Cited by 186Nanoparticles: synthesis and applicationsTiO2 Photocatalysis and Solar CellsAntimicrobial agents and applications

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Antimicrobial Effect of Titanium Dioxide Nanoparticles

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López de Dicastillo, Carol, Guerrero Correa, Matias, B. Martínez, Fernanda, Streitt, Camilo, José Galotto, Maria·2021·Antimicrobial Resistance - A One Health Perspective

DOI 10.5772/intechopen.90891

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Abstract

The widespread use of antibiotics has led to the emergence of multidrug-resistant bacterial strains, and therefore a current concern for food safety and human health. The interest for new antimicrobial substances has been focused toward metal oxide nanoparticles. Specifically, titanium dioxide (TiO2) has been considered as an attractive antimicrobial compound due to its photocatalytic nature and because it is a chemically stable, non-toxic, inexpensive, and Generally Recognized as Safe (GRAS) substance. Several studies have revealed this metal oxide demonstrates excellent antifungal and antibacterial properties against a broad range of both Gram-positive and Gram-negative bacteria. These properties were significantly improved by titanium dioxide nanoparticles (TiO2 NPs) synthesis. In this chapter, latest developments on routes of synthesis of TiO2 NPs and antimicrobial activity of these nanostructures are presented. Furthermore, TiO2 NPs favor the inactivation of microorganisms due to their strong oxidizing power by free radical generation, such as hydroxyl and superoxide anion radicals, showing reductions growth against several microorganisms, such as Escherichia coli and Staphylococcus aureus. Understanding the main mechanisms of antimicrobial action of these nanoparticles was the second main purpose of this chapter.

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Authors: López de Dicastillo, C., Guerrero Correa, M., B. Martínez, F., Streitt, C., & José Galotto, M.
Affiliations: Universidad de Santiago de Chile (CL)
Venue: Antimicrobial Resistance - A One Health Perspective
Publisher: IntechOpen
Published: 2021-03-03
DOI: 10.5772/intechopen.90891
OpenAlex: W3004027969
Cited by: 159
References: 81
Citations by year: 2026: 7 · 2025: 17 · 2024: 27 · 2023: 34 · 2022: 38 · 2021: 31
FWCI: 47.89
Type: book chapter
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/legalcode (unspecified)
Locations: IntechOpen eBooks (publishedVersion, cc-by)
BiblioBoard Library Catalog (Open Research Library) (submittedVersion, cc-by)
Contact-less Assessment of In-vivo Body Signals Using Microwave Doppler Radar (InTech) (submittedVersion, cc-by)
Funders: Corporación de Fomento de la Producción
Comisión Nacional de Investigación Científica y Tecnológica (Fondecyt Regular 1170624, FB0807, Project FB0807)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › TiO2 Photocatalysis and Solar Cells
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
Keywords: titanium dioxide nanoparticles, antimicrobial activity, photocatalysis, metal oxide nanoparticles, nanoparticle synthesis, free radical generation, hydroxyl radicals, superoxide, antibacterial activity, antifungal activity, antibiotic resistance, Escherichia coli, Staphylococcus aureus, antimicrobial mechanisms

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