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MicroRNA-21-5p mediates TGF-β-regulated fibrogenic activation of spinal fibroblasts and the formation of fibrotic scars after spinal cord injury

Wang, Wenzhao, Liu, Ronghan, Su, Yanlin, Li, Hongfei, Xie, Wei, Ning, Bin·2018·International Journal of Biological Sciences
DOI 10.7150/ijbs.24074PMC PMC5821039
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  • miR-21 is significantly upregulated after spinal cord injury, causes downregulation of targets FasL and PTEN, and its expression is directly related to secondary cell death following injury.

    “Several groups have identified miR-21 as significantly upregulated after spinal cord injury, causing downregulation of targets FasL and PTEN, and its expression is directly related to secondary cell death following injury16–18.”

    From CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system (2020) · cites this paper as [17]

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  32. [34]Jiang Y Wang C Li YY Wang XC An JD Wang YJ Mistletoe alkaloid fractions alleviates carbon tetrachloride-induced liver fibrosis through inhibition of hepatic stellate cell activation via TGF-beta/Smad interference Journal of ethnopharmacology 2014 158 Pt A 230 8 25456431
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Authors
Wang, W., Liu, R., Su, Y., Li, H., Xie, W., & Ning, B.
Venue
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Published
2018
Volume
14
Issue
2
Pages
178-188
ISSN
1449-2288
DOI
10.7150/ijbs.24074
PMC
PMC5821039
Cited by
80
References
2
Language
en

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