Different Distribution of Pentraxin 3 and C-Reactive Protein in Coronary Atherosclerotic Plaques
Open accessAbstract
AIM: To understand the differences between histopathological characteristics related to PTX3 (pentraxin 3) and CRP (C-reactive protein) in coronary atherosclerotic plaques. METHODS AND RESULTS: To assess the localization of PTX3 and CRP in coronary plaque, immunohistochemistry was performed using 157 coronary artery specimens from 45 autopsied cases. Overall, immunoreactivity to CRP was more intense than that to PTX3 in lipid rich plaque; however, PTX3 was notably abundant in areas of intraplaque hemorrhage, in which CRP was quite sparse. On quantitative analysis, complicated plaques showed more immunopositive area of PTX3 than fibroatheroma, but with CRP, this trend disappeared. In addition, we examined the phenotype of macrophages in PTX3- and CRP-rich areas using CD163 staining (M2 macrophages). Consequently, these areas were differently characterized by the accumulation of macrophages with high and low magnitude of CD163 positivity, respectively. Next, we immunohistochemically investigated relationships among PTX3, CRP, histological components and clinical presentation in 73 coronary atherectomy specimens obtained from 35 and 38 patients with unstable (UAP) and stable angina pectoris (SAP), respectively. Both PTX3 and CRP were more intense in culprit plaques from patients with UAP than with SAP, and they significantly correlated with CD68 (pan macrophage)-positive areas; however, there was no correlation between PTX3 and CRP. CONCLUSION: Although PTX3 and CRP were more enhanced in unstable than in stable coronary plaques, their distribution distinctly differed, suggesting that they play distinct biological roles in unstable plaques.
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In a study on the genotype related to CRP concentration in the blood and the frequency of CAD, there was no association between the concentration of CRP and the frequency of CAD.
“Conversely, in a study on the genotype related to CRP concentration in the blood and the frequency of CAD, there was no association between the concentration of CRP and the frequency of CAD282).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [282]
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Cites
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315 · see citing works
C-Reactive Protein Levels and Outcomes after Statin Therapy
Ridker, P. M., Cannon, C. P., Morrow, D., Rifai, N., Rose, L. M., McCabe, C. H., Pfeffer, M. A., & Braunwald, E. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042378 · Cited by 2,292 · see citing works
Inflammation in Atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.09.009 · Cited by 2,228 · see citing works
Stary, H. C., Chandler, A. B., Dinsmore, R. E., Fuster, V., Glagov, S. K., Insull, W., Rosenfeld, M. E., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.9.1512 · Cited by 959 · see citing works
Garlanda, C., Bottazzi, B., Bastone, A., & Mantovani, A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115756 · Cited by 885 · see citing works
Castell, J. V., Gómez-Lechón, M. J., David, M., Fabra, R., Trullenque, R., & Heinrich, P. C. (1990) · Hepatology · doi:10.1002/hep.1840120517 · Cited by 759 · see citing works
Stary, H. C., Chandler, A. B., Glagov, S. K., Guyton, J. R., Insull, W., Rosenfeld, M. E., Schaffer, S. A., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.5.840 · Cited by 738 · see citing works
Buckley, D., Fu, R. F., Freeman, M., Rogers, K. R., & Helfand, M. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-7-200910060-00009 · Cited by 557 · see citing works
Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3
Mantovani, A., Garlanda, C., Doni, A., & Bottazzi, B. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9126-7 · Cited by 440 · see citing works
Prognostic Significance of the Long Pentraxin PTX3 in Acute Myocardial Infarction
Latini, R., Maggioni, A. P., Peri, G., Gonzini, L., Lucci, D., Mocarelli, P., Vago, L., Pasqualini, F., Signorini, S. G., Soldateschi, D., et al. (2004) · Circulation · doi:10.1161/01.cir.0000145167.30987.2e · Cited by 431 · see citing works
Coronary Intraplaque Hemorrhage Evokes a Novel Atheroprotective Macrophage Phenotype
Boyle, J. J., Harrington, H. A., Piper, E., Elderfield, K., Stark, J., Landis, R. C., & Haskard, D. O. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080431 · Cited by 319 · see citing works
Production of the Long Pentraxin PTX3 in Advanced Atherosclerotic Plaques
Rolph, M. S., Zimmer, S., Bottazzi, B., et al. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000015595.95497.2f · Cited by 284 · see citing works
Deficiency of the Long Pentraxin PTX3 Promotes Vascular Inflammation and Atherosclerosis
Norata, G. D., Marchesi, P., Venu, V. K. P., Pasqualini, F., Anselmo, A., Moalli, F., Pizzitola, I., Garlanda, C., Mantovani, A., & Catapano, A. L. (2009) · Circulation · doi:10.1161/circulationaha.108.806547 · Cited by 276 · see citing works
Inoue, K., Sugiyama, A., Reid, P. C., Ito, Y., Miyauchi, K., Mukai, S., Sagara, M., Miyamoto, K., Satoh, H., Kohno, I., et al. (2007) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000252126.48375.d5 · Cited by 257 · see citing works
Self-citationCD163: a signal receptor scavenging haptoglobin–hemoglobin complexes from plasma
Graversen, J. H., Madsen, M. M., & Moestrup, S. K. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00144-3 · Cited by 245 · see citing works
Independent Prognostic Value of Elevated C-Reactive Protein in Unstable Angina
Ferreirós, E., Boissonnet, C. P., Pizarro, R., Merletti, P. G., Corrado, G., Cagide, A. M., & Bazzino, O. O. (1999) · Circulation · doi:10.1161/01.cir.100.19.1958 · Cited by 222 · see citing works
C-Reactive Protein as a Screening Test for Cardiovascular Risk in a Multiethnic Population
