Polymorphic catechol-O-methyltransferase gene, soy isoflavone intake and breast cancer in postmenopausal women: a case-control study
Abstract
Background and objective Genetic polymorphism Val158Met of catechol-O-methyltransferase (COMT) may contribute to estrogen-induced carcinogenesis of breast cancer. Soy isoflavones possesses chemical structure similar to endogenous estrogen and may promote the carcinogenesis of breast cancer. This study was to investigate the relationship between the polymorphism of COMT, soy isoflavones, and breast cancer in postmenopausal women. Methods In total, 176 patients newly diagnosed histopathologically with breast cancer were recruited from May 2007 to July 2009, and 176 age-matched cancer-free women as controls were selected from a community-based physical check-up population at the same period. The food-frequency questionnaire was used to collect information on soy food intake. Allele-specific polymerase chain reaction (AS-PCR) was employed to analyze genetic polymorphism Val158Met of COMT. Adjusted odd ratios (aORs) and 95% confidence intervals (95% CI) were estimated by multivariable nonconditional logistic regression. Results The proportion of susceptible genotype (COMT-LL) in breast cancer patients was significantly higher than that in the controls. After adjusting selected risk factors, the aOR and 95% CI of COMT-LL were 3.14 (1.48-6.66) as compared with those of COMT-HH genotype. The intake of soy isoflavones had a negative correlation with breast cancer in a dose-dependent manner (Chi2 = 28.26, P or = 16.26 mg/d) and carrying susceptible genotype (COMT-LL), as compared with…
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Among case-control studies reporting odds ratios with confidence intervals, nine of 16 (56%) showed a significant inverse relationship between soy isoflavone intake and breast cancer risk.
“Of the 16 studies, nine (56%) showed a significant inverse relationship between soy isoflavone intake and risk of breast cancer [42,43,45,48,49,63,75,77,81].”
From Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review (2013) · cites this paper as [75]
Soy consumption may protect against the development of breast cancer, and less so against breast cancer recurrence and mortality, although this is based on observational data only.
“Our review suggests that on the contrary, soy consumption may protect against the development of breast cancer [46,75,109,117], and less so, breast cancer recurrence and mortality [106,112], although this is based on observational data only.”
From Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review (2013) · cites this paper as [75]
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Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review
Fritz, H., Seely, D., Flower, G., Skidmore, B., Fernandes, R., Vadeboncoeur, S., Kennedy, D., Cooley, K., Wong, R., Sagar, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081968 · Cited by 188 · see citing works
- Authors
- Wang, Q., Wang, Y.-P., Li, J.-Y., Yuan, P., Yang, F., & Li, H.
- Affiliations
- Sichuan University (CN)
- Venue
- Chinese Journal of Cancer
- Published
- 2010-07-05
- Volume
- 29
- Issue
- 7
- Pages
- 683-688
- ISSN
- 1000-467X (ISSN-L)
- 1944-446X
- OpenAlex
- W230796219
- Cited by
- 13
- References
- 0
- Citations by year
- 2026: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- 癌症：英文版 (publishedVersion)
- PubMed (publishedVersion)
- 癌症：英文版
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- catechol-O-methyltransferase, COMT Val158Met polymorphism, soy isoflavones, breast cancer, postmenopausal women, genetic susceptibility, estrogen-induced carcinogenesis, dose-dependent association, gene-diet interaction
- MeSH terms
- Adult, Aged, Breast Neoplasms, Catechol O-Methyltransferase, Codon, Female, Genotype, Humans, Isoflavones, Middle Aged, Polymorphism, Genetic, Risk Factors, Confidence Intervals, Odds Ratio, Case-Control Studies, Postmenopause, Genetic Predisposition to Disease, Soy Foods
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