Functions of plasmalogen lipids in health and disease

Alzheimer’s disease

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A comprehensive classification system for lipids

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Plasmalogens: biosynthesis and functions

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Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

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Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders

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Lipid Rafts Are Enriched in Arachidonic Acid and Plasmenylethanolamine and Their Composition Is Independent of Caveolin-1 Expression: A Quantitative Electrospray Ionization/Mass Spectrometric Analysis

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Functions and biosynthesis of plasmalogens in health and disease

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Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

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Severe Alterations in Lipid Composition of Frontal Cortex Lipid Rafts from Parkinson’s Disease and Incidental Parkinson’s Disease

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A possible role for plasmalogens in protecting animal cells against photosensitized killing.

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Severe plasmalogen deficiency in tissues of infants without peroxisomes (Zellweger syndrome)

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Old and new generation lipid mediators in acute inflammation and resolution

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Metabolic Effects of Krill Oil are Essentially Similar to Those of Fish Oil but at Lower Dose of EPA and DHA, in Healthy Volunteers

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EFFECTS OF DIETARY FATS ON HUMAN ERYTHROCYTE FATTY ACID PATTERNS*

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Electrospray ionization tandem mass spectrometry of glycerophosphoethanolamine plasmalogen phospholipids

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Mammalian Wax Biosynthesis

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Plasmalogens as endogenous antioxidants: somatic cell mutants reveal the importance of the vinyl ether

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The alk-1-enyl group content of mammalian myelin phosphoglycerides by quantitative two-dimensional thin-layer chromatography

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Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia

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Mechanisms of glycerophospholipid homeostasis in mammalian cells

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Disease and anatomic specificity of ethanolamine plasmalogen deficiency in Alzheimer's disease brain

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Book Review: Plasmalogens: Workhorse Lipids of Membranes in Normal and Injured Neurons and Glia

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Peroxisomal alterations in Alzheimer’s disease

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Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease

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Ether lipids in biomembranes

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Disturbed Choline Plasmalogen and Phospholipid Fatty Acid Concentrations in Alzheimer's Disease Prefrontal Cortex

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Alzheimer’s disease: the lipid connection

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Identification of plasmalogen as the major phospholipid constituent of cardiac sarcoplasmic reticulum

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Lipid Alterations in the Earliest Clinically Recognizable Stage of Alzheimers Disease: Implication of the Role of Lipids in the Pathogenesis of Alzheimers Disease

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The protective role of plasmalogens in iron-induced lipid peroxidation

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Adult rat brain synaptic vesicles II. Lipid composition

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Identification of PEX7 as the second gene involved in Refsum disease

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Interactions of plasmalogens and their diacyl analogs with singlet oxygen in selected model systems

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Circulating plasmalogen levels and Alzheimer Disease Assessment Scale–Cognitive scores in Alzheimer patients

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Use of three‐dimensional ultrasound imaging in the diagnosis of prenatal‐onset skeletal dysplasias

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Zellweger syndrome: Diagnostic assays, syndrome delineation, and potential therapy

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The appearance, disappearance and reappearance of plasmalogens in evolution

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Plasmenylcholine and phosphatidylcholine membrane bilayers possess distinct conformational motifs

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Mutation analysis ofPEX7 in 60 probands with rhizomelic chondrodysplasia punctata and functional correlations of genotype with phenotype

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Alkyl-Glycerol Rescues Plasmalogen Levels and Pathology of Ether-Phospholipid Deficient Mice

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Posttranslational Regulation of Fatty Acyl-CoA Reductase 1, Far1, Controls Ether Glycerophospholipid Synthesis

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Impaired membrane traffic in defective ether lipid biosynthesis

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Natural history of rhizomelic chondrodysplasia punctata

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Plasmalogens in Human Serum Positively Correlate with High- Density Lipoprotein and Decrease with Aging

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Metabolic Profiling Reveals Distinct Variations Linked to Nicotine Consumption in Humans — First Results from the KORA Study

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Plasmalogen synthesis is regulated via alkyl‐dihydroxyacetonephosphate‐synthase by amyloid precursor protein processing and is affected in Alzheimer’s disease

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Deficiency in ethanolamine plasmalogen leads to altered cholesterol transport

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Phospholipid composition and levels are altered in down syndrome brain

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Biosynthesis and possible biological functions of plasmalogens

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Plasmalogens participate in very-long-chain fatty acid-induced pathology

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Naturally derived commercial surfactants differ in composition of surfactant lipids and in surface viscosity

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MRI of the brain and cervical spinal cord in rhizomelic chondrodysplasia punctata

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Dietary ether lipid incorporation into tissue plasmalogens of humans and rodents

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Increasing plasmalogen levels protects human endothelial cells during hypoxia

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Lipoproteins secreted by cultured rat hepatocytes contain the antioxidant 1-alk-1-enyl-2-acylglycerophosphoethanolamine

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MALDI imaging MS of phospholipids in the mouse lung

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Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin

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Positions of double bonds in the monounsaturated alk-1-enyl groups from the plasmalogens of human heart and brain

