Control Status of Atherosclerotic Cardiovascular Risk Factors Among Japanese High-Risk Subjects:Analyses of a Japanese Health Check Database from 2008 to 2011
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AIMS: Several guidelines propose target levels (TLs) of atherosclerotic risk factors (ARFs) to reduce atherosclerotic cardiovascular diseases; however, few data are available regarding the attainment statuses of TLs in Japan. In this study, utilizing the data obtained from the annual "Specific Health Check and Guidance in Japan" conducted from 2008 to 2011 (approximately 280,000 subjects each year), we determined TL attainments of ARFs in cardiovascular high-risk subjects. METHODS: Those who had suffered from cerebrovascular disease (pCVD) or coronary heart disease (pCHD) or were receiving diabetes mellitus treatment (DM) were selected, and the rates of subjects that attained TLs of blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs) and glycated hemoglobin (HbA1c) were analyzed. RESULTS: Approximately 70% of pCVD or pCHD and 35% of subjects with DM attained TLs of BP. With regard to HbA1c, ＞90% of pCVD or pCHD and approximately 50% of subjects with DM attained TLs. With regard to LDL-C, ＜25% of pCHD females and approximately 35% of pCHD males and 50%-55% of subjects with pCVD or DM attained TLs. The TL-attainment rates of HDL-C and TGs were approximately 90% and 75%, respectively, for the three diseases. Analyses of time course changes in their attainment statuses revealed that the attainment rates of BP and LDL-C significantly improved in all the diseases. CONCLUSIONS: TL-attainment rates of BP and LDL-C were not as high as those for HDL-C, TGs, and HbA1c; however, they both showed highly significant improvements during the study period.
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Keeping the LDL-C level < 120 mg/dL is useful for preventing CAD incidence in diabetes patients.
“Furthermore, for diabetes patients, who are a high-risk group in primary prevention, a sub-analysis of the J-LIT study results found that keeping the LDL-C level < 120 mg/dL was useful for preventing CAD incidence625).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [625]
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- Authors
- Hasegawa, K., Tsukamoto, K., Kunimi, M., Asahi, K., Iseki, K., Moriyama, T., Yamagata, K., Tsuruya, K., Fujimoto, S., Narita, I., Konta, T., Kondo, M., Kimura, K., Ohashi, Y., & Watanabe, T.
- Affiliations
- Fukushima Medical University (JP)
- Steering Committee for “Design of the comprehensive health care system for chronic kidney disease (CKD) based on the individual risk assessment by Specific Health Checkups”
- Chuo University (JP)
- ORCID
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2016
- Volume
- 23
- Issue
- 8
- Pages
- 991-1003
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- PMC
- PMC7399292
- OpenAlex
- W2311978721
- Cited by
- 10
- References
- 21
- Citations by year
- 2025: 1 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 1
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Funders
- Japan Agency for Medical Research and Development
- Ministry of Health, Labour and Welfare
- Japan Society for the Promotion of Science (16K08860)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- target levels, blood pressure control, LDL cholesterol, HDL cholesterol, triglycerides, HbA1c, coronary artery disease, cerebrovascular disease, diabetes mellitus, Japan
- MeSH terms
- Adult, Aged, Blood Pressure, Cerebrovascular Disorders, Coronary Artery Disease, Female, Glycated Hemoglobin, Humans, Japan, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Risk Factors, Time Factors, Triglycerides, Databases, Factual, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Atherosclerosis
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