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Tetralogy of Fallot in the nascent open-heart surgical era in a tertiary hospital in south-west Nigeria: lessons learnt
Open accessAbstract
BACKGROUND: Tetralogy of Fallot (TOF) is the leading cyanotic congenital heart disease. We commenced open-heart surgery at the Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Nigeria in 2016. OBJECTIVES: To review the incidence, pattern, management and treatment outcomes of TOF at the OAUTHC. METHODS: A retrospective audit was undertaken of hospital records, including echocardiograms of patients with TOF seen from January 2016 to February 2020 at the Paediatric Cardiology Unit, OAUTHC. RESULTS: Seventy-two patients (37 boys and 35 girls) aged 0.17-22 years had TOF. Thirty-three (45.8%) had surgery; 31 (93.9%) corrective surgery and two (6.1%) a modified Blalock-Taussig shunt. Complications following surgery included cardiac dysfunction, post-transfusion malaria, pulmonary regurgitation, pericardial effusion and death (15%). Thirty-nine (54.2%) patients had conservative medical management. Complications included polycythaemia and thrombotic stroke, and 14 (35.9%) patients died. CONCLUSIONS: TOF is associated with significant morbidity and mortality in developing countries. Early and safe corrective surgery is desirable.
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“Preoperative cerebral complications occur in as many as 20% of cases in patients with a delayed diagnosis, while being rare in HICs.17, 21, 22”
From Tetralogy of Fallot in Low- and Middle-Income Countries (2024) · cites this paper as [21]
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“Patients from LMICs exhibited a higher number of symptoms due to prolonged hypoxic exposure.”
From Tetralogy of Fallot in Low- and Middle-Income Countries (2024) · cites this paper as [21]
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“Indeed, the limited data from LMICs suggest that the mean age of repair is instead between 4.7 and 21 years.”
From Tetralogy of Fallot in Low- and Middle-Income Countries (2024) · cites this paper as [21]
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“Based on our humanitarian experience (with Ste-Justine au Coeur du Monde for almost 20 years with missions in Morocco, Senegal, Ethiopia, South Africa, and Egypt), these metrics are more representative of the reality in LMICs.13,17, 21, 22”
From Tetralogy of Fallot in Low- and Middle-Income Countries (2024) · cites this paper as [21]
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“Indeed, more than half of the patients experienced dyspnea, syncope, chest pain, and seizures.12,13,17, 21, 22, 23”
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“In fact, this complication affects up to 60% of patients.21”
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Cited by
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Tetralogy of Fallot in Low- and Middle-Income Countries
Dib, N., Chauvette, V., Diop, M. S., Bouhout, I., Hadid, M., Vô, C., Khairy, P., & Poirier, N. (2024) · CJC Pediatric and Congenital Heart Disease · doi:10.1016/j.cjcpc.2023.12.002 · Cited by 19
“13,17,21,22 This delay in treatment has several impacts.”
BackgroundInfluential
Metadata
- Authors
- Bamigboye-Taiwo, O. T., Adeyefa, B., Onakpoya, U. U., Ojo, O. O., Eyekpegha, J. O., Oguns, A., & Okeniyi, J. A.
- Affiliations
- Obafemi Awolowo University Teaching Hospitals Complex (NG)
- Venue
- Cardiovascular Journal of Africa
- Publisher
- Clinics Cardive Publishing
- Published
- 2022-07-11
- Volume
- 33
- Issue
- 3
- Pages
- 24-29
- ISSN
- 1015-9657 (ISSN-L)
- 1995-1892
- 1680-0745
- PMC
- PMC9540326
- OpenAlex
- W3217521958
- Cited by
- 6
- References
- 0
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Cardiovascular Conditions and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- tetralogy of Fallot, cyanotic congenital heart disease, open heart surgery, surgical outcomes, postoperative complications, conservative medical management, Blalock-Taussig shunt, mortality, polycythemia, thrombotic stroke, developing countries, Southwest Nigeria
- MeSH terms
- Child, Female, Humans, Infant, Male, Nigeria, Retrospective Studies, Tetralogy of Fallot, Treatment Outcome, Blalock-Taussig Procedure, Tertiary Care Centers
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