Effects of acute supplementation of panax ginseng on endurance performance in healthy adult males of Kolkata, India
Open accessAbstract
Background and Aim: Panax ginseng C. A. Meyer (PG), a worldwide renowned “adaptogen”, is believed to combat stress and augment endurance performance. Studies available regarding chronic supplementation of PG revealed contradictory findings. This study, for the first time, was conducted to examine the effects of acute supplementation of PG on endurance performance in healthy sedentary male university students of Kolkata, India. Methods: In this placebo controlled double blind study, effects of acute supplementation (1hr before endurance exercise) of 200 mg PG on endurance exercise was examined in healthy males (n=12), age ranging from 20 to 24 years. Endurance time, heart rate and rate of perceived exertion (RPE) were recorded. Blood samples were drawn just before supplementation and at the time of exhaustion for biochemical analysis of glucose, insulin, lactic acid, free fatty acid, lipid peroxidase, catalase, superoxide dismutase and total thiol. Data were analyzed by paired t-test, one-way ANOVA with post-hoc test. Results: Endurance time was significantly higher (p<0.001) in PG-trial (96.17±1.19 min) compared to placebo (PL) trial (92.42±1.24 min). Heart-rate and RPE at the time of exhaustion in PL-trial were significantly greater (p<0.05) than PG-trial. Post-exercise values of lactic acid, free fatty acid, lipid peroxidase were significantly greater (p<0.05) in placebo trial than PG trial while post-exercise values of glucose (78.96±1.67 mg/dl), insulin (3.13±0.56 μU/ml), catalase (78.02±1.38 μmol of H2O2/min/mg of protein), superoxide-dismutase (22.41±1.24 nmol/mg of protein) and total thiol (23.42±1.09 μmol/L) of PG-trial were significantly greater (p<0.05) than that of PL trial (75.33±1.5 mg/dl, 1.71±0.34 μU/ml, 75.84±0.92 μmol of H2O2/min/mg of protein, 19.36±1.45 nmol/mg of protein and 18.85±1.25 μmol/L respectively). Conclusion: Thus, acute supplementation of 200 mg PG has ergogenic effect in studied population.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The intake of Panax ginseng extract is not associated with serious side effects.
“The intake of Panax ginseng extract is not associated with serious side effects [21,32,33,34,35,36,37,38,39,40,41].”
From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Ellman, G. L. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90090-6 · Cited by 26,383 · see citing works
Marklund, S. L., & MARKLUND, G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03714.x · Cited by 10,382 · see citing works
THE COLORIMETRIC DETERMINATION OF LACTIC ACID IN BIOLOGICAL MATERIAL
Barker, S. B., & Summerson, W. H. (1941) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51379-x · Cited by 3,454 · see citing works
Power and Sample Size Calculations for Studies Involving Linear Regression
Dupont, W. D., & Plummer, W. D. (1998) · Controlled Clinical Trials · doi:10.1016/s0197-2456(98)00037-3 · Cited by 1,024 · see citing works
Rapid colorimetric determination of free fatty acids
Lowry, R. R., & Tinsley, I. J. (1976) · Journal of the American Oil Chemists Society · doi:10.1007/bf02636814 · Cited by 678 · see citing works
A simple and rapid colorimetric method for determination of free fatty acids for lipase assay
Kwon, D. Y., & Rhee, J. S. (1986) · Journal of the American Oil Chemists Society · doi:10.1007/bf02676129 · Cited by 377 · see citing works
Vuksan, V. V. V., Sung, M., Sievenpiper, J. L., Stavro, P. M., Jenkins, A. L., Buono, M. D., Lee, K.-S., Leiter, L. A., Nam, K. Y., Arnason, J. T., et al. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.04.003 · Cited by 287 · see citing works
Selected herbals and human exercise performance
Bucci, L. R. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.2.624s · Cited by 274 · see citing works
Tietz clinical guide to laboratory tests.
Wu, A. H. B. (2006) · Medical Entomology and Zoology · Cited by 240 · see citing works
Therapeutic Potential of Ginsenosides as an Adjuvant Treatment for Diabetes
Bai, L., Gao, J., Wei, F., Zhao, J., Wang, D., & Wei, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00423 · Cited by 229 · see citing works
Efficacy and safety of ginseng
Kitts, D., & Hu, C. (2000) · Public Health Nutrition · doi:10.1017/s1368980000000550 · Cited by 208 · see citing works
Sapin, R., Galudec, V. L., Gasser, F., Pinget, M., & Grucker, D. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.3.602 · Cited by 95 · see citing works
Effects of Panax ginseng extract on exercise-induced oxidative stress.
Kim, S. H., Park, K. S., Chang, M. J., & Sung, J. H. (2005) · PubMed · Cited by 77 · see citing works
Actoprotective effect of ginseng: improving mental and physical performance
Oliynyk, S., & Oh, S. (2013) · Journal of Ginseng Research · doi:10.5142/jgr.2013.37.144 · Cited by 64 · see citing works
Pieralisi, G., Ripari, P., & Vecchiet, L. (1991) · PubMed · Cited by 62 · see citing works
Engels, H. J., Said, J. M., & Wirth, J. C. (1996) · Nutrition Research · doi:10.1016/0271-5317(96)00138-8 · Cited by 33 · see citing works
Lee, E. S., Yang, Y. J., Lee, J. H., & Yoon, Y. S. (2017) · Journal of Ginseng Research · doi:10.1016/j.jgr.2017.03.001 · Cited by 29 · see citing works
Caldwell, L. K., DuPont, W. H., Beeler, M. K., Post, E. M., Barnhart, E. C., Hardesty, V. H., Anders, J. P. V., Borden, E. C., Volek, J. S., & Kraemer, W. J. (2018) · Europe PMC (PubMed Central) · Cited by 22 · see citing works
Lee, J., Jin, H. J., Park, J., Jung, S. K., Jang, J.-Y., & Park, H. (2012) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2012.4.2.110 · Cited by 21 · see citing works
Red ginseng as an ergogenic aid: A systematic review of clinical trials
Lee, S., Lee, N. H., & Jung, H. C. (2016) · Physical Activity and Nutrition · doi:10.20463/jenb.2016.12.20.4.2 · Cited by 3 · see citing works
Ginseng supplementation does not enhance healthy young adults' peak aerobic exercise performance
Allen, J. D. (1999) · Complementary Therapies in Medicine · doi:10.1016/s0965-2299(99)80016-8 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 23 references couldn’t be matched to a known paper.
