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Cited by 7Hair Growth and DisordersMedicinal Plant ResearchMedicinal Plant Pharmacodynamics Research

Effect of ethanol extract of plant mixture on hair regeneration in human dermal papilla cells and C57BL/6J mice

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Bo, Huang, Bueom Goo, Kang, Zhiqiang, Wang, Soon, Sung Lim·2015·Journal of Medicinal Plants Research
DOI 10.5897/jmpr2014.5355
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Abstract

This study determined the effect of 30% ethanol extract of plant mixture (EPM: Glycyrrhiza uralensis, Angelica gigas, Acorus calamus, Cnidium officinale, Panax ginseng, Camellia sinensis, Salvia miltiorrhiza, Zanthoxylum schinifolium, Carthamus tinctorius, Prunus persica and Scrophularia buergeriana) on promotion of hair growth in human hair dermal papilla cells and C57BL/6J mice. EPM significantly increased the proliferation of human hair dermal papilla cells in a dose- and time- dependent manner (p < 0.05 and p < 0.01). EPM also enhanced mRNA and protein levels of growth factors such as IGF-1, VEGF, KGF and HGF. Moreover, photographical and histological observation showed that application of EPM resulted in the early onset and prolongation of the anagen phase of the hair cycle. In addition, the EPM was revealed to possess potent inhibitory effect on the 5α-reductase activity. Taken together, these results suggest that EPM has hair growth promoting potential and can be used for hair growing products. Key words: Hair growth, extract of plant mixture, growth factors, steroid 5α-reductase.

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Cited by

Sorted by citations

Authors
Bo, H., Bueom Goo, K., Zhiqiang, W., & Soon, S. L.
Affiliations
Hallym University (KR)
Venue
Journal of Medicinal Plants Research
Publisher
Academic Journals
Published
2015-12-03
Volume
9
Issue
45
Pages
1103-1110
ISSN
1996-0875 (ISSN-L)
DOI
10.5897/jmpr2014.5355
OpenAlex
W2561955380
Cited by
7
References
0
Citations by year
2024: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 1
FWCI
0.43
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
Journal of Medicinal Plants Research (publishedVersion, cc-by)
Funders
  • National Research Foundation
  • National Research Foundation of Korea (NRF-2012R1A1A2008842, 2009-0094071, NRF-2009-0094071)
  • Ministry of Education, Science and Technology (NRF-2009-0094071)
Topics
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Medicinal Plant Pharmacodynamics Research
Keywords
hair growth promotion, hair regrowth, dermal papilla cells, plant extracts, ethanol extract, Glycyrrhiza uralensis, Angelica gigas, Panax ginseng, Salvia miltiorrhiza, 5α-reductase inhibition, anagen phase, growth factors, insulin-like growth factor I, vascular endothelial growth factor, keratinocyte growth factor, hepatocyte growth factor, hair growth products

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