Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Red blood cell adaptations induced by exercise

Stefanović, Radoš, Ristić, Biljana, Drvenica, Ivana·2024·Srpski medicinski casopis Lekarske komore
DOI 10.5937/smclk5-51250
Open this paper in CoChat — free account

Abstract

Exercise significantly increases blood flow and perfusion in active muscles to enhance oxygen and nutrient delivery. These enhanced demands affect blood rheology and red blood cell (RBC) characteristics, leading to specific adaptations. These adaptations are influenced by exercise type, intensity, frequency, duration, and individual characteristics of subject population (gender, age, nutritional status etc.). This review aims to comprehensively summarize the different adaptations of erythrocytes to short-term and long-term exercise, as well as the mechanisms of their occurrence, considering the influence of various factors. The results from the previous research indicate that regular exercise enhances the metabolic, structural, and functional capabilities of RBCs. These adaptations include improved energy balance, increased cell turnover rate, improved membrane stability, as well as better antioxidative defense. Despite potential risks such as "sports anemia", exercise also affects the dynamics of hemoglobin and iron concentrations, as well as the appearance of extracellular hemoglobin. Overall , the literature highlights the critical role of exercise in maintaining optimal erythrocyte function, improving circulation, and overall health, offering potential therapeutic benefits. Through a critical review of literature data on the influence of exercise on the characteristics and functions of erythrocytes, this paper can be a useful guideline for the interpretation of clinically significant results in physically active individuals .

