek, M., Walczewska, M., & Marcinkiewicz, J. (2018) · Inflammation Research · doi:10.1007/s00011-018-1165-4 · Cited by 71
Dalvi, S., Nguyen, H. H., On, N., Mitchell, R. W., Aukema, H. M., Miller, D. W., & Hatch, G. M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13117 · Cited by 37
Uribe, G., Villéger, R., Bressollier, P., Dillard, R. N., Worthley, D. L., Wang, T. C., Powell, D. W., Urdaci, M. C., & Pinchuk, I. V. (2018) · Cellular Microbiology · doi:10.1111/cmi.12871 · Cited by 28
Metadata
- Authors
- Kudo, I., & Murakami, M.
- Venue
- BMB Reports
- Published
- 2005-11-30
- Volume
- 38
- Issue
- 6
- Pages
- 633-638
- ISSN
- 1976-6696 (ISSN-L)
- OpenAlex
- W1996733510
- Cited by
- 165
- References
- 4
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- gold
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