Psychiatric profile and attention deficits in postural tachycardia syndrome
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OBJECTIVES: Patients with postural tachycardia syndrome (POTS) often appear anxious and report inattention. Patients with POTS were formally assessed for psychiatric disorders and inattention and compared with patients with attention deficit hyperactivity disorder (ADHD) and control subjects. METHODS: Patients with POTS (n = 21), ADHD (n = 18) and normal control subjects (n = 20) were assessed for DSM-IV psychiatric disorders and completed a battery of questionnaires that assessed depression, anxiety and ADHD characteristics. RESULTS: Patients with POTS did not have an increased prevalence of major depression or anxiety disorders, including panic disorder, compared with the general population. Patients with POTS had mild depression. They scored as moderately anxious on the Beck Anxiety Inventory but did not exhibit a high level of anxiety sensitivity. Patients with POTS scored significantly higher on inattention and ADHD subscales than control subjects. These symptoms were not present during childhood. CONCLUSIONS: Patients with POTS do not have an increased lifetime prevalence of psychiatric disorders. Although they may seem anxious, they do not have excess cognitive anxiety. They do experience significant inattention which may be an important source of disability.
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Patients with POTS do not have an increased prevalence of anxiety disorders, including panic disorder, compared with the general population.
“Furthermore, formal assessment for psychiatric disorders has shown that patients with POTS do not have an increased prevalence of anxiety disorders, including panic disorder, compared with the general population.38”
From Hyperadrenergic Postural Tachycardia Syndrome: Clinical Biomarkers and Response to Guanfacine (2024) · cites this paper as [38]
A structured evaluation using DSM-IV-TR criteria did not find a higher incidence of major depressive disorder, anxiety disorders, or substance abuse in POTS patients than in the general population.
“Yet a structured evaluation using criteria from the Diagnostic and Statistical Manual (fourth edition, text revision) did not identify a higher incidence of major depressive disorder, anxiety disorders, or substance abuse in POTS patients than the general population [27].”
From Postural tachycardia syndrome: beyond orthostatic intolerance (2015) · cites this paper as [27]
Studies suggest the true prevalence of psychiatric disorders in POTS patients may be no different than in the general population.
“especially in light of studies that suggest the true prevalence of psychiatric disorders in this patient population may be no different than in the general population (75).”
From Postural orthostatic tachycardia syndrome: mechanisms and new therapies (2020) · cites this paper as [75]
When formally assessed, POTS patients have no increased lifetime prevalence of psychiatric disorders as compared to the general population.
“When formally assessed, POTS patients have no increased lifetime prevalence of psychiatric disorders as compared to the general population, 29”
From The face of postural tachycardia syndrome – insights from a large cross‐sectional online community‐based survey (2019) · cites this paper as [29]
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Psychological and Psychiatric Support; When, Why and What to Do
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Self-citationThe Neuropsychological Profile of Postural Orthostatic Tachycardia Syndrome: Sibling Case Study
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- Authors
- Raj, V, Haman, K. L., Raj, S. R., Byrne, D., Blakely, R. D., Biaggioni, I., Robertson, D., & Shelton, R. C.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Shelton, R C
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2009-03-01
- Volume
- 80
- Issue
- 3
- Pages
- 339-344
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC2758320
- OpenAlex
- W2149406742
- Cited by
- 131
- References
- 25
- Citations by year
- 2026: 13 · 2025: 7 · 2024: 11 · 2023: 3 · 2022: 9 · 2021: 12 · 2020: 5 · 2019: 6 · 2018: 13 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 7 · 2013: 8 · 2012: 1
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Vanderbilt University
- National Heart, Lung, and Blood Institute (P01HL056693)
- National Institute of Neurological Disorders and Stroke (R01NS055670)
- National Center for Research Resources (M01RR000095, KL2RR024977, TL1RR024978, UL1RR024975, K23RR020783)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- postural orthostatic tachycardia syndrome, psychiatric comorbidity, inattention, attention deficit hyperactivity disorder, anxiety, depression, anxiety sensitivity, panic disorder
- MeSH terms
- Adolescent, Aged, Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Cross-Sectional Studies, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Personality Inventory, Comorbidity, Panic Disorder, Diagnostic and Statistical Manual of Mental Disorders, Postural Orthostatic Tachycardia Syndrome, Young Adult
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