Objective sleep assessments in patients with postural tachycardia syndrome using overnight polysomnograms
Open accessAbstract
Study objectives Patients with postural tachycardia syndrome (POTS) commonly complain of fatigue, unrefreshing sleep, daytime sleepiness, and diminished quality of life. The study objective was to assess objective sleep quality in POTS patients using overnight polysomnography. Methods We studied 16 patients with POTS and 15 healthy control subjects performing daytime autonomic functions tests and overnight polysomnography at the Vanderbilt Clinical Research Center. Results There were no significant differences in the objective sleep parameters including sleep efficiency, sleep onset latency, wake time after sleep onset, REM latency, percentage of time spent in N1, N2, N3, and REM sleep, arousal index, apnea-hypopnea index, or periodic leg movement index in POTS patients as compared with healthy control subjects. There were significant negative correlations between sleep efficiency and the change in HR from supine to stand (rs = -0.527; p = 0.036). Conclusions POTS patients do not have significant differences in objective sleep parameters as compared to control subjects based on overnight polysomnograms. Activation of the sympathetic nervous system may contribute significantly to the hyper arousal state and worsening of subjective estimates of sleep quality as previously reported in POTS patients.
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A potential etiology for the link between supine HR and sleep efficiency is less refreshing sleep due to increased sympathetic activation.
“a potential etiology for this link is less refreshing sleep due to increased sympathetic activation (84).”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [84]
The Polysomnogram Correlations section (page not provided) proposes that increased sympathetic activity may reduce sleep efficiency and lead to less restful sleep. But the reported link is with the change in heart rate from supine to standing, not supine heart rate itself. (LLM, conf=0.86)
Experimental — accuracy not yet measuredA negative correlation between supine HR and sleep efficiency has been noted.
“A negative correlation between supine HR and sleep efficiency has been noted;”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [84]
The 'Correlation between Polysomnogram Data and Autonomic Data' section reports negative correlations between sleep efficiency and maximal standing HR and the change in HR from supine to standing in POTS patients. It does not report a negative correlation with supine HR itself; the claim substitutes a different HR measure. (LLM, conf=0.87)
Experimental — accuracy not yet measuredIn POTS patients who do get overnight polysomnography, no objective sleep parameter abnormalities are typically identified, and findings are comparable to those of healthy controls.
“In POTS patients who do get overnight polysomnography, no objective sleep parameter abnormalities are typically identified, and findings are comparable to those of healthy controls (84,85).”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [84]
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- Authors
- Bagai, K., Peltier, A. C., Malow, B. A., Diedrich, A., Shibao, C. A., Black, B. K., Paranjape, S. Y., Orozco, C., Biaggioni, I., Robertson, D., & Raj, S. R.
- Affiliations
- Vanderbilt University (US)
- University of Calgary (CA)
- ORCID
- Venue
- Journal of Clinical Sleep Medicine
- Published
- 2016-05-15
- Volume
- 12
- Issue
- 5
- Pages
- 727-733
- ISSN
- 1550-9389 (ISSN-L)
- 1550-9397
- PMC
- PMC4865560
- OpenAlex
- W2347259464
- Cited by
- 17
- References
- 8
- Citations by year
- 2026: 1 · 2023: 2 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 2
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Sleep Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vanderbilt University
- National Heart, Lung, and Blood Institute (R01HL071784, P01HL056693, R01HL102387)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD083211)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Keywords
- postural orthostatic tachycardia syndrome, sleep quality, overnight polysomnography, sleep efficiency, autonomic dysfunction, sympathetic activation, hyperarousal, daytime sleepiness, sleep architecture
- MeSH terms
- Adult, Female, Humans, Male, Sleep, Sleep Wake Disorders, Polysomnography, Postural Orthostatic Tachycardia Syndrome
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