Interferon-stimulated gene 20-kDa protein (ISG20) in infection and disease: Review and outlook
Open accessAbstract
Interferon-stimulated exonuclease gene 20 (ISG20) is an RNA exonuclease in the yeast RNA exonuclease 4 homolog (REX4) subfamily and the DEDDh exonuclease family, and this gene codes for a 20-kDa protein. Those exonucleases are involved in cleaving single-stranded RNA and DNA. ISG20 is also referred to as HEM45 (HeLa estrogen-modulated, band 45). Expression of ISG20 can be induced or regulated by both type I and II interferons (IFNs) in various cell lines. ISG20 plays a role in mediating interferon's antiviral activities. In addition, ISG20 may be a potential susceptibility biomarker or pharmacological target in some inflammatory conditions. Exonucleases are useful components of many physiological processes. Despite recent advances in our understanding of the functions of ISG20, much work remains to be done with regard to uncovering the mechanism of action of ISG20 in specific diseases and adapting ISG20 for use as a biomarker of disease. This review describes current information on ISG20 and its potential use in marking disease. This review describes several research achievements thus far and it seeks to provide some new ideas for future related research.
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The consensus IFN-γ signature included JAK-STAT pathway genes such as STAT1 and IRF1 and antiviral response genes such as MX1, OAS3, ISG20, and RSAD2.
“This consensus signature includes activation of genes in the JAK-STAT pathway, including STAT1 and IRF1 (ref.38), and in the IFN-mediated antiviral response, including MX1, OAS3, ISG20 and RSAD2 (refs.39–41).”
From Quantifying the effect of experimental perturbations at single-cell resolution (2021) · cites this paper as [41]
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Cited by
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Quantifying the effect of experimental perturbations at single-cell resolution
Burkhardt, D. B., Stanley, J. S., Tong, A., Perdigoto, A. L., Gigante, S. A., Herold, K. C., Wolf, G., Giraldez, A. J., van Dijk, D., & Krishnaswamy, S. (2021) · Nature Biotechnology · doi:10.1038/s41587-020-00803-5 · Cited by 226 · see citing works
- Authors
- Zheng, Z., Wang, L., & Pan, J.
- Affiliations
- University of Jinan (CN)
- Shandong Medicinal Biotechnology Center
- Venue
- Intractable & Rare Diseases Research
- Publisher
- International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)
- Published
- 2017
- Volume
- 6
- Issue
- 1
- Pages
- 35-40
- ISSN
- 2186-361X (ISSN-L)
- 2186-3644
- PMC
- PMC5359350
- OpenAlex
- W2590930938
- Cited by
- 38
- References
- 43
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 1 · 2018: 5 · 2017: 1
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Intractable & Rare Diseases Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81671624)
- Natural Science Foundation of Shandong Province (ZR2015YL029)
- Shandong Academy of Medical Sciences
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- ISG20, RNA exonuclease, interferon-stimulated genes, type I interferon, interferon-gamma, antiviral activity, biomarkers of susceptibility, therapeutic target, inflammatory diseases
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