New functions of 20-hydroxyecdysone in lipid peroxidation
Open accessAbstract
The antioxidizig action of 20-hydroxyecdysone was investigated in several systems in vitro. Changes in the parameters of chemiluminescence in the presence of 20-hydroxyecdysone were found in rat liver mitochondrial fractions. The effect of 20-hydroxyecdysone on methyl linoleate micelles free radical oxidation was studied. The rate of oxygen uptake in methyl linoleate micelles was found to be smaller when 20-hydroxyecdysone was present than at its absence. The action of 20-hydroxyecdysone in the liposomal membranes oxidation was investigated be means of α-tocopherol consumption. A lower rate of α-tocopherol consumption in the oxidation of liposomal membranes was found when 20-hydroxyecdysone was present. The effect of cholesterol on free radical formation in liposomal membranes was investigated. The rate of free-radical formation was smaller when cholesterol was present in the membrane than in membranes free of cholesterol. The α-tocopherol antioxidant effect in the membrane was also lower when cholesterol was present. We show here for the first time that 20-hydroxyecdysone has an antioxidant action in combination with α-tocopherol in membranes with cholesterol overload. Kinetic measurements were revealed the 20-hydroxyecdysone antioxidant effect on free radical reactions in membranes.
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20-HE intervenes with liposomal membrane oxidation in rat liver mitochondrial fractions.
“The antioxidant effects of 20-HE on rat liver mitochondrial fractions were analyzed, and showed that it intervenes with the liposomal membrane oxidation178.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [178]
20-HE reduced free-radical formation in a cholesterol-dependent manner, while α-tocopherol showed lower antioxidant effect in the membrane.
“The rate of free-radical formation was reduced by 20-HE in cholesterol-dependent manner, while α-tocopherol showed lower antioxidant effect in the membrane.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [178]
20-HE showed potent antioxidant action in combination with α-tocopherol in membranes containing excess cholesterol, indicating a free radical scavenging mechanism.
“20-HE showed potent antioxidant action in combination with α-tocopherol in membranes that contain excess cholesterol, which indicates the free radical scavenging mechanism178.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [178]
Several published reports have written about the ROS-scavenger and antioxidant properties of 20E in several in vitro and in vivo systems.
“Several published reports have written about the ROS-scavenger and antioxidant properties of 20E in several in vitro [30,31] and in vivo systems [32,33].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [30]
20E has previously been shown to possess antioxidant capacities in both in vitro systems and non-cancer cells.
“As 20E has previously been shown to possess antioxidant capacities in both in vitro systems and non-cancer cells [30,31,32]”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [30]
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References 14 · Cited by 17
- Authors
- I. KUZMENKO, A., NIKI, E., & NOGUCHI, N.
- Affiliations
- Research Center for Advanced Science and Technology, The University of Tokyo (JP)
- ORCID
- NOGUCHI, Noriko
- Venue
- Journal of Oleo Science
- Publisher
- Japan Oil Chemists' Society
- Published
- 2001
- Volume
- 50
- Issue
- 6
- Pages
- 497-506
- ISSN
- 1341-8327 (ISSN-L)
- 1345-8957
- 1347-3352
- OpenAlex
- W2011018468
- Cited by
- 17
- References
- 14
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2014: 1 · 2012: 2
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Oleo Science (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- 20-hydroxyecdysone, lipid peroxidation, antioxidant activity, free radical oxidation, chemiluminescence, mitochondrial membrane, liposomal membranes, alpha-tocopherol, cholesterol, oxygen consumption, ecdysteroids
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