The DOI matches its Crossref record; 99 of the 100 references it cites were found in a registry or an index.
Disease model organism for Parkinson disease: Drosophila melanogaster
Open accessAbstract
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by selective and progressive loss of dopaminergic neurons. Genetic and environmental risk factors are associated with this disease. The genetic factors are composed of approximately 20 genes, such as SNCA, parkin, PTEN-induced kinase1 (pink1), leucine-rich repeat kinase 2 (LRRK2), ATP13A2, MAPT, VPS35, and DJ-1, whereas the environmental factors consist of oxidative stress-induced toxins such as 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), rotenone, and paraquat. The analyses of their functions and mechanisms have provided important insights into the disease process, which has demonstrated that these factors cause oxidative damage and mitochondrial dysfunction. The most invaluable studies have been performed using disease model organisms, such as mice, fruit flies, and worms. Among them, Drosophila melanogaster has emerged as an excellent model organism to study both environmental and genetic factors and provide insights to the pathways relevant for PD pathogenesis, facilitating development of therapeutic strategies. In this review, we have focused on the fly model organism to summarize recent progress, including pathogenesis, neuroprotective compounds, and newer approaches. [BMB Reports 2019; 52(4): 250-258].
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Another study that used Drosophila melanogaster showed a significant reduction of dopaminergic neurons, compared with the control group, under hypergravity conditions in a similar way to human’s Parkinson’s disease (PD)98.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [98]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227
α-Synuclein Locus Triplication Causes Parkinson's Disease
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) · Science · doi:10.1126/science.1090278 · Cited by 4,383
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
Betarbet, R. S., Sherer, T., MacKenzie, G. M., Garcia‐Osuna, M., Panov, A. V., & Greenamyre, J. T. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,770
Mitochondrial membrane permeabilization in cell death
Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481
Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
Zimprich, A. A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M. J., Lincoln, S., Kachergus, J. M., Hulihan, M., Uitti, R. J., Calne, D. B., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.005 · Cited by 3,088
A Drosophila model of Parkinson's disease
Feany, M. Β., & Bender, W. W. (2000) · Nature · doi:10.1038/35006074 · Cited by 2,156
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788
Flagged first, then by citations
1 of the 100 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- 10.1038/nature04779 · DOI · Paper page
Cited by
Sorted by citations
Items 101–111 of 111
Beyond petri dish: small animal models bridge in vitro and in vivo antioxidant assays
Samarasinghe, H. G. A. S., & Santhiravel, S. (2025) · Journal of Food Bioactives · doi:10.26599/jfb.2025.95031420
Rouse, J. L., Corns, L. F., Seeley, A., & Freestone, N. (2025) · AJP Advances in Physiology Education · doi:10.1152/advan.00085.2025
Nunes, R. G. D. S., Lira, Y. V. D. S., Silva, J. R. D. L., Costa, A. R., de Menezes, I. R. A., Jales, F. L. M. D. L., dos Santos, C. A. L., Duarte, A. E., Barros, L. M., Dantas, T. D. S., et al. (2025) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2025.2605468
Samson, J. S., Rajagopal, K., & Parvathi, V. D. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153509
Interaction entre autophagie et exosomes au niveau synaptique dans la maladie de Parkinson
Sanchez-Mirasierra, I. (2023) · theses.fr (ABES) · doi:10.70675/7104d6d5z945ez494eza917zda9e6be1eea6
Khalupniak, Y., Tolstun, D. A., Koshel, N. M., Dubiley, T. A., & Serebrovska, Z. O. (2026) · Problems of ageing and longevity (Ukraine) · doi:10.71012/pro-ageing-2026-2-02
Eckert, F. B., Triches, F. F., Costa, J. E. M., Suman, P. R., Toni, D. C. D., & de Oliveira, C. L. (2026) · Alternatives to Laboratory Animals · doi:10.1177/02611929261468339
Chronic Paraquat Neurotoxicity and Dopaminergic Degeneration: A Mechanistic Review
Riaz, S., Ali, S., Summer, M., Iqbal, A., Ashraf, R., & Bibi, R. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.71676
Witte, C., Mitra, S., Lackey, K., Krishnan, N., & Chaudhuri, A. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116538
Natural products in the management of Parkinson's disease in animal models
Desouky, M. A., Abdelhamid, A. H., Gamal, N. K., Naeem, A. G., Sabry, N. C., Fahmy, S. M., Hanna, D. M. F., & Michel, H. E. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-54032-5.00010-3
Metadata
- Authors
- Aryal, B., & Lee, Y.
- Affiliations
- Kookmin University (KR)
- Venue
- BMB Reports
- Published
- 2019-04-30
- Volume
- 52
- Issue
- 4
- Pages
- 250-258
- ISSN
- 1976-6696 (ISSN-L)
- 1976-670X
- PMC
- PMC6507844
- OpenAlex
- W2942930317
- Cited by
- 111
- References
- 100
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 21 · 2023: 25 · 2022: 20 · 2021: 9 · 2020: 7 · 2019: 5
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- BMB Reports (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (NRF-2016R1D1A1B03931273, NRF-2018R1A2B6004202)
- Ministry of Education
- Kookmin University
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- Parkinson's disease, Drosophila melanogaster, dopaminergic neuron loss, neurodegeneration, genetic risk factors, environmental risk factors, oxidative stress, mitochondrial dysfunction, neuroprotective compounds, Parkin, LRRK2, MPTP, rotenone, paraquat, SNCA, PINK1, DJ-1, ATP13A2, MAPT, VPS35
- MeSH terms
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Protein Deglycase DJ-1, PTEN-Induced Putative Kinase, Adenosine Triphosphatases, Animals, Disease Models, Animal, Drosophila melanogaster, Humans, Membrane Proteins, Mitochondria, Parkinson Disease, Hazardous Substances, Protein Serine-Threonine Kinases, Oxidative Stress, Neurodegenerative Diseases, Drosophila Proteins, Vesicular Transport Proteins, Ubiquitin-Protein Ligases, alpha-Synuclein, Dopaminergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