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Chondrodysplasia punctata — Rhizomelic form

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Peroxisomal Impairment in Niemann-Pick Type C Disease

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Meats and Fish Consumed in the American Diet Contain Substantial Amounts of Ether-Linked Phospholipids

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Plasmalogen Phospholipids Are Involved in HDL-Mediated Cholesterol Efflux: Insights from Investigations with Plasmalogen-Deficient Cells

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Isolation and characterization of mutant animal cell line defective in alkyl-dihydroxyacetonephosphate synthase: Localization and transport of plasmalogens to post-Golgi compartments

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The Vinyl Ether Linkages of Plasmalogens Are Favored Targets for Myeloperoxidase-Derived Oxidants: A Kinetic Study

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Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment

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PRESIDENTIAL ADDRESS: The Pathology of Peroxisomal Disorders with Pathogenetic Considerations

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Low-Concentration Ozone Reacts with Plasmalogen Glycerophosphoethanolamine Lipids in Lung Surfactant

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Glyceryl-ether monooxygenase [EC 1.14.16.5]. A microsomal enzyme of ether lipid metabolism

Taguchi, H., & Armarego, W. L. F. (1998) · Medicinal Research Reviews · doi:10.1002/(sici)1098-1128(199801)18:1 · Cited by 48 · see citing works

Alzheimer's Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets

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Photosensitized killing of cultured fibroblasts from patients with peroxisomal disorders due to pyrene fatty acid-mediated ultraviolet damage.

Höefler, G., Paschke, E., Hoefler, S., Moser, A. B., & Moser, H. W. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115509 · Cited by 43 · see citing works

The ether lipid trail: a historical perspective1The original citations of the literature covered in this article only serve as a point of reference and are not intended to be all inclusive. For more comprehensive information about a given subject, the reader should consult the references cited in the review articles and books listed in this article or to search Medline or some similar database for the individual scientists mentioned only by last names and their initials in this review.1

Snyder, F. F. C. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s0005-2760(98)00172-6 · Cited by 43 · see citing works

Alkyl‐dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes

Biermann, J., Just, W. W., Wanders, R. J. A., & van den BOSCH, H. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00295.x · Cited by 39 · see citing works

Plasmalogens effectively reduce the surface tension of surfactant-like phospholipid mixtures

Rüdiger, M., Kolleck, I., Putz, G., et al. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.274.1.l143 · Cited by 39 · see citing works

In vitro and in vivo plasmalogen replacement evaluations in rhizomelic chrondrodysplasia punctata and Pelizaeus-Merzbacher disease using PPI-1011, an ether lipid plasmalogen precursor

Wood, P. L., Khan, M. A., Smith, T. M., Ehrmantraut, G., Jin, W., Cui, W., Braverman, N., & Goodenowe, D. B. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-182 · Cited by 38 · see citing works

Peroxisomal Disease Cell Lines with Cellular Plasmalogen Deficiency Have Impaired Muscarinic Cholinergic Signal Transduction Activity and Amyloid Precursor Protein Secretion

Périchon, R., Moser, A. B., Wallace, W., Cunningham, S. C., Roth, G. S., & Moser, H. W. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8909 · Cited by 37 · see citing works

Topography of ether phospholipid biosynthesis

Hardeman, D., & van den BOSCH, H. (1989) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(89)90315-9 · Cited by 37 · see citing works

Peroxisomes in airway epithelia and future prospects of these organelles for pulmonary cell biology

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Dietary supplementation with ether‐linked lipids and tissue lipid composition

Blank, M. L., Cress, E. A., Smith, Z. L., et al. (1991) · Lipids · doi:10.1007/bf02544013 · Cited by 33 · see citing works

The structure of pig heart plasmalogens

Marinetti, G. V., & Erbland, J. F. (1957) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(57)90028-8 · Cited by 32 · see citing works

Mouse brain plasmalogens are targets for hypochlorous acid-mediated modification in vitro and in vivo

Üllen, A., Fauler, G., Köfeler, H. C., Waltl, S., Nusshold, C., Bernhart, E. M., Reicher, H., Leis, H., Wintersperger, A., Malle, E., et al. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.08.025 · Cited by 31 · see citing works

Phospholipid analysis of human eosinophils: High levels of alkylacylglycerophosphocholine (PAF precursor)

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Oral ether lipid therapy in patients with peroxisomal disorders

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Rhizomelic Chondrodysplasia Punctata Type 1

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Fatty Alcohol Accumulation in the Autosomal Recessive Form of Rhizomelic Chondrodysplasia Punctata

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Delayed myelination in a rhizomelic chondrodysplasia punctata case: MR spectroscopy findings

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Plasmalogens and oxidative stress: evidence against a major role of plasmalogens in protection against the superoxide anion radical

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An Animal Cell Mutant with a Deficiency in Acyl/Alkyl-dihydroxyacetone-phosphate Reductase Activity

James, P. F., Lake, A. C., Hajra, A. K., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23540 · Cited by 24 · see citing works

Ether-linked phosphoglyceride content of human leukemia cells.