Research works printed but not linked: 8
- Ping FWD, Keong CC, Bandyopadhyay A. Effects of acute supplementation of Panax ginseng on endurance running in a hot and humid environment. Ind J Med Res. 2011;133(1):96-102.
- Talbott SM. A guide to understanding dietary supplements in Philadelphia: Lip- pincott Williams and Wilkins. Haworth Press, New York. 1995.
- Cherdrungsi P, Rungreong K. Effect of standardized ginseng extract and exer- cise training on aerobic and anaerobic exercise capacities in human. J Ginseng Res. 1995;19(2):93-100.
- Forgo I, Schimert G. The duration of effect of the standardized ginseng extract G115 in healthy competitive athletes. Notabene Med. 1985;15:636-40.
- Claiborne A. Catalase activity. In: Greenwald RA. CRC Handbook of methods for oxygen radical research, 3 rd Ed. Florida: CRC Press. 1985;283-4.
- Wright JR, Colby HD, Miles PR. Cytosolic factors that affect microsomal lipid peroxidation in lung and liver. Arch Biochem Biophys. 1981;206(2):296-304.
- Reay JL, Scholey AB, Milne A, Fenwick J, Kennedy DO. Panax ginseng has no effects on indices of glucose regulation following acute and chronic ingestion in healthy volunteers. Br J Nutr. 2009;101(11):1673-8.
- Jung HL, Kwak HE, Kim SS, Kim YC, Lee CD, Byurn HK, et al. Effects of Panax ginseng supplementation on muscle damage and inflammation after uphill treadmill running in humans. Am J Clin Med. 2011;39(3):441-50.
Cited by
Sorted by citations
Plant Adaptogens—History and Future Perspectives
Todorova, V., Ivanov, K., Delattre, C., Nalbantova, V., Karcheva-Bahchevanska, D., & Ivanova, S. (2021) · Nutrients · doi:10.3390/nu13082861 · Cited by 121 · see citing works
Todorova, V., Ivanov, K., & Ivanova, S. (2021) · Plants · doi:10.3390/plants11010064 · Cited by 56 · see citing works
Khan, N., Sharma, S. R., Dahiya, I., Khan, J. A., Sharma, S. S., & Sharma, R. K. (2022) · Journal of Sports Sciences · doi:10.1080/02640414.2022.2162753 · Cited by 7 · see citing works
Adaptogens - use, history and future
Marciniak, A., Nemeczek, S., Walczak, K., Walczak, P., MERKISZ, K., Grzybowski, J., Grzywna, N., JASKUŁA, K., & ORŁOWSKI, W. (2023) · Quality in Sport · doi:10.12775/qs.2023.09.01.002 · Cited by 3 · see citing works
Traoré, M., Guenné, S., Kobendé, G. T., Daboné, A. A. A., Diao, M., Sama, H., Bonzi, J. Y., Coulibaly, G., Hilou, A., Stevigny, C., et al. (2026) · Transformative Medical Materials · doi:10.1016/j.trmm.2026.100019 · Cited by 1 · see citing works
Phytochemical Contain, Biological Properties and Toxicities of Herbals Used for DopingPreprint
Traoré, M., Guenné, S., Kobendé, G. T., Daboné, A. A. A., Diao, M., Sama, H., Bonzi, J. Y., Coulibaly, G., Hilou, A., & Kiendrébeogo, M. (2024) · Preprints.org · doi:10.20944/preprints202401.0223.v1 · Cited by 1 · see citing works
Adaptogens, Performance, and Psychophysiological Responses to Exercise: A Narrative Review
Schmid, D. G., Pitts, M. M., Sizemore, A. A., & Ballmann, C. G. (2026) · Journal of Phytomedicine · doi:10.3390/jphytomed1020010
- Authors
- Bhattacharjee, I., & Bandyopadhyay, A.
- Affiliations
- University of Calcutta (IN)
- ORCID
- Bandyopadhyay, Amit
- Venue
- International Journal of Clinical and Experimental Physiology
- Publisher
- Manuscript Technomedia LLP
- Published
- 2020-07-07
- Volume
- 7
- Issue
- 2
- Pages
- 63-68
- ISSN
- 2348-8093 (ISSN-L)
- 2348-8832
- OpenAlex
- W3041196513
- Cited by
- 8
- References
- 23
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- International Journal of Clinical and Experimental Physiology (publishedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
- Keywords
- Panax ginseng, acute supplementation, endurance performance, endurance exercise, adaptogens, oxidative stress, lipid peroxidation, antioxidant enzymes, superoxide dismutase, catalase, total thiol, lactic acid, free fatty acids, heart rate, rating of perceived exertion, sex differences in exercise response
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