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.5937/smclk5-51250

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 2 references

Research works printed but not linked: 55

  1. Cho YI, Mooney MP, Cho DJ. Hemorheological disorders in diabetes mellitus. J Diabetes Sci Technol. 2008;2(6):1130-8. doi: 10.1177/1932296808002006; · DOI
  2. Lippi G, Sanchis-Gomar F. Epidemiological, biological and clinical update on exercise-induced hemolysis. Ann Transl Med. 2019;7(12). doi: 10.21037/ atm.2019.05.41; · DOI · Paper page
  3. Paraiso LF, Gonçalves-e-Oliveira AFM, Cunha LM, de Almeida Neto OP, Pacheco AG, Araújo KBG, et al. Effects of acute and chronic exercise on the osmotic stability of erythrocyte membrane of competitive swimmers. PLoS One. 2017;12(2):e0171318. doi: 10.1371/journal.pone.0171318; · DOI · Paper page
  4. Pospieszna B, Kusy K, Slominska EM, Zieliński J. Life-long sports engagement enhances adult erythrocyte adenylate energetics. Sci Rep. 2021;11(1):23759. doi: 10.1038/s41598-021-03275-y; · DOI
  5. Van Wijk R, Van Solinge WW. The energy-less red blood cell is lost: erythrocyte enzyme abnormalities of glycolysis. Blood. 2005;106(13):4034-42. doi: 10.1182/blood-2005-04-1622; · DOI · Paper page
  6. De la Fuente IM, Cortés JM, Valero E, Desroches M, Rodrigues S, Malaina I, et al. On the dynamics of the adenylate energy system: homeorhesis vs homeostasis. PLoS One. 2014;9(10):e108676. doi: 10.1371/journal.pone.0108676; · DOI
  7. Dudzinska W, Suska M, Lubkowska A, Jakubowska K, Olszewska M, Safranow K, et al. Comparison of human erythrocyte purine nucleotide metabolism and blood purine and pyrimidine degradation product concentrations before and after acute exercise in trained and sedentary subjects. J Physiol Sci. 2018;68:293-305. doi: 10.1007/s12576-017-0536-x; · DOI
  8. Pospieszna B, Kusy K, Słomińska EM, Dudzinska W, Ciekot-Sołtysiak M, Zieliński J. The effect of training on erythrocyte energy status and plasma purine metabolites in athletes. Metabolites. 2019;10(1):5. doi: 10.3390/metabo10010005; · DOI
  9. Racine ML, Dinenno FA. Reduced deformability contributes to impaired deoxygenation-induced ATP release from red blood cells of older adult humans. J Physiol. 2019;597(17):4503-19. doi: 10.1113/JP278338; · DOI
  10. Dudzinska W. Purine nucleotides and their metabolites in patients with type 1 and 2 diabetes mellitus. J Biomed Sci Eng. 2014;7(1):38-44. doi: 10.4236/ jbise.2014.71006; · DOI
  11. O'Brien III WG, Berka V, Tsai A-L, Zhao Z, Lee CC. CD73 and AMPD3 deficiency enhance metabolic performance via erythrocyte ATP that decreases hemoglobin oxygen affinity. Sci Rep. 2015;5(1):13147. doi: 10.1038/srep13147; · DOI · Paper page
  12. Smith JA. Exercise, training and red blood cell turnover. Sports Med. 1995;19(1):9-31. doi: 10.2165/00007256-199519010-00002; · DOI
  13. Lew VL, Tiffert T. On the mechanism of human red blood cell longevity: roles of calcium, the sodium pump, PIEZO1, and gardos channels. Front Physiol. 2017;8:977. doi: 10.3389/fphys.2017.00977; · DOI
  14. Ingley E. Erythrocytes. Encyclopedia of Respiratory Medicine, Second Edition: Erythrocytes: Elsevier; 2022. p. 232-7; · DOI
  15. Sentürk UK, Gündüz F, Kuru O, Koçer G, Ozkaya YG, Yesilkaya A, et al. Exercise-induced oxidative stress leads hemolysis in sedentary but not trained humans. J Appl Physiol (1985). 2005;99(4):1434-41. doi: doi. org/ 10. 1152/ jappl physi ol. 01392. 2004; · DOI
  16. Weight LM, Byrne MJ, Jacobs P. Haemolytic effects of exercise. Clin Sci (Lond). 1991;81(2):147-52. doi: 10.1042/cs0810147; · DOI
  17. Smith JA, Martin DT, Telford RD, Ballas SK. Greater erythrocyte deformability in world-class endurance athletes. Am J Physiol. 1999;276(6):H2188-93. doi: 10.1152/ajpheart.1999.276.6.H2188; · DOI
  18. Schobersberger W, Tschann M, Hasibeder W, Steidl M, Herold M, Nachbauer W, et al. Consequences of 6 weeks of strength training on red cell O 2 transport and iron status. Eur J Appl Physiol Occup Physiol. 1990;60:163-8. doi: 10.1007/BF00839152; · DOI
  19. Robinson Y, Cristancho E, Böning D. Intravascular hemolysis and mean red blood cell age in athletes. Med Sci Sports Exerc. 2006;38(3):480-3. doi: 10.1249/01.mss.0000188448.40218.4c; · DOI
  20. Falsetti HL, Burke ER, Feld RD, Frederick EC, Ratering C. Hematological variations after endurance running with hard-and soft-soled running shoes. Phys Sportsmed. 1983;11(8):118-27. doi: 10.1080/00913847.1983.11708609; · DOI
  21. Telford RD, Sly GJ, Hahn AG, Cunningham RB, Bryant C, Smith JA. Footstrike is the major cause of hemolysis during running. J Appl Physiol (1985). 2003;94(1):38-42. doi: 10.1152/japplphysiol.00631.2001; · DOI · Paper page
