SYNTHESIS AND EVALUATION OF OCTOCRYLENE-INSPIRED COMPOUNDS FOR UV-FILTER ACTIVITY
Open accessAbstract
Octocrylene (2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate) is present in several sunscreens and is known to work synergistically with UV filters. We prepared eight octocrylene-related compounds to test their photoprotective activities by measuring diffuse transmittance. The compounds had varied photoprotection profiles, with Sun Protection Factors (SPF) ranging from 1 to 5 and UVA Protection Factors (UVAPF) ranging from 1 to 8. Compounds 4, 5, and 7 showed the best protection against UVB sunrays, while compounds 5, 6, and 7 presented the best results for protection from UVA, so compound 7 had the most balanced protection overall. Results for compounds 4, 8, and 9 are reported for the first time in the literature.
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Among eight octocrylene (30)-related compounds (57-64), compounds 60, 61, and 63 displayed the best UVB protection effect, while compounds 61-63 presented the best results concerning protection against UVA.
“Among these, 60, 61, and 63 displayed the best UVB protection effect, while compounds 61–63 presented the best results concerning protection against UVA.”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [130]
Compound 63 was the most promising octocrylene-related derivative and behaved as a broad band UVA/UVB filter.
“The most promising derivative was 63, which behaved as a broad band UVA/UVB filter [130].”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [130]
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- Authors
- Polonini, H. C., Lopes, R. S., Beatriz, A., Gomes, R. S., Silva, A. O., Lima, R. V. D., Nunes, G. A., Brandão, M. A. F., Raposo, N. R. B., & Lima, D. P. D.
- Affiliations
- Universidade Federal de Juiz de Fora (BR)
- Universidade Federal de Mato Grosso do Sul (BR)
- ORCID
- Venue
- Química Nova
- Publisher
- GN1 Sistemas e Publicacoes Ltd.
- Published
- 2014
- ISSN
- 0100-4042 (ISSN-L)
- OpenAlex
- W2120005379
- Cited by
- 27
- References
- 1
- Citations by year
- 2025: 1 · 2024: 3 · 2022: 4 · 2021: 13 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Química Nova (publishedVersion, cc-by-nc)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Universidade Federal de Juiz de Fora
- Universidade Federal de Mato Grosso do Sul
- Pró-Reitoria de Pesquisa, Universidade Federal do Rio Grande do Sul
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Materials Science › Materials Chemistry › Photochromic and Fluorescence Chemistry
- Physical Sciences › Chemistry › Organic Chemistry › Photopolymerization techniques and applications
- Keywords
- octocrylene, UV filters, photoprotection, UVB protection, UVA protection, sun protection factor, UVA protection factor, diffuse transmittance
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