Cited by 38interferon and immune responsesRNA regulation and diseaseRNA Research and Splicing

Interferon-stimulated gene 20-kDa protein (ISG20) in infection and disease: Review and outlook

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Zheng, Zhiwei, Wang, Lin, Pan, Jihong·2017·Intractable & Rare Diseases Research

Abstract

Interferon-stimulated exonuclease gene 20 (ISG20) is an RNA exonuclease in the yeast RNA exonuclease 4 homolog (REX4) subfamily and the DEDDh exonuclease family, and this gene codes for a 20-kDa protein. Those exonucleases are involved in cleaving single-stranded RNA and DNA. ISG20 is also referred to as HEM45 (HeLa estrogen-modulated, band 45). Expression of ISG20 can be induced or regulated by both type I and II interferons (IFNs) in various cell lines. ISG20 plays a role in mediating interferon's antiviral activities. In addition, ISG20 may be a potential susceptibility biomarker or pharmacological target in some inflammatory conditions. Exonucleases are useful components of many physiological processes. Despite recent advances in our understanding of the functions of ISG20, much work remains to be done with regard to uncovering the mechanism of action of ISG20 in specific diseases and adapting ISG20 for use as a biomarker of disease. This review describes current information on ISG20 and its potential use in marking disease. This review describes several research achievements thus far and it seeks to provide some new ideas for future related research.

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Crossref · 10.5582/irdr.2017.01004

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  • The consensus IFN-γ signature included JAK-STAT pathway genes such as STAT1 and IRF1 and antiviral response genes such as MX1, OAS3, ISG20, and RSAD2.

    “This consensus signature includes activation of genes in the JAK-STAT pathway, including STAT1 and IRF1 (ref.38), and in the IFN-mediated antiviral response, including MX1, OAS3, ISG20 and RSAD2 (refs.39–41).”

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  1. Chen XM, Huang QC, Yang SL, Chu YL, Yan YH, Han L, Huang Y, Huang RY. Role of microRNAs in the pathogenesis of rheumatoid arthritis: Novel perspectives based on review of the literature. Medicine (Baltimore). 2015; 94:e1326.
  2. Zhao Y, Wang L, Pan J. The development of research about microRNAs in rheumatoid arthritis. Chinese Bulletin of Life Sciences. 2015; 1140-1145. (in Chinese)
  3. Jiang D, Guo H, Xu C, Chang J, Gu B, Wang L, Block TM, Guo JT. Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus. J Virol. 2008; 82:1665-1678.

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Authors
Zheng, Z., Wang, L., & Pan, J.
Affiliations
  • University of Jinan (CN)
  • Shandong Medicinal Biotechnology Center
Venue
Intractable & Rare Diseases Research
Published
2017
Volume
6
Issue
1
Pages
35-40
ISSN
  • 2186-361X (ISSN-L)
  • 2186-3644
OpenAlex
W2590930938
Cited by
38
References
43
Citations by year
2025: 4 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 1 · 2018: 5 · 2017: 1
FWCI
0.37
Type
journal article
Language
en
Open access
Locations
  • Intractable & Rare Diseases Research (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81671624)
  • Natural Science Foundation of Shandong Province (ZR2015YL029)
  • Shandong Academy of Medical Sciences
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
ISG20, RNA exonuclease, interferon-stimulated genes, type I interferon, interferon-gamma, antiviral activity, biomarkers of susceptibility, therapeutic target, inflammatory diseases

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