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Cited by 1,042

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer (Unabridged Version)

Hammond, M. Elizabeth H., Hayes, Daniel F., Dowsett, Mitch, Allred, D. Craig, Hagerty, Karen L., Badve, Sunil, Fitzgibbons, Patrick L., Francis, Glenn, Goldstein, Neil S., Hayes, Malcolm, Hicks, David G., Lester, Susan, Love, Richard, Mangu, Pamela B., McShane, Lisa, Miller, Keith, Osborne, C. Kent, Paik, Soonmyung, Perlmutter, Jane, Rhodes, Anthony, Sasano, Hironobu, Schwartz, Jared N., Sweep, Fred C. G., Taube, Sheila, Torlakovic, Emina Emilia, Valenstein, Paul, Viale, Giuseppe, Visscher, Daniel, Wheeler, Thomas, Williams, R. Bruce, Wittliff, James L., Wolff, Antonio C.·2010·Archives of Pathology & Laboratory Medicine
DOI 10.5858/134.7.e48
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Abstract

Purpose. —To develop a guideline to improve the accuracy of immunohistochemical (IHC) estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer and the utility of these receptors as predictive markers. Methods. —The American Society of Clinical Oncology and the College of American Pathologists convened an international Expert Panel that conducted a systematic review and evaluation of the literature in partnership with Cancer Care Ontario and developed recommendations for optimal IHC ER/PgR testing performance. Results. —Up to 20% of current IHC determinations of ER and PgR testing worldwide may be inaccurate (false negative or false positive). Most of the issues with testing have occurred because of variation in pre-analytic variables, thresholds for positivity, and interpretation criteria. Recommendations. —The Panel recommends that ER and PgR status be determined on all invasive breast cancers and breast cancer recurrences. A testing algorithm that relies on accurate, reproducible assay performance is proposed. Elements to reliably reduce assay variation are specified. It is recommended that ER and PgR assays be considered positive if there are at least 1% positive tumor nuclei in the sample on testing in the presence of expected reactivity of internal (normal epithelial elements) and external controls. The absence of benefit from endocrine therapy for women with ER-negative invasive breast cancers has been confirmed in large overviews of randomized clinical trials.

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Metadata

Authors
Hammond, M. E. H., Hayes, D. F., Dowsett, M., Allred, D. C., Hagerty, K. L., Badve, S., Fitzgibbons, P. L., Francis, G., Goldstein, N. S., Hayes, M., Hicks, D. G., Lester, S., Love, R., Mangu, P. B., McShane, L., Miller, K., Osborne, C. K., Paik, S., Perlmutter, J., Rhodes, A., Sasano, H., Schwartz, J. N., Sweep, F. C. G., Taube, S., Torlakovic, E. E., Valenstein, P., Viale, G., Visscher, D., Wheeler, T., Williams, R. B., Wittliff, J. L., & Wolff, A. C.
Venue
Archives of Pathology & Laboratory Medicine
Publisher
Archives of Pathology and Laboratory Medicine
Published
2010-07
Volume
134
Issue
7
Pages
e48-e72
ISSN
  • 0003-9985 (ISSN-L)
  • 1543-2165
DOI
10.5858/134.7.e48
OpenAlex
W4234081105
Cited by
1,042
References
58
FWCI
11.92
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer (Unabridged Version). https://app.cochat.ai/papers/10.5858/134.7.e48
The paper
Hammond, M. E. H., Hayes, D. F., Dowsett, M., Allred, D. C., Hagerty, K. L., Badve, S., Fitzgibbons, P. L., Francis, G., Goldstein, N. S., Hayes, M., Hicks, D. G., Lester, S., Love, R., Mangu, P. B., McShane, L., Miller, K., Osborne, C. K., Paik, S., Perlmutter, J., . . . Wolff, A. C. (2010). American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer (Unabridged Version). Archives of Pathology & Laboratory Medicine. https://doi.org/10.5858/134.7.e48

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.