Anand, S. S., Razak, F. A., Yi, Q., Davis, B. C., Jacobs, R., Vuksan, V., Lonn, E., Teo, K. K., McQueen, M., & Yusuf, S. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000135845.95890.4e · Cited by 197 · see citing works
An Update on the Role of Markers of Inflammation in Atherosclerosis
Corrado, E., Rizzo, M., Coppola, G., Fattouch, K., Novo, G., Marturana, I., Ferrara, F., & Novo, S. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.2600 · Cited by 197 · see citing works
Expression of pentraxin 3 (PTX3) in human atherosclerotic lesions
Savchenko, A. F., Imamura, M., Ohashi, R., Jiang, S. S., Kawasaki, T., Hasegawa, G., Emura, I., Iwanari, H., Sagara, M., Tanaka, T., et al. (2008) · The Journal of Pathology · doi:10.1002/path.2314 · Cited by 194 · see citing works
Self-citationRole of the soluble pattern recognition receptor PTX3 in vascular biology
Presta, M., Camozzi, M., Salvatori, G., & Rusnati, M. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00061.x · Cited by 181 · see citing works
C-Reactive Protein in Atherosclerotic Lesions
Sun, H., Koike, T., Ichikawa, T., Hatakeyama, K., Shiomi, M., Zhang, B., Kitajima, S., Morimoto, M., Watanabe, T., Asada, Y., et al. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61202-3 · Cited by 166 · see citing works
Self-citationAssociations of Pentraxin 3 With Cardiovascular Disease and All-Cause Death
Jenny, N. S., Arnold, A. M., Kuller, L. H., Tracy, R. P., & Psaty, B. M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.178947 · Cited by 163 · see citing works
Devaraj, S., & Jialal, I. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.225508 · Cited by 156 · see citing works
Ray, K. K., Cannon, C. P., Cairns, R., Morrow, D. A., Ridker, P. M., & D, E. B. M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.181735 · Cited by 155 · see citing works
Sato, Y. Z., Hatakeyama, K., Yamashita, A., Marutsuka, K., Sumiyoshi, A., & Asada, Y. (2005) · Heart · doi:10.1136/hrt.2004.034058 · Cited by 134 · see citing works
Self-citationDoni, A., Mosca, M., Bottazzi, B., Peri, G., Valentino, S., Polentarutti, N., Garlanda, C., & Mantovani, A. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0905493 · Cited by 116 · see citing works
Ishikawa, T., Hatakeyama, K., Imamura, T., Date, H., Shibata, Y., Hikichi, Y., Asada, Y., & Eto, T. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)03156-9 · Cited by 113 · see citing works
Self-citationCoregulation in human leukocytes of the long pentraxin PTX3 and TSG-6
Maina, V., Cotena, A., Doni, A., et al. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0608345 · Cited by 91 · see citing works
The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility
Bottazzi, B., Bastone, A., Doni, A., et al. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1005557 · Cited by 89 · see citing works
Homma, Y. (2004) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.11.265 · Cited by 78 · see citing works
Petschner, F., Zimmermann, C., Strasser, A., Grillot, D., Núñez, G., & Pircher, H. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199802)28:02 · Cited by 77 · see citing works
van Rossum, A. P., Pas, H. H., Fazzini, F., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21669 · Cited by 64 · see citing works
Vré, E. A. V., Bult, H., Hoymans, V. Y., Tendeloo, V. F. V., Vrints, C. J., & Bosmans, J. M. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.157016 · Cited by 53 · see citing works
Nishihira, K. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl058 · Cited by 48 · see citing works
Yunoki, K., Naruko, T., Komatsu, R., Ehara, S., Shirai, N., Sugioka, K., Nakagawa, M., Kitabayashi, C., Ikura, Y., Itoh, A., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp257 · Cited by 43 · see citing works
SOLEM, J., Levin, M., KARLSSON, T., et al. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01608.x · Cited by 18 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Libby P, Ridker PM, Hansson GK: Inflammation in ath- erosclerosis: from pathophysiology to practice. J Am Coll Cardiol, 2009; 54: 2129-2138
- Boyle JJ, Harrington HA, Piper E, Elderfield K, Stark J, Landis RC, Haskard DO: Coronary intraplaque hemor- rhage evokes a novel atheroprotective macrophage pheno- type. Am J Pathol, 2009; 174: 1097-1108
- Polentarutti N, Picardi G, Basile A, Cenzuales S, Rivolta A, Matteucci C, Peri G, Mantovani A, Introna M: Inter- feron-gamma inhibits expression of the long pentraxin PTX3 in human monocytes. Eur J Immunol, 1998; 28: 496-501
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Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
- Authors
- Matsuura, Y., Hatakeyama, K., Imamura, T., Tsuruda, T., Shibata, Y., Kodama, T., Kitamura, K., & Asada, Y.
- Affiliations
- University of Miyazaki (JP)
- Miyazaki Medical Association Hospital (JP)
- Research Center for Advanced Science and Technology, The University of Tokyo (JP)
- ORCID
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2012
- Volume
- 19
- Issue
- 9
- Pages
- 837-845
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W2086611357
- Cited by
- 31
- References
- 36
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 1 · 2022: 2 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (20590344, 23390084)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- pentraxin 3, C-reactive protein, coronary plaque, intraplaque hemorrhage, lipid-rich plaque, fibroatheroma, M2 macrophages, CD163, CD68, unstable angina, stable angina, culprit plaque, inflammation in atherosclerosis
- MeSH terms
- CD163 Antigen, Pentraxins, Serum Amyloid P-Component, Angina, Unstable, Autopsy, C-Reactive Protein, Coronary Artery Disease, Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Receptors, Cell Surface, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Atherectomy, Coronary, Plaque, Atherosclerotic, Angina, Stable
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