TMEM39A and Human Diseases: A Brief Review
Open accessAbstract
Transmembrane Protein 39A (TMEM39A) is a member of TMEM family. The understanding about this protein is still limited. The earlier studies indicated that TMEM39A was a key mediator of autoimmune disease. TMEM39A seems to be involved in systemic lupus erythematosus and multiple sclerosis in numerous of populations. All of these works stop at insufficient information by using gene functioning methods such as: Genome-wide association studies (GWASs) and/or follow-up study. It is the fact that the less understood of TMEM39A actually is the attraction to the scientist in near future. In this review the current knowledge about TMEM39A and its possible roles in cell biology, physiology and pathology will be described.
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Given TMEM39A's important contributions to inflammation, dysregulated type I interferon responses, and other immune processes which are also implicated in AD, methylation differences affecting this gene are particularly relevant.
“given its important contributions to inflammation, dysregulated type I interferon responses, and other immune processes [82] which are also implicated in AD, methylation differences affecting this gene are particularly relevant.”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [82]
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Additional file 2 of Sex-specific DNA methylation differences in Alzheimer’s disease pathology
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Additional file 1 of Sex-specific DNA methylation differences in Alzheimer’s disease pathology
Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Figshare · doi:10.6084/m9.figshare.14490461
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- Authors
- Tran, Q., Park, J., Lee, H., Hong, Y., Hong, S., Park, S., Park, J., & Kim, S.-H.
- Affiliations
- Chungnam National University (KR)
- Gachon University (KR)
- Department of Pharmacology and Medical Science, Metabolic Syndrome and Cell Signaling Laboratory, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, K
- Corresponding author
- Park, Jongsun
- Kim, Seon-Hwan
- Venue
- Toxicological Research
- Published
- 2017-07-15
- Volume
- 33
- Issue
- 3
- Pages
- 205-209
- ISSN
- 1976-8257 (ISSN-L)
- 2234-2753
- PMC
- PMC5523561
- OpenAlex
- W2734776877
- Cited by
- 25
- References
- 42
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 1 · 2019: 4 · 2018: 4
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Toxicological Research (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Chungnam National University(CNU)
- National Research Foundation of Korea(NRF) (NRF-2012M3A9B6055302, NRF-2014R1A1A3050752, NRF-2015R1A2A2A01003597, NRF-2015R1D1A3A01015694)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- autoimmune disease, systemic lupus erythematosus, multiple sclerosis, disease susceptibility, genome-wide association study
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