Sensory axonal polyneuropathy due to 2,4-dinitrophenol
Open accessAbstract
A 24-year-old man developed subacute onset of numbness and pain in the upper and lower limbs. Physical examination demonstrated decreased pinprick sensation, but was otherwise normal. Blood and cerebrospinal fluid parameters were normal except for mild hepatic dysfunction. No data were suggestive of connective tissue disease. Nerve conduction studies demonstrated sensory neuropathy. A detailed medical interview revealed that the patient had been taking self-imported 2,4-dinitrophenol (DNP) for 2 months to decrease body weight. Six months after discontinuing DNP, subjective symptoms and liver dysfunction resolved completely, and the patient was diagnosed with drug-induced peripheral neuropathy and hepatopathy. There are no case reports of health risks posed by DNP in Japan, and even worldwide, cases of peripheral neuropathy due to DNP are rare. Obtaining a detailed drug history is important, as is providing information on the dangers of self-imported medicines.
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Cites
2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death
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Mitochondrial uncoupling as a target for drug development for the treatment of obesity.
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ACTIONS AND USES OF DINITROPHENOL
Cutting, W., MEHRTENS, H. G., & Tainter, M. L. (1933) · JAMA · doi:10.1001/jama.1933.02740280013006 · Cited by 138 · see citing works
Two Deaths Attributed to the Use of 2,4-Dinitrophenol
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Deliberate poisoning with dinitrophenol (DNP): an unlicensed weight loss pill
Bartlett, J., Brunner, M., & Gough, K. (2010) · Emergency Medicine Journal · doi:10.1136/emj.2008.069401 · Cited by 56 · see citing works
'Fatal 2,4-dinitrophenol poisoning... coming to a hospital near you'
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Peripheral neuropathy due to dinitrophenol used for weight loss: something old, something new
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PERIPHERAL NEURITIS CAUSED BY PROLONGED USE OF DINITROPHENOL
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Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases
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“The reported side effects of DNP include acute cataract [261,262], sensory axonal polyneuropathy [263], fever, tachycardia, sweating, nausea, rash, breathing difficulties, abdominal pain, agitation, headache, and death [264,265].”
Background
- Authors
- Izumoto, S., Taniguchi, A., Mochizuki, H., Shiomi, K., & Nakazato, M.
- Affiliations
- University of Miyazaki (JP)
- Venue
- Rinsho Shinkeigaku
- Publisher
- Societas Neurologica Japonica
- Published
- 2017
- Volume
- 57
- Issue
- 10
- Pages
- 599-602
- ISSN
- 0009-918X (ISSN-L)
- 1882-0654
- OpenAlex
- W2760102721
- Cited by
- 1
- References
- 8
- Citations by year
- 2019: 1
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Rinsho Shinkeigaku (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Keywords
- 2,4-dinitrophenol, drug-induced peripheral neuropathy, liver disease, weight loss supplements, drug history, liver dysfunction
- MeSH terms
- Adult, Humans, Japan, Male, Neural Conduction, Peripheral Nervous System Diseases, Polyneuropathies, Self Medication, Illicit Drugs, 2,4-Dinitrophenol, Anti-Obesity Agents, Somatosensory Disorders, Young Adult, Chemical and Drug Induced Liver Injury
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