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Antimicrobial Effect of Titanium Dioxide Nanoparticles
Open accessAbstract
The widespread use of antibiotics has led to the emergence of multidrug-resistant bacterial strains, and therefore a current concern for food safety and human health. The interest for new antimicrobial substances has been focused toward metal oxide nanoparticles. Specifically, titanium dioxide (TiO2) has been considered as an attractive antimicrobial compound due to its photocatalytic nature and because it is a chemically stable, non-toxic, inexpensive, and Generally Recognized as Safe (GRAS) substance. Several studies have revealed this metal oxide demonstrates excellent antifungal and antibacterial properties against a broad range of both Gram-positive and Gram-negative bacteria. These properties were significantly improved by titanium dioxide nanoparticles (TiO2 NPs) synthesis. In this chapter, latest developments on routes of synthesis of TiO2 NPs and antimicrobial activity of these nanostructures are presented. Furthermore, TiO2 NPs favor the inactivation of microorganisms due to their strong oxidizing power by free radical generation, such as hydroxyl and superoxide anion radicals, showing reductions growth against several microorganisms, such as Escherichia coli and Staphylococcus aureus. Understanding the main mechanisms of antimicrobial action of these nanoparticles was the second main purpose of this chapter.
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“The crystalline structure and the shape of TiO2 NPs are both considered as the most important conditions that affect its physicochemical factors and therefore its antimicrobial activity [38].”
From Antibacterial Activity of TiO2 Nanoparticles Prepared by One-Step Laser Ablation in Liquid (2021) · cites this paper as [38]
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Metadata
- Authors
- López de Dicastillo, C., Guerrero Correa, M., B. Martínez, F., Streitt, C., & José Galotto, M.
- Affiliations
- Universidad de Santiago de Chile (CL)
- Venue
- Antimicrobial Resistance - A One Health Perspective
- Publisher
- IntechOpen
- Published
- 2021-03-03
- OpenAlex
- W3004027969
- Cited by
- 159
- References
- 81
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 27 · 2023: 34 · 2022: 38 · 2021: 31
- FWCI
- 47.89
- Type
- book chapter
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- IntechOpen eBooks (publishedVersion, cc-by)
- BiblioBoard Library Catalog (Open Research Library) (submittedVersion, cc-by)
- Contact-less Assessment of In-vivo Body Signals Using Microwave Doppler Radar (InTech) (submittedVersion, cc-by)
- Funders
- Corporación de Fomento de la Producción
- Comisión Nacional de Investigación Científica y Tecnológica (Fondecyt Regular 1170624, FB0807, Project FB0807)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › TiO2 Photocatalysis and Solar Cells
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Keywords
- titanium dioxide nanoparticles, antimicrobial activity, photocatalysis, metal oxide nanoparticles, nanoparticle synthesis, free radical generation, hydroxyl radicals, superoxide, antibacterial activity, antifungal activity, antibiotic resistance, Escherichia coli, Staphylococcus aureus, antimicrobial mechanisms
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