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Hepatogastroenterology
Abstract
BACKGROUND/AIMS: Lysophosphatidic acid (LPA) has diverse biological activities implicated in tumor progression, including increasing cell migration, invasion and metastasis. However, the underlying mechanisms for LPA-induced human hepatocellular carcinoma (HCC) migration and invasion are poorly understood. METHODOLOGY: We sought to determine the promoting effect of LPA on HCC migration, invasion and adhesion by transwell and matrix adhesion assays, respectively. Levels of matrix metalloproteinase, MMP-2 and MMP- 9 from cells were assayed by ELISA and p38 mitogenactivated protein kinase (MAPK) signaling was determined by western blot analysis. RESULTS: In the present study, LPA was found to increase HCC cell migration, invasion and adhesion. In addition, LPA increased MMP-9 expression level and induced activation of the p38 mitogen- activated protein kinase (MAPK) signaling. Furthermore, pharmacological inhibition of p38 MAPK signal pathway with SB203580 significantly attenuated LPA-induced HCC cell migration, invasion, and adhesion and abrogated LPA-induced MMP-9 expression and p38 MAPK phosphorylation. CONCLUSIONS: We demonstrated a mechanism that LPA can activate p38 MAPK signaling, which is required for LPA-induced HCC cell migration, invasion, adhesion and MMP-9 expression, providing a novel biomarker and potential therapeutic target for HCC.
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Blei, A. T., & Córdoba, J. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03964.x · Cited by 527
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Munoz, P., Bouza, E., Cuenca-Estrella, M., Eiros, J. M., Perez, M. J., Sanchez-Somolinos, M., Rincon, C., Hortal, J., & Pelaez, T. (2005) · Clinical Infectious Diseases · doi:10.1086/429916 · Cited by 462
ESTES guidelines: acute mesenteric ischaemia
Tilsed, J. V. T., Casamassima, A., Kurihara, H., Mariani, D., Martinez, I., Pereira, J., Ponchietti, L., Shamiyeh, A., al-Ayoubi, F., Barco, L. A. B., et al. (2016) · European Journal of Trauma and Emergency Surgery · doi:10.1007/s00068-016-0634-0 · Cited by 382
Pawlik, T. M., Reyes, D. K., Cosgrove, D., Kamel, I. R., Bhagat, N., & Geschwind, J.-F. H. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.37.1021 · Cited by 304
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Metadata
- Venue
- Hepatogastroenterology
- Publisher
- Update Medical Publishing
- Published
- 2011-10-24
- Volume
- 59
- Issue
- 115
- Pages
- 785-9
- ISSN
- 0172-6390 (ISSN-L)
- OpenAlex
- W142591619
- Cited by
- 953
- References
- 0
- Type
- paratext
- Language
- en
- Open access
- closed
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