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In vivo Spectroscopy and Imaging of Nitroxide Probes
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Book chapter from "Nitroxides - Theory, Experiment and Applications", edited by Alexander I. Kokorin, ISBN 978-953-51-0722-4, Hard cover, 436 pages, InTech, September 12, 2012.\nDOI: 10.5772/2887
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EPR oximetry is a relatively simple, non-invasive method to measure oxygen levels in biological systems using implanted and soluble paramagnetic probes.
“EPR oximetry is a relatively simple, non-invasive method to measure oxygen levels in biological systems using implanted and soluble paramagnetic probes, the use of which has been gradually increasing [27–30].”
From Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry (2016) · cites this paper as [27]
Section 2.1 describes EPR oximetry as a basis for non-invasive oxygen measurement in biological systems and identifies both implantable particulate probes and soluble probes. It also calls the technique rapidly developing, but does not characterize it as relatively simple. (LLM, conf=0.85)
Experimental — accuracy not yet measuredOne advantage of EPR-based methodology over micro-electrode measurements is that linewidth of spectra is based on pure physical interaction between paramagnetic probe molecules and oxygen within the biological system.
“One advantage which EPR based methodology has over normal micro-electrode measurements is that linewidth of spectra is based on pure physical interaction between paramagnetic probe molecules and oxygen within the biological system [27].”
From Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry (2016) · cites this paper as [27]
Section 2.1 (page not available) says EPR oximetry relies on a physical interaction between paramagnetic probes and oxygen, and describes oxygen-induced spectral broadening. It does not compare this advantage with micro-electrode measurements, so that comparative part is not supported by our copy. (LLM, conf=0.84)
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2 of the 132 references couldn’t be matched to a known paper.
Cited by
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Metadata
- Authors
- V., V.
- Venue
- Nitroxides - Theory, Experiment and Applications
- Publisher
- InTech
- Published
- 2012-09-12
- OpenAlex
- W1534222630
- Cited by
- 8
- References
- 132
- Citations by year
- 2025: 2 · 2021: 1 · 2020: 2 · 2017: 1 · 2016: 2
- FWCI
- 0.00
- Type
- book chapter
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- InTech eBooks (publishedVersion, cc-by)
- BiblioBoard Library Catalog (Open Research Library) (submittedVersion, cc-by)
- Contact-less Assessment of In-vivo Body Signals Using Microwave Doppler Radar (InTech) (submittedVersion, cc-by)
- The Knowledge Bank (The Ohio State University) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (EB014542)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Electron Spin Resonance Studies
- Physical Sciences › Chemistry › Spectroscopy › Advanced NMR Techniques and Applications
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Magnetism in coordination complexes
- Keywords
- nitroxide probes, in vivo spectroscopy, in vivo imaging, nitroxide radicals, spin-labeled probes, magnetic resonance imaging
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