Chabot, M. C., Greene, D. G., Brockschmidt, J. K., et al. (1990) · PubMed · Cited by 22 · see citing works

Plasmalogen Deficit: A New and Testable Hypothesis for the Etiology of Alzheimer’s Disease

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Plasmalogen levels in full‐term neonates

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Fatty alcohol synthesis accompanied with chain elongation in liver peroxisomes

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Arachidonic acid metabolism in fibroblasts from patients with peroxisomal diseases: response to interleukin 1

Tiffany, C. W., Hoefler, S., Moser, H. W., et al. (1990) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(90)90010-m · Cited by 19 · see citing works

Plasmalogen content and β-adrenoceptor signalling in fibroblasts from patients with Zellweger syndrome. Effects of hexadecylglycerol

Styger, R., WIESMANN, U. N., & Honegger, U. E. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00320-7 · Cited by 17 · see citing works

Administration of Myo-inositol Plus Ethanolamine Elevates Phosphatidylethanolamine Plasmalogen in the Rat Cerebellum

Hoffman-Kuczynski, B., & Reo, N. V. (2005) · Neurochemical Research · doi:10.1007/s11064-004-9685-4 · Cited by 16 · see citing works

Identification of PEX7 as the Second Gene Involved in Refsum Disease

van den Brink, D. M., Brites, P., Haasjes, J., et al. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9072-3_9 · Cited by 15 · see citing works

ALKOXYGLYCEROLS AND THEIR USE IN RADIATION TREATMENT. AN EXPERIMENTAL AND CLINICAL STUDY.

Brohult, A. (1963) · PubMed · Cited by 15 · see citing works

Chondrodysplasia punctata (rhizomelic type): case report and pathologic findings.

Sugarman, G. I. (1974) · PubMed · Cited by 14 · see citing works

Rhizomelic chondrodysplasia punctata type 1 and fulminant neonatal respiratory failure, a case report and discussion of pathophysiology

Oswald, G. L., Lawson, C. S., Raymond, G. V., Golden, W. C., & Braverman, N. (2011) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.34331 · Cited by 13 · see citing works

Myocardial Salvage by Chimyl Alcohol: Possible Role of Peroxisomal Dysfunction in Reperfusion Injury

Maulik, N., Tósaki, Á., Engelman, R. M., et al. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb36752.x · Cited by 9 · see citing works

Lipoprotein[a] is not present in the plasma of patients with some peroxisomal disorders

van der Hoek, Y. Y., Wanders, R. J. A., van den Ende, A. E., et al. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37179-0 · Cited by 5 · see citing works

Untitled work

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A new pathway for mitochondrial quality control: Mitochondrial-derived vesicles

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Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling

Lodhi, I. J., & Semenkovich, C. F. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.002 · Cited by 605 · see citing works

Metabolic Interplay between Peroxisomes and Other Subcellular Organelles Including Mitochondria and the Endoplasmic Reticulum

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Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism

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Redox interplay between mitochondria and peroxisomes

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Peroxisomes in brain development and function

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Plasmalogens and Alzheimer’s disease: A review

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Peroxisome-mediated metabolism is required for immune response to microbial infection

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Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies

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Organelle interplay-peroxisome interactions in health and disease.

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A peroxisomal disorder of severe intellectual disability, epilepsy, and cataracts due to fatty acyl-CoA reductase 1 deficiency

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Plasmalogens rescue neuronal cell death through an activation of AKT and ERK survival signaling

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APP Function and Lipids: A Bidirectional Link

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Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?

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Dysfunctional high-density lipoproteins in coronary heart disease: implications for diagnostics and therapy

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Circulating Very-Long-Chain Saturated Fatty Acids and Incident Coronary Heart Disease in US Men and Women

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Deficiency of a Retinal Dystrophy Protein, Acyl-CoA Binding Domain-containing 5 (ACBD5), Impairs Peroxisomal β-Oxidation of Very-long-chain Fatty Acids

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A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform

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The neurology of rhizomelic chondrodysplasia punctata

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Distinct metabolic patterns during microglial remodeling by oleate and palmitate

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Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins

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Increasing acetyl-CoA metabolism attenuates injury and alters spinal cord lipid content in mice subjected to experimental autoimmune encephalomyelitis

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Peroxisomes and their central role in metabolic interaction networks in humans.

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Mild reduction of plasmalogens causes rhizomelic chondrodysplasia punctata: functional characterization of a novel mutation

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Analysis of Plasmalogen Synthesis in Cultured Cells

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Quantification of plasmalogen, alkylacyl and diacyl glycerophospholipids by micro-thin-layer chromatography

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Very large peroxisomes in distinct peroxisomal disorders (rhizomelic chondrodysplasia punctata and acyl-CoA oxidase deficiency): novel data

Craemer, D. D., Zweens, M. J., Lyonnet, S., et al. (1991) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01650683 · Cited by 25 · see citing works

The important role of biochemical and functional studies in the diagnostics of peroxisomal disorders

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