  22. Selby GB, Eichner ER. Endurance swimming, intravascular hemolysis, anemia, and iron depletion: new perspective on athlete's anemia. Am J Med. 1986;81(5):791-4. doi: 10.1016/0002-9343(86)90347-5; · DOI · Paper page
  23. Beneke R, Bihn D, Hütler M, Leithäuser RM. Haemolysis caused by alterations of a-and b-spectrin after 10 to 35 min of severe exercise. Eur J Appl Physiol. 2005;95:307-12. doi: 10.1007/s00421-005-0010-y; · DOI
  24. Drvenica IT, Stančic'AZStančic'AZ, Maslovaric'ISMaslovaric'IS, Trivanovic'DITrivanovic'DI, Ilic'VLIlic'VL. Extracellular hemoglobin: modulation of cellular functions and pathophysiological effects. Biomolecules. 2022;12(11):1708. doi: 10.3390/biom12111708; · DOI
  25. Stančic'AStančic'A, Drvenica I, Bugarski B, Ilic'VIlic'V, Bugarski D. Extracellular xenogeneic hemoglobin suppresses the capacity for C2C12 myoblast myogenic differentiation. Arch Biol Sci. 2020;72(3):379-91. doi: doi.org/10.2298/ ABS200625032S; · DOI · Paper page
  26. Richieri GV, Mel HC. Temperature effects on osmotic fragility, and the erythrocyte membrane. Biochim Biophys Acta. 1985;813(1):41-50. doi: 10.1016/0005-2736(85)90343-8; · DOI
  27. Hiro T. Studies on the osmotic fragility of erythrocytes influenced by a metabolic acidosis. Jap J Phys Fitness Sports Med. 1982;31(5):279-90. doi: 10.7600/jspfsm1949.31.279; · DOI
  28. Platt OS, Lux SE, Nathan DG. Exercise-induced hemolysis in xerocytosis. Erythrocyte dehydration and shear sensitivity. J Clin Invest. 1981;68(3):631-8. doi: 10.1172/JCI110297; · DOI
  29. Rasmussen H, Lake W, Allen JE. The effect of catecholamines and prostaglandins upon human and rat erythrocytes. Biochim Biophys Acta. 1975;411(1):63-73. doi: 10.1016/0304-4165(75)90285-8; · DOI
  30. Yusof A, Leithauser RM, Roth HJ, Finkernagel H, Wilson MT, Beneke R. Exercise-induced hemolysis is caused by protein modification and most evident during the early phase of an ultraendurance race. J Appl Physiol (1985). 102(2):582-6. doi: 10.1152/japplphysiol.00580.2006; · DOI
  31. Vitali EDP, Guglielmini C, Casoni I, Vedovato M, Gilli P, Farinelli A, et al. Serum erythropoietin in cross-country skiers. Int J Sports Med. 1988;9(2):99-101. doi: 10.1055/s-2007-1024986; · DOI
  32. Montero D, Breenfeldt-Andersen A, Oberholzer L, Haider T, Goetze JP, Meinild-Lundby A-K, et al. Erythropoiesis with endurance training: dynamics and mechanisms. Am J Physiol Regul Integr Comp Physiol. 2017;312(6):R894-R902. doi: 10.1152/ajpregu.00012.2017; · DOI
  33. Caldemeyer KS, Smith RR, Harris A, Williams T, Huang Y, Eckert GJ, et al. Hematopoietic bone marrow hyperplasia: correlation of spinal MR findings, hematologic parameters, and bone mineral density in endurance athletes. Radiology. 1996;198(2):503-8. doi: 10.1148/radiology.198.2.8596857; · DOI
  34. Shellock FG, Morris E, Deutsch AL, Mink JH, Kerr R, Boden SD. Hematopoietic bone marrow hyperplasia: high prevalence on MR images of the knee in asymptomatic marathon runners. AJR Am J Roentgenol. 1992;158(2):335-8. doi: 10.2214/ajr.158.2.1729795; · DOI
  35. Altehoefer C, Schmid A, Büchert M, Ghanem NA, Heinrich L, Langer M. Characterization of hematopoietic bone marrow in male professional cyclists by magnetic resonance imaging of the lumbar spine. J Magn Reson Imaging.2002;16(3):284-8. doi: 10.1002/jmri.10157; · DOI
  36. Trivanovic'DITrivanovic'DI, Drvenica IT. Bone marrow adipose tissue: impacts on bone marrow stem cell niche and hematopoietic system. Reference Module in Biomedical Sciences: Elsevier; 2024. doi: 10.1016/B978-0-443-15717-2.00096-2; · DOI
  37. Dar A, Schajnovitz A, Lapid K, Kalinkovich A, Itkin T, Ludin A, et al. Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells. Leukemia. 2011;25(8):1286-96. doi: 10.1038/leu.2011.62; · DOI
  38. Christ ER, Cummings MH, Westwood NB, Sawyer BM, Pearson TC, Sönksen PH, et al. The importance of growth hormone in the regulation of erythropoiesis, red cell mass, and plasma volume in adults with growth hormone deficiency. J Clin Endocrinol Metab. 1997;82(9):2985-90. doi: 10.1210/ jcem.82.9.4199; · DOI
  39. Ambroży T, Rydzik Ł, Obmiński Z, Błach W, Serafin N, Błach B, et al. The effect of high-intensity interval training periods on morning serum testosterone and cortisol levels and physical fitness in men aged 35-40 years. J Clin Med. 2021;10(10):2143. doi: 10.3390/jcm10102143; · DOI
  40. Petraglia F, Barletta C, Facchinetti F, Spinazzola F, Monzani A, Scavo D, et al. Response of circulating adrenocorticotropin, beta-endorphin, beta-lipotropin and cortisol to athletic competition. Acta Endocrinol (Copenh). 1988;118(3):332-6. doi: 10.1530/acta.0.1180332; · DOI
  41. Schwarz AJ, Brasel JA, Hintz RL, Mohan S, Cooper DM. Acute effect of brief low-and high-intensity exercise on circulating insulin-like growth factor (IGF) I, II, and IGF-binding protein-3 and its proteolysis in young healthy men. J Clin Endocrinol Metab. 1996;81(10):3492-7. doi: 10.1210/ jcem.81.10.8855791; · DOI · Paper page
  42. Bernardino Neto M, de Avelar EB Jr, Arantes TS, Jordão IA, da Costa Huss JC, de Souza TM, et al. Bivariate and multivariate analyses of the correlations between stability of the erythrocyte membrane, serum lipids and hematological variables. Biorheology. 2013;50(5-6):305-20. doi: 10.3233/BIR-130641; · DOI
  43. Lemos GSD, Márquez-Bernardes LF, Arvelos LR, Paraíso LF, Penha-Silva N. Influence of glucose concentration on the membrane stability of human erythrocytes. Cell Biochem Biophys. 2011;61(3):531-7. doi: 10.1007/s12013-011-9235-z; · DOI
  44. de Freitas MV, Marquez-Bernardes LF, de Arvelos LR, Paraíso LF, Gonçalves E Oliveira AFM, Mascarenhas Netto Rde C, et al. Influence of age on the correlations of hematological and biochemical variables with the stability of erythrocyte membrane in relation to sodium dodecyl sulfate. Hematology. 2014;19(7):424-30. doi: 10.1179/1607845413Y.0000000145; · DOI
  45. Drvenica I, Mojsilovic'SMojsilovic'S, Stančic'AStančic'A, Markovic'DMarkovic'D, Kovačic'MKovačic'M, Maslovaric'IMaslovaric'I, et al. The effects of incubation media on the assessment of the shape of human erythrocytes by flow cytometry: a contribution to mathematical data interpretation to enable wider application of the method. Eur Biophys J. 2021;50(6):829-46. doi: 10.1007/s00249-021-01527-3; · DOI
  46. Paraiso LF, de Freitas MV, Gonçalves-E-Oliveira AFM, de Almeida Neto OP, Pereira EA, Mascarenhas Netto RC, et al. Influence of acute exercise on the osmotic stability of the human erythrocyte membrane. Int J Sports Med. 2014:35(13):1072-7. doi: 10.1055/s-0034-1371834; · DOI
  47. Kamada T, Tokuda S, Aozaki S, Otsuji S. Higher levels of erythrocyte membrane fluidity in sprinters and long-distance runners. J Appl Physiol (1985). 1993;74(1):354-8. doi: 10.1152/jappl.1993.74.1.354; · DOI
  48. Yamada T, Tohori M, Ashida T, Kajiwara N, Yoshimura H. Comparison of effects of vegetable protein diet and animal protein diet on the initiation of anemia during vigorous physical training (sports anemia) in dogs and rats. J Nutr Sci Vitaminol (Tokyo). 1987;33(2):129-49. doi: 10.3177/jnsv.33.129; · DOI
  49. Nemkov T, Skinner SC, Nader E, Stefanoni D, Robert M, Cendali F, et al. Acute cycling exercise induces changes in red blood cell deformability and membrane lipid remodeling. Int J Mol Sci. 2021;22(2):896. doi: 10.3390/ ijms22020896; · DOI
  50. Nader E, Guillot N, Lavorel L, Hancco I, Fort R, Stauffer E, et al. Eryptosis and hemorheological responses to maximal exercise in athletes: Comparison between running and cycling. Scand J Med Sci Sports. 2018;28(5):1532-40. doi: 10.1111/sms.13059; · DOI
  51. Kobayashi S, Hamazaki T, Sawazaki S, Nakamura H. Reduction in the ADP release from shear-stressed red blood cells by fish oil administration. Thromb Res.1992;65(3):353-64. doi: 10.1016/0049-3848(92)90166-8; · DOI
  52. Spodaryk K. Iron metabolism in boys involved in intensive physical training. Physiol Behav. 2002;75(1-2):201-6. doi: 10.1016/S0031-9384(01)00640-0; · DOI · Paper page
  53. Mariño MM, Grijota FJ, Bartolomé I, Siquier-Coll J, Román VT, Muñoz D. Influence of physical training on erythrocyte concentrations of iron, phosphorus and magnesium. J Int Soc Sports Nutr. 2020;17(1):1-7. doi: 10.1186/ s12970-020-0339-y; · DOI
  54. Nishiie-Yano R, Hirayama S, Tamura M, Kanemochi T, Ueno T, Hirayama A, et al. Hemolysis is responsible for elevation of serum iron concentration after regular exercises in judo athletes. Biol Trace Elem Res. 2020;197(1):63-9. doi: 10.1007/s12011-019-01981-3; · DOI
  55. Novosadova J. The changes in hematocrit, hemoglobin, plasma volume and proteins during and after diverse types of exercise. Eur J Appl Physiol Occup Physiol. 1977;36(3):223-30. doi: 10.1007/BF00421753; · DOI

Cited by

Metadata

Authors
Stefanović, R., Ristić, B., & Drvenica, I.
Venue
Srpski medicinski casopis Lekarske komore
Publisher
Centre for Evaluation in Education and Science (CEON/CEES)
Published
2024
Volume
5
Issue
2
Pages
215-227
ISSN
  • 2737-971X
  • 2737-9752
DOI
10.5937/smclk5-51250
Cited by
1
References
2
Language
en
Licence
creativecommons.org/licenses/BY/4.0 (unspecified)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.