The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Functional Group Selective Derivatization and Gas-Phase Fragmentation Reactions of Plasmalogen Glycerophospholipids
Abstract
A reaction strategy involving functional group selective modification of the O-alkenyl-ether double bond within plasmenyl ether containing lipids using iodine and methanol, in conjunction with functional group selective derivatization of amine-containing lipids using a novel (13)C1-S,S'-dimethylthiobutanoylhydroxysuccinimide ester ((13)C1-DMBNHS) reagent, is shown to improve the capabilities of 'shotgun' high resolution/accurate mass spectrometry for comprehensive lipidome analysis. Importantly, the characteristic mass shifts introduced as a result of these derivatization reactions enables the resolution and unambiguous identification of isobaric mass plasmenyl- and plasmanyl-ether containing lipid species from within crude complex lipid extracts, without need for chromatographic fractionation or additional lipid extraction steps prior to analysis. Additionally, the positive ionization mode tandem mass spectrometry fragmentation behavior of the derivatized plasmenyl ether containing glycerophosphocholine and glycerophosphoethanolamine lipids are shown to yield abundant characteristic product ions that directly enable the assignment of their molecular lipid identities.
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“Charge-switch derivatization strategies have been successfully used to improve detection in a range of lipid species (50, 51) and there is a chemical derivatization strategy that can impart a fixed positive charge on PE and phosphatidylserine aminophospholipids and increase sensitivity for such lipid species (52, 53, 54, 55).”
From FACS-assisted single-cell lipidome analysis of phosphatidylcholines and sphingomyelins in cells of different lineages (2023) · cites this paper as [52]
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Cited by
Characterization and multiplexed quantification of derivatized aminophospholipids
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Self-citationHancock, S. E., Ding, E., Johansson Beves, E., Mitchell, T., & Turner, N. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100341 · Cited by 13
Metadata
- Authors
- Fhaner, C. J., Liu, S., Zhou, X., & Reid, G. E.
- Venue
- Mass Spectrometry
- Published
- 2013
- Volume
- 2
- Issue
- Special_Issue
- Pages
- S0015-S0015
- ISSN
- 2187-137X
- Cited by
- 33
- References
- 29
- Language
- en
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