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Cited by 17

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Association of salivary steroid hormones and their ratios with time-domain heart rate variability indices in healthy individuals

Mazgelytė, Eglė, Chomentauskas, Gintaras, Dereškevičiūtė, Edita, Rekienė, Virginija, Jakaitienė, Audronė, Petrėnas, Tomas, Songailienė, Jurgita, Utkus, Algirdas, Aušrelė, Kučinskienė, Karčiauskaitė, Dovilė·2021·Journal of Medical Biochemistry
DOI 10.5937/jomb0-26045
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Abstract

Background: Stress system consists of the hypothalamicpituitary-adrenal (HPA) axis and the locus caeruleus/norepinephrine-autonomic nervous system (ANS). Traditionally, HPA axis activity is evaluated by measuring its end-product cortisol, while the activity of ANS is assessed using heart rate variability (HRV) indices. Alterations in cortisol levels and HRV measures during laboratory-based stress tasks were extensively studied in previous research. However, scarce data exist on the associations of HRV measures with the levels of other adrenal steroid hormones under baseline conditions. Thus, we aimed to evaluate the activity of the HPA axis by measuring salivary cortisol, cortisone, dehydroepiandrosterone (DHEA) levels, and their ratios and to examine its association with HRV measures in a sample of healthy young and middle-aged adults. Methods: For each participant (n = 40), three data collection sessions taking place at the same time of the day were scheduled within five working days. Participants completed a self-reported questionnaire on sociodemographic and lifestyle characteristics, filled out t h e Perceived Stress Scale and State-Trait Anxiety Inventory. Also, saliva samples were collected, and physiological measures, including resting HR and HRV, were recorded during three data collection sessions. Results: Statistically significant associations between diminished parasympathetic vagal tone evaluated by time domain HRV measures and higher salivary cortisol, lower DHEA levels, as well as decreased DHEA to cortisol ratio, were found. Also, physiological stress indicators (i.e., HRV) showed greater intraindividual stability compared with biochemical biomarkers (i.e., salivary steroid hormones) within five days. Conclusions: Our findings suggest that both cortisol and DHEA mediate the link between two stress-sensitive homeostatic systems.

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Research works printed but not linked: 23

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Cited by

Metadata

Authors
Mazgelytė, E., Chomentauskas, G., Dereškevičiūtė, E., Rekienė, V., Jakaitienė, A., Petrėnas, T., Songailienė, J., Utkus, A., Aušrelė, K., & Karčiauskaitė, D.
Venue
Journal of Medical Biochemistry
Publisher
Centre for Evaluation in Education and Science (CEON/CEES)
Published
2021
Volume
40
Issue
2
Pages
173-180
ISSN
  • 1452-8258
  • 1452-8266
DOI
10.5937/jomb0-26045
Cited by
17
References
3
Language
en
Licence
creativecommons.org/licenses/BY/4.0 (unspecified